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- Publisher
- Humana Press
- Copyright
- © Humana Press 2008
- ISBN
- 978-1-58829-897-3
- Pages
- 69–82
- DOI
- 10.1007/978-1-59745-234-2_5
- Publisher site
- See Chapter on Publisher Site
Abstract
[Prion-propagating cell lines are an efficient and useful means for studying the cellular and molecular mechanisms implicated in prion disease. Use of cell-based models has lead to the finding that prion protein (PrPC) and PrPSc are released from cells in association with exosomes. Furthermore, exosomes have been shown to act as vehicles for infectivity, transferring PrPSc between cell lines and providing a mechanism for prion spread between tissues. As a role for exo-somes in prion disease is emerging, this chapter outlines a method for the generation of prion-infected cell lines and the isolation and characterization of PrPC- and PrPSc-containing exosomes.]
Published: Jan 1, 2008
Keywords: Cell culture media; exosomes; GT1–7; infection; passaging; prion