Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/wiley/tumor-cells-utilize-multiple-pathways-to-down-modulate-apoptosis-yFMus1MWBs
References (56)
-
G. Teitelman, S. Alpert, D. Hanahan (1988)
Proliferation, senescence, and neoplastic progression of β cells in hyperplasic pancreatic isletsCell, 52
-
M. Sporn, A. Roberts (1990)
Peptide Growth Factors and Their Receptors I -
S. Efrat, S. Baekkeskov, D. Lane, D. Hanahan (1987)
Coordinate expression of the endogenous p53 gene in beta cells of transgenic mice expressing hybrid insulin‐SV40 T antigen genes.The EMBO Journal, 6
-
GE Arteel, RG Thurman, JM Yates, JA Raleigh (1995)
Evidence that hypoxia markers detect oxygen gradients in liver: pimonidazole and retrograde perfusion of rat liver.British Journal of Cancer, 72
-
B. Vogelstein, K. Kinzler (1993)
The multistep nature of cancer.Trends in genetics : TIG, 9 4
-
(1991)
The insulin-like growth factor I receptor: molecular biology, heterogeneity and regulation -
David Halg, Chris Graham (1991)
Genomic imprinting and the strange case of the insulin-like growth factor II receptorCell, 64
-
G. Christofori, P. Naik, D. Hanahan (1994)
A second signal supplied by insulin-like growth factor II in oncogene-induced tumorigenesisNature, 369
-
Jian Dong, M. Naito, T. Tsuruo (1997)
c-Myc plays a role in cellular susceptibility to death receptor-mediated and chemotherapy-induced apoptosis in human monocytic leukemia U937 cellsOncogene, 15
-
A. Filson, A. Louvi, A. Efstratiadis, E. Robertson (1993)
Rescue of the T-associated maternal effect in mice carrying null mutations in Igf-2 and Igf2r, two reciprocally imprinted genes.Development, 118 3
-
C. Thompson (1995)
Apoptosis in the pathogenesis and treatment of diseaseScience, 267
-
A. Bakhshi, Jane Jensen, P. Goldman, John Wright, O. McBride, Alan Epstein, S. Korsmeyer (1985)
Cloning the chromosomal breakpoint of t(14;18) human lymphomas: clustering around Jh on chromosome 14 and near a transcriptional unit on 18Cell, 41
-
S. Datta, H. Dudek, Xu Tao, S. Masters, H. Fu, Y. Gotoh, M. Greenberg (1997)
Akt Phosphorylation of BAD Couples Survival Signals to the Cell-Intrinsic Death MachineryCell, 91
-
Sareh Parangi, William Dietrich, Gerhard Christofori, Eric Lander, Douglas Hanahan (1995)
Tumor suppressor loci on mouse chromosomes 9 and 16 are lost at distinct stages of tumorigenesis in a transgenic model of islet cell carcinoma.Cancer research, 55 24
-
Reiner Janicke, Fiona Lee, A. Porter (1994)
Nuclear c-Myc plays an important role in the cytotoxicity of tumor necrosis factor alpha in tumor cellsMolecular and Cellular Biology, 14
-
D. Hanahan (1985)
Heritable formation of pancreatic beta-cell tumours in transgenic mice expressing recombinant insulin/simian virus 40 oncogenes.Nature, 315 6015
-
Gavin Thurston, John McLean, Michael Rizen, P. Baluk, A. Haskell, Thomas Murphy, Douglas Hanahan, Donald McDonald (1998)
Cationic liposomes target angiogenic endothelial cells in tumors and chronic inflammation in mice.The Journal of clinical investigation, 101 7
-
(1995)
Tumor angiogenesis. In The Molecular Basis of Cancer -
N. Rampino, H. Yamamoto, Y. Ionov, Y. Li, H. Sawai, John Reed, M. Perucho (1997)
Somatic Frameshift Mutations in the BAX Gene in Colon Cancers of the Microsatellite Mutator PhenotypeScience, 275
-
M. Resnicoff, R. Baserga (1998)
The Role of the Insulin‐like Growth Factor I Receptor in Transformation and ApoptosisAnnals of the New York Academy of Sciences, 842
-
P. Naik, J. Karrim, D. Hanahan, Sharleen Zhou, A. Kuo, B. Cairns, G. Crabtree, R. Levinson, K. Yamamoto, R. Kornberg, C. Wolkow, R. Deboy, N. Craig, John Mueller (1996)
