Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

CARDIOVASCULAR ACTIONS OF MELANOCYTE-STIMULATING HORMONE IN THE DOG

CARDIOVASCULAR ACTIONS OF MELANOCYTE-STIMULATING HORMONE IN THE DOG Administration of melanocyte-stimulating hormone (MSH) has been shown to produce an increment in heart rate in the heart—lung preparation of the dog and in intact dogs pretreated with reserpine so as to deplete catecholamines (Krayer, Astwood, Wand & Alper, 1961). It also has been shown to increase the frequency of pulsation of isolated chick heart muscle cells (Wollenberger & Halle, 1964), and to increase the heart rate in human beings (Kastin, Kullander, Borglin, Dahlberg, Dyster-Aas, Krakau, Ingvar, Miller, Bowers & Schally, 1968). In view of these findings, the present study was undertaken to ascertain the effects of MSH on ventricular contractility as well as heart rate in the intact dog and to observe the effect of beta-receptor blockade on this MSH activity.Ten mongrel dogs (10–15 kg) of both sexes were anaesthetized with sodium pentobarbitone (25 mg/kg, i.v.). Ventricular contractile force (VCF), heart rate (HR), arterial blood pressure (BP) and http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Endocrinology Bioscientifica

CARDIOVASCULAR ACTIONS OF MELANOCYTE-STIMULATING HORMONE IN THE DOG

Download PDF
2 pages

Loading next page...
 
/lp/bioscientifica/cardiovascular-actions-of-melanocyte-stimulating-hormone-in-the-dog-xRJ7lMNrVZ

References (0)

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Bioscientifica
Copyright
Copyright © 1973 The Authors. All Rights Reserved.
ISSN
0022-0795
eISSN
1479-6805
DOI
10.1677/joe.0.0560613
Publisher site
See Article on Publisher Site

Abstract

Administration of melanocyte-stimulating hormone (MSH) has been shown to produce an increment in heart rate in the heart—lung preparation of the dog and in intact dogs pretreated with reserpine so as to deplete catecholamines (Krayer, Astwood, Wand & Alper, 1961). It also has been shown to increase the frequency of pulsation of isolated chick heart muscle cells (Wollenberger & Halle, 1964), and to increase the heart rate in human beings (Kastin, Kullander, Borglin, Dahlberg, Dyster-Aas, Krakau, Ingvar, Miller, Bowers & Schally, 1968). In view of these findings, the present study was undertaken to ascertain the effects of MSH on ventricular contractility as well as heart rate in the intact dog and to observe the effect of beta-receptor blockade on this MSH activity.Ten mongrel dogs (10–15 kg) of both sexes were anaesthetized with sodium pentobarbitone (25 mg/kg, i.v.). Ventricular contractile force (VCF), heart rate (HR), arterial blood pressure (BP) and

Journal

Journal of Endocrinology – Bioscientifica

Published: Mar 1, 1973

There are no references for this article.