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Risk of Non‐Hodgkin's Lymphoma in Primary Sjögren's Syndrome: A Population‐Based Study

Risk of Non‐Hodgkin's Lymphoma in Primary Sjögren's Syndrome: A Population‐Based Study Objective Primary Sjögren's syndrome (SS) is associated with an increased risk of non‐Hodgkin's lymphoma (NHL), but the reported prevalence and risk vary considerably. The objective of this study was to determine the risk of NHL in a well‐defined population‐based primary SS cohort in Norway. Methods The authors examined all patients fulfilling the American–European Consensus Group criteria for primary SS from 2 Norwegian counties and compared the data to the Cancer Registry of Norway to identify the primary SS patients who had lymphoma. In addition, lymphoma patient files from the same period were reviewed for undiagnosed primary SS to ensure the quality of registry data. Results As of July 1, 2009, 443 living subjects with primary SS were identified in an area with 896,840 inhabitants, which is 18.6% of the total population of Norway. Seven cases of NHL (1.6%) were found during a total followup of 3,813 person‐years, resulting in a standardized incidence ratio of 9.0 (95% confidence interval 7.1–26.3) for NHL in primary SS patients. Conclusion The risk of NHL in patients with primary SS in Norway is increased 9 times compared with the general population. This is in accordance with recent studies, and the quality and completeness of the registries and strict use of diagnostic criteria support the validity of the results. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Arthritis Care and Research Wiley

Risk of Non‐Hodgkin's Lymphoma in Primary Sjögren's Syndrome: A Population‐Based Study

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References (11)

Publisher
Wiley
Copyright
Copyright © 2013 by the American College of Rheumatology
ISSN
2151-464X
eISSN
2151-4658
DOI
10.1002/acr.21887
pmid
23139233
Publisher site
See Article on Publisher Site

Abstract

Objective Primary Sjögren's syndrome (SS) is associated with an increased risk of non‐Hodgkin's lymphoma (NHL), but the reported prevalence and risk vary considerably. The objective of this study was to determine the risk of NHL in a well‐defined population‐based primary SS cohort in Norway. Methods The authors examined all patients fulfilling the American–European Consensus Group criteria for primary SS from 2 Norwegian counties and compared the data to the Cancer Registry of Norway to identify the primary SS patients who had lymphoma. In addition, lymphoma patient files from the same period were reviewed for undiagnosed primary SS to ensure the quality of registry data. Results As of July 1, 2009, 443 living subjects with primary SS were identified in an area with 896,840 inhabitants, which is 18.6% of the total population of Norway. Seven cases of NHL (1.6%) were found during a total followup of 3,813 person‐years, resulting in a standardized incidence ratio of 9.0 (95% confidence interval 7.1–26.3) for NHL in primary SS patients. Conclusion The risk of NHL in patients with primary SS in Norway is increased 9 times compared with the general population. This is in accordance with recent studies, and the quality and completeness of the registries and strict use of diagnostic criteria support the validity of the results.

Journal

Arthritis Care and Research – Wiley

Published: May 1, 2013

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