The rise and fall of apoptosis during multistage tumorigenesis: down-modulation contributes to tumor progression from angiogenic progenitors.Genes & development, 10 17
-
H. Symonds, L. Krall, L. Remington, M. Sáenz-Robles, S. Lowe, T. Jacks, T. Dyke (1994)
p53-Dependent apoptosis suppresses tumor growth and progression in vivoCell, 78
-
D. Hanahan, J. Folkman (1996)
Patterns and Emerging Mechanisms of the Angiogenic Switch during TumorigenesisCell, 86
-
E. White (1996)
Life, death, and the pursuit of apoptosis.Genes & development, 10 1
-
Janice Brown, A. Giaccia (1998)
The unique physiology of solid tumors: opportunities (and problems) for cancer therapy.Cancer research, 58 7
-
John Reed (1997)
Double identity for proteins of the Bcl-2 familyNature, 387
-
M. Cleary, J. Sklar (1985)
Nucleotide sequence of a t(14;18) chromosomal breakpoint in follicular lymphoma and demonstration of a breakpoint-cluster region near a transcriptionally active locus on chromosome 18.Proceedings of the National Academy of Sciences of the United States of America, 82 21
-
J. Ludlow (1993)
Interactions between SV40 large‐tumor antigen and the growth suppressor proteins pRB and p53The FASEB Journal, 7
-
S. Alpert, D. Hanahan, G. Teitelman (1988)
Hybrid insulin genes reveal a developmental lineage for pancreatic endocrine cells and imply a relationship with neuronsCell, 53
-
L. Holmgren, M. O’Reilly, J. Folkman (1995)
Dormancy of micrometastases: Balanced proliferation and apoptosis in the presence of angiogenesis suppressionNature Medicine, 1
-
A. Levine (1997)
p53, the Cellular Gatekeeper for Growth and DivisionCell, 88
-
(1996)
The regulation and role of cell survival and cell death in multistage tumorigenesis -
S. Parangi, M. O’Reilly, G. Christofori, G. Christofori, L. Holmgren, L. Holmgren, J. Grosfeld, J. Folkman, D. Hanahan (1996)
Antiangiogenic therapy of transgenic mice impairs de novo tumor growth.Proceedings of the National Academy of Sciences of the United States of America, 93 5
-
D. Finegood, L. Scaglia, S. Bonner-Weir (1995)
Dynamics of β-cell Mass in the Growing Rat Pancreas: Estimation With a Simple Mathematical ModelDiabetes, 44
-
A. Kauffmann-Zeh, P. Rodriguez-Viciana, E. Ulrich, C. Gilbert, P. Coffer, J. Downward, G. Evan (1997)
Suppression of c-Myc-induced apoptosis by Ras signalling through PI(3)K and PKBNature, 385
-
M. Krajewska, S. Moss, S. Krajewski, K. Song, P. Holt, John Reed (1996)
Elevated expression of Bcl-X and reduced Bak in primary colorectal adenocarcinomas.Cancer research, 56 10
-
W. Dietrich, E. Radany, J. Smith, J. Bishop, D. Hanahan, E. Lander (1994)
Genome-wide search for loss of heterozygosity in transgenic mouse tumors reveals candidate tumor suppressor genes on chromosomes 9 and 16.Proceedings of the National Academy of Sciences of the United States of America, 91 20
-
M. Krajewska, S. Krajewski, J. Epstein, A. Shabaik, J. Sauvageot, K. Song, S. Kitada, John Reed (1996)
Immunohistochemical analysis of bcl-2, bax, bcl-X, and mcl-1 expression in prostate cancers.The American journal of pathology, 148 5
-
A. Perl, P. Wilgenbus, U. Dahl, H. Semb, G. Christofori (1998)
A causal role for E-cadherin in the transition from adenoma to carcinomaNature, 392
-
Miyashita Toshiyuki, John Reed (1995)
Tumor suppressor p53 is a direct transcriptional activator of the human bax geneCell, 80
-
P. Naik, G. Christofori, D. Hanahan (1994)
Insulin-like growth factor II is focally up-regulated and functionally involved as a second signal for oncogene-induced tumorigenesis.Cold Spring Harbor symposia on quantitative biology, 59
