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- Publisher
- Oxford University Press
- Copyright
- © 2008 Institute of Biochemistry and Cell Biology, SIBS, CAS
- ISSN
- 1672-9145
- eISSN
- 1745-7270
- DOI
- 10.1111/j.1745-7270.2008.00434.x
- Publisher site
- See Article on Publisher Site
Abstract
AbstractAs a master switch for cell proliferation and differentiation, Myc exerts its biological functions mainly through transcrip-tional regulation of its target genes, which are involved in cells' interaction and communication with their external environment. The N-Myc downstream-regulated gene (NDRG) family is composed of NDRG1, NDRG2, NDRG3 and NDRG4, which are important in cell proliferation and differentiation. This review summarizes the recent studies on the structure, tissue distribution and functions of NDRG2 that try to show its significance in studying cancer and its therapeutic potential.
Journal
Acta Biochimica et Biophysica Sinica – Oxford University Press
Published: Jul 1, 2008
Keywords: N-Myc downstream-regulated gene tumor suppressor cell stress