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- Publisher
- Springer Journals
- Copyright
- Copyright © 1996 by Springer-Verlag
- Subject
- Biomedicine; Molecular Medicine; Human Genetics; Internal Medicine
- ISSN
- 0946-2716
- eISSN
- 1432-1440
- DOI
- 10.1007/BF00204976
- Publisher site
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Abstract
Hepatocyte growth factor/scatter factor (HGF/SF) is a pleiotropic effector of cells expressing the Met tyrosine kinase receptor. While HGF/SF-Met signaling clearly plays a role in a variety of normal cellular processes, this signaling pathway has also been implicated in the generation and metastatic spread of tumors. This review discusses in detail several model systems that have been developed to investigate the role of HGF/SF-Met signaling in malignancy and describes additional data regarding the expression of these molecules in human tumors. Collectively the findings support a role for this receptor-ligand pair in human malignancy.
Journal
Journal of Molecular Medicine – Springer Journals
Published: Jul 15, 2004