-
G. Bergers (1999)
Effects of angiogenesis on multistage carcinogenesis in mice, 284
-
Sandra, E. Dunn, Michael, Ehrlich, Nicholas, J. Sharp, K. Reiss, Gregory, Solomon, Rebecca, Hawkins, Renato, Baserga, J. Barrett (1998)
A dominant negative mutant of the insulin-like growth factor-I receptor inhibits the adhesion, invasion, and metastasis of breast cancer.Cancer research, 58 15
-
J. Klefstrom, E. Arighi, T. Littlewood, M. Jäättelä, E. Saksela, G. Evan, K. Alitalo (1997)
Induction of TNF‐sensitive cellular phenotype by c‐Myc involves p53 and impaired NF‐κB activationThe EMBO Journal, 16
-
G. Lamm, Gerhard Christofori (1998)
Impairment of survival factor function potentiates chemotherapy-induced apoptosis in tumor cells.Cancer research, 58 4
-
R. Jain (1988)
Determinants of tumor blood flow: a review.Cancer research, 48 10
-
(1991)
Insulin-like growth factor II: Gene structure and expression into messenger RNA and protein -
P. Hainaut, T. Hernandez, A. Robinson, P. Rodriguez-Tomé, T. Flores, M. Hollstein, C. Harris, R. Montesano (1998)
IARC Database of p53 gene mutations in human tumors and cell lines: updated compilation, revised formats and new visualisation toolsNucleic acids research, 26 1
-
D. Hanahan (1998)
A flanking attack on cancerNature Medicine, 4
-
R. Alarcon, B. Rupnow, T. Graeber, S. Knox, A. Giaccia (1996)
Modulation of c-Myc activity and apoptosis in vivo.Cancer research, 56 19
-
M. Cardone, N. Roy, H. Stennicke, G. Salvesen, T. Franke, E. Stanbridge, S. Frisch, John Reed (1998)
Regulation of cell death protease caspase-9 by phosphorylation.Science, 282 5392
-
Charlotte Kim, Mi-Hau Tsai, Cynthia Osmanian, T. Graeber, Jong Lee, R. Giffard, J. DiPaolo, D. Peehl, A. Giaccia (1997)
Selection of human cervical epithelial cells that possess reduced apoptotic potential to low-oxygen conditions.Cancer research, 57 19
-
G. Bergers, K. Javaherian, K. Lo, J. Folkman, D. Hanahan (1999)
Effects of angiogenesis inhibitors on multistage carcinogenesis in mice.Science, 284 5415
-
T. Graeber, Cynthia Osmanian, T. Jacks, D. Housman, C. Koch, S. Lowe, A. Giaccia (1996)
Hypoxia-mediated selection of cells with diminished apoptotic potential in solid tumoursNature, 379
-
L. Peso, M. González‐García, C. Page, R. Herrera, G. Núñez (1997)
Interleukin-3-induced phosphorylation of BAD through the protein kinase Akt.Science, 278 5338
-
J. Folkman, K. Watson, D. Ingber, D. Hanahan (1989)
Induction of angiogenesis during the transition from hyperplasia to neoplasiaNature, 339
- Publisher
- Wiley
- Copyright
- Copyright © $year Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 0077-8923
- eISSN
- 1749-6632
- DOI
- 10.1111/j.1749-6632.1999.tb07929.x
- Publisher site
- See Article on Publisher Site
Abstract
Apoptosis, the process of programmed cell death, plays a critical role in many normal and pathological (disease) processes. 1 In normal tissues, apoptosis functions in the homeostatic maintenance of proper tissue and organ size by eliminating aged cells to offset the birth of new cells that arise by mitosis. In disease, apoptosis can affect the pathological process is two disparate ways. There are diseases that have too much apoptosis such as autoimmune diabetes and Alzheimer's, or those that have too little apoptosis, such as cancer. This review will focus on the latter and, more specifically, detail and summarize some important lessons learned about apoptosis and cancer from studying a transgenic mouse model of islet cell carcinoma, RIP‐Tag, as outlined below.
Journal
Annals of the New York Academy of Sciences – Wiley
Published: Dec 1, 1999