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Expression of stem cell factor in basal cell carcinoma

Expression of stem cell factor in basal cell carcinoma SummaryStem cell factor (SCF) distribution in basal cell carcinomas (BCCs) was examined by immunohisto‐chemistry. Eighteen BCCs (11 nodular, three superficial, two cystic, one adenoid and one morphoeic type) showed positive expression of SCF in the tumour islands. The centre of the tumour island was strongly positive in nodular, superficial and morphoeic types. In cystic BCCs. SCF‐positive tumour cells were also located in the peripheral lesion around the cystic space. SCF was also detected on fibroblast‐like cells and mast cells in the stroma. SCF was positively stained within the upper keratinocytes in the overlying epidermis, more strongly as compared with normal skin. The mast cell number (mean ± SD)) was significantly increased in the peritumoral stroma (85.7 ± 28. 3/mm2) compared with normal skin (32.1 ±4.2/mm2) (P<0.005). SCF was also positive in the tumour nests of four cases of trichoepithelioma, in which fibrosis of the surrounding stroma was found histologically. This study demonstrates that abundant SCF produced by the tumour cells may account for the increased number of stromal mast cells, which induce fibroplasia of the surrounding stroma. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Dermatology Oxford University Press

Expression of stem cell factor in basal cell carcinoma

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References (64)

Publisher
Oxford University Press
Copyright
© 1997 British Association of Dermatologists
ISSN
0007-0963
eISSN
1365-2133
DOI
10.1046/j.1365-2133.1997.19402055.x
Publisher site
See Article on Publisher Site

Abstract

SummaryStem cell factor (SCF) distribution in basal cell carcinomas (BCCs) was examined by immunohisto‐chemistry. Eighteen BCCs (11 nodular, three superficial, two cystic, one adenoid and one morphoeic type) showed positive expression of SCF in the tumour islands. The centre of the tumour island was strongly positive in nodular, superficial and morphoeic types. In cystic BCCs. SCF‐positive tumour cells were also located in the peripheral lesion around the cystic space. SCF was also detected on fibroblast‐like cells and mast cells in the stroma. SCF was positively stained within the upper keratinocytes in the overlying epidermis, more strongly as compared with normal skin. The mast cell number (mean ± SD)) was significantly increased in the peritumoral stroma (85.7 ± 28. 3/mm2) compared with normal skin (32.1 ±4.2/mm2) (P<0.005). SCF was also positive in the tumour nests of four cases of trichoepithelioma, in which fibrosis of the surrounding stroma was found histologically. This study demonstrates that abundant SCF produced by the tumour cells may account for the increased number of stromal mast cells, which induce fibroplasia of the surrounding stroma.

Journal

British Journal of Dermatology – Oxford University Press

Published: Nov 1, 1997

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