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Lactoferrin Inhibits Enterovirus 71 Infection of Human Embryonal Rhabdomyosarcoma Cells In Vitro

Lactoferrin Inhibits Enterovirus 71 Infection of Human Embryonal Rhabdomyosarcoma Cells In Vitro Enterovirus 71 (EV71), the newest member of Enterovirudae is notable for its etiological role in epidemics of severe neurological diseases in children. It appears to be emerging as an important virulent neurotropic enterovirus in the upcoming era of poliomyelitis eradication, whereas no effective vaccine or antiviral agents are available at this moment. Human and bovine lactoferrins, iron-binding proteins belonging to the nonimmune defense system, were assayed in vitro to assess their inhibiting capacity on the cytopathic effect of EV71 on human embryonal rhabdomyosarcoma (RD) cells. Both bovine and human lactoferrins were found to be potent inhibitors of EV71 infection (mean IC50, 10.5–24.5 μg/mL and 103.3–185.0 μg/mL, respectively). Lactoferrin probably exerts its effect at the level of viral adsorption, since the ongoing infection could not be further inhibited after the EV71 penetrated RD cells http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Infectious Diseases Oxford University Press

Lactoferrin Inhibits Enterovirus 71 Infection of Human Embryonal Rhabdomyosarcoma Cells In Vitro

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References (15)

Publisher
Oxford University Press
Copyright
© Published by Oxford University Press.
Subject
Concise Communications
ISSN
0022-1899
eISSN
1537-6613
DOI
10.1086/343809
pmid
12355368
Publisher site
See Article on Publisher Site

Abstract

Enterovirus 71 (EV71), the newest member of Enterovirudae is notable for its etiological role in epidemics of severe neurological diseases in children. It appears to be emerging as an important virulent neurotropic enterovirus in the upcoming era of poliomyelitis eradication, whereas no effective vaccine or antiviral agents are available at this moment. Human and bovine lactoferrins, iron-binding proteins belonging to the nonimmune defense system, were assayed in vitro to assess their inhibiting capacity on the cytopathic effect of EV71 on human embryonal rhabdomyosarcoma (RD) cells. Both bovine and human lactoferrins were found to be potent inhibitors of EV71 infection (mean IC50, 10.5–24.5 μg/mL and 103.3–185.0 μg/mL, respectively). Lactoferrin probably exerts its effect at the level of viral adsorption, since the ongoing infection could not be further inhibited after the EV71 penetrated RD cells

Journal

Journal of Infectious Diseases – Oxford University Press

Published: Oct 15, 2002

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