Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Selective deficit in no‐go performance induced by blockade of prefrontal cortical &agr; 2

Selective deficit in no‐go performance induced by blockade of prefrontal cortical &agr; 2 COGNITIVE NEUROSCIENCE NEUROREPORT Selective de¢cit in no-go performance induced by blockade of prefrontal cortical a -adrenoceptors in monkeys CA Chao-Lin Ma, Xue-Lian Qi, Ji-Yun Peng and Bao-Ming Li Laboratory of Higher brain functions, Institute of Neurobiology, Fudan University, 220 Han-Dan Road, Shanghai 200433,China CA Corresponding Author: [email protected] Received15 February 2003; accepted 25 February 2003 DOI:10.1097/01.wnr.0000070831.57864.7b Two monkeys (Macacamulatta) were trained to make a go response showed an inability to inhibit the touching response to the no-go (go to touch a computer screen) when a red signal (go signal) was signal, indicating that there was a de¢cit in the inhibitory ability of presented or a no-go response (inhibit the screen-touching action) the animals. Similar infusion of saline into the same cortical area when a green signal (no-go signal) was given.The a -adrenergic an- was without e¡ect. The present study provides behavioral tagonist yohimbine was infused locally, bilaterally and continuously pharmacological evidence thata -adrenoceptors in the PFC arein- for 8 days into the prefrontal cortex (PFC) by using mini-osmotic volved in the neural mechanisms underlying response inhibition. pump.The no-go but not go performance was selectively impaired NeuroReport14:1013^1016 2003 Lippincott Williams & Wilkins. during the 8-day administration of yohimbine: the monkeys Key http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Neuroreport Wolters Kluwer Health

Selective deficit in no‐go performance induced by blockade of prefrontal cortical &agr; 2

Li, Bao‐ Ming
Neuroreport , Volume 14 (7) – May 1, 2003
Download PDF
4 pages

Loading next page...
 
/lp/wolters-kluwer-health/selective-deficit-in-no-hyphen-go-performance-induced-by-blockade-of-w5rMGuQG9b

References (16)

Copyright
© 2003 Lippincott Williams & Wilkins.
ISSN
0959-4965
eISSN
1473-558X
DOI
10.1097/01.wnr.0000070831.57864.7b
pmid
12802193
Publisher site
See Article on Publisher Site

Abstract

COGNITIVE NEUROSCIENCE NEUROREPORT Selective de¢cit in no-go performance induced by blockade of prefrontal cortical a -adrenoceptors in monkeys CA Chao-Lin Ma, Xue-Lian Qi, Ji-Yun Peng and Bao-Ming Li Laboratory of Higher brain functions, Institute of Neurobiology, Fudan University, 220 Han-Dan Road, Shanghai 200433,China CA Corresponding Author: [email protected] Received15 February 2003; accepted 25 February 2003 DOI:10.1097/01.wnr.0000070831.57864.7b Two monkeys (Macacamulatta) were trained to make a go response showed an inability to inhibit the touching response to the no-go (go to touch a computer screen) when a red signal (go signal) was signal, indicating that there was a de¢cit in the inhibitory ability of presented or a no-go response (inhibit the screen-touching action) the animals. Similar infusion of saline into the same cortical area when a green signal (no-go signal) was given.The a -adrenergic an- was without e¡ect. The present study provides behavioral tagonist yohimbine was infused locally, bilaterally and continuously pharmacological evidence thata -adrenoceptors in the PFC arein- for 8 days into the prefrontal cortex (PFC) by using mini-osmotic volved in the neural mechanisms underlying response inhibition. pump.The no-go but not go performance was selectively impaired NeuroReport14:1013^1016 2003 Lippincott Williams & Wilkins. during the 8-day administration of yohimbine