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Acute hyperglycemia and the innate immune system: Clinical, cellular, and molecular aspects

Acute hyperglycemia and the innate immune system: Clinical, cellular, and molecular aspects Review Article Acute hyperglycemia and the innate immune system: Clinical, cellular, and molecular aspects Matthias Turina, MD; Donald E. Fry, MD; Hiram C. Polk Jr, MD Objective: To extract from the biomedical literature the re- cluded reduced neutrophil activity (e.g., chemotaxis, formation of ported effects of acute hyperglycemia on the major components reactive oxygen species, phagocytosis of bacteria), despite ac- of the innate immune system and to describe the clinical benefits celerated diapedesis of leukocytes into peripheral tissue, as well of strict blood glucose control in certain patients. as specific alterations of cytokine patterns with increased con- Data Source and Selection: A Medline/PubMed search (1966 to centrations of the early proinflammatory cytokines tumor necrosis July 2004) with manual cross-referencing was conducted, includ- factor- and interleukin-6. Furthermore, a reduction of endothe- ing all relevant articles investigating the effects of acutely ele- lial nitric oxide formation takes place, thus decreasing microvas- vated glucose levels on innate immunity. All publication types, cular reactivity to dilating agents such as bradykinin, and com- languages, or subsets were searched. plement function (e.g., opsonization, chemotaxis) is impaired, Data Extraction and Synthesis: Original and selected review despite elevations of certain complement factors. articles, short communications, letters to http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Critical Care Medicine Wolters Kluwer Health

Acute hyperglycemia and the innate immune system: Clinical, cellular, and molecular aspects

Polk, Hiram C.
Critical Care Medicine , Volume 33 (7) – Jul 1, 2005
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ISSN
0090-3493
eISSN
1530-0293
DOI
10.1097/01.CCM.0000170106.61978.D8
Publisher site
See Article on Publisher Site

Abstract

Review Article Acute hyperglycemia and the innate immune system: Clinical, cellular, and molecular aspects Matthias Turina, MD; Donald E. Fry, MD; Hiram C. Polk Jr, MD Objective: To extract from the biomedical literature the re- cluded reduced neutrophil activity (e.g., chemotaxis, formation of ported effects of acute hyperglycemia on the major components reactive oxygen species, phagocytosis of bacteria), despite ac- of the innate immune system and to describe the clinical benefits celerated diapedesis of leukocytes into peripheral tissue, as well of strict blood glucose control in certain patients. as specific alterations of cytokine patterns with increased con- Data Source and Selection: A Medline/PubMed search (1966 to centrations of the early proinflammatory cytokines tumor necrosis July 2004) with manual cross-referencing was conducted, includ- factor- and interleukin-6. Furthermore, a reduction of endothe- ing all relevant articles investigating the effects of acutely ele- lial nitric oxide formation takes place, thus decreasing microvas- vated glucose levels on innate immunity. All publication types, cular reactivity to dilating agents such as bradykinin, and com- languages, or subsets were searched. plement function (e.g., opsonization, chemotaxis) is impaired, Data Extraction and Synthesis: Original and selected review despite elevations of certain complement factors. articles, short communications, letters to

Journal

Critical Care Medicine – Wolters Kluwer Health

Published: Jul 1, 2005

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