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SPECIFIC ANOSMIAS TO 5α-ANDROST-16-EN-3-ONE AND ω-PENTADECALACTONE: THE URINOUS AND MUSKY PRIMARY ODORS

SPECIFIC ANOSMIAS TO 5α-ANDROST-16-EN-3-ONE AND ω-PENTADECALACTONE: THE URINOUS AND MUSKY PRIMARY... Abstract About 46% of human subjects are specifically anosmic to the odor of 5α-androst-16-en-3- one, and about 9% are specifically anosmic to the odor of ω-pentadecalactone. Odor threshold measurements on 33 representative steroids, synthetic musks and related compounds were made with panels of normal observers and each of these varieties of specific anosmics. The androstenone anosmia was most pronounced with steroid ketones in the androstane series and some isosteric analogs. It is suggested that this specific anosmia corresponds with the absence of a recently-suspected olfactory primary, the ‘urinous’ odor. The pentadecalactone anosmia was associated with a number of diverse but approximately isosteric synthetic musks. This specific anosmia delineates more clearly the boundaries of the ‘musky’ odor, whose probably primacy has long been recognized. Threshold measurements were made on mixtures of androst-16-en-3-one and pentadecalactone. The results depart little from the ‘rule of additivity’ for odor ratios up to 100:1, and suggest a quantitative interpretation for the anosmic defects measured with single compounds. This content is only available as a PDF. Author notes * Permanent address: Istituto di Industrie Agrarie della Università degli Studi, Pisa, Italy. © 1977 by D. Reidel Publishing Company, Dordrecht-Holland http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Chemical Senses Oxford University Press

SPECIFIC ANOSMIAS TO 5α-ANDROST-16-EN-3-ONE AND ω-PENTADECALACTONE: THE URINOUS AND MUSKY PRIMARY ODORS

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Publisher
Oxford University Press
Copyright
© 1977 by D. Reidel Publishing Company, Dordrecht-Holland
ISSN
0379-864X
eISSN
1464-3553
DOI
10.1093/chemse/2.4.401
Publisher site
See Article on Publisher Site

Abstract

Abstract About 46% of human subjects are specifically anosmic to the odor of 5α-androst-16-en-3- one, and about 9% are specifically anosmic to the odor of ω-pentadecalactone. Odor threshold measurements on 33 representative steroids, synthetic musks and related compounds were made with panels of normal observers and each of these varieties of specific anosmics. The androstenone anosmia was most pronounced with steroid ketones in the androstane series and some isosteric analogs. It is suggested that this specific anosmia corresponds with the absence of a recently-suspected olfactory primary, the ‘urinous’ odor. The pentadecalactone anosmia was associated with a number of diverse but approximately isosteric synthetic musks. This specific anosmia delineates more clearly the boundaries of the ‘musky’ odor, whose probably primacy has long been recognized. Threshold measurements were made on mixtures of androst-16-en-3-one and pentadecalactone. The results depart little from the ‘rule of additivity’ for odor ratios up to 100:1, and suggest a quantitative interpretation for the anosmic defects measured with single compounds. This content is only available as a PDF. Author notes * Permanent address: Istituto di Industrie Agrarie della Università degli Studi, Pisa, Italy. © 1977 by D. Reidel Publishing Company, Dordrecht-Holland

Journal

Chemical Senses – Oxford University Press

Published: Dec 1, 1977

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