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- Publisher
- Springer Journals
- Copyright
- Copyright © 1973 by International Pediatrics Research Foundation, Inc.
- Subject
- Medicine & Public Health; Medicine/Public Health, general; Pediatrics; Pediatric Surgery
- ISSN
- 0031-3998
- eISSN
- 1530-0447
- DOI
- 10.1203/00006450-197311000-00009
- Publisher site
- See Article on Publisher Site
Abstract
Extract: Chloramphenicol (CHL) treatment in rats begun 0–2 hr after birth inhibited the increase in oxygen uptake, particularly the metabolic response to cold, during the first neonatal days. In rats treated for 5 days with CHL, a few hours after elimination of the drug from the body the tissue levels of ADP and Pi were significantly higher and the levels of ATP significantly lower than in controls. Furthermore, the presence of more than 0.2 mM free CHL in serum and liver caused a decrease in oxygen consumption and ATP levels and an increase in Pi levels. These changes, progressive with increasing CHL concentrations, appeared to be due to direct interference of CHL with mitochondrial electron transport.
Journal
Pediatric Research – Springer Journals
Published: Nov 1, 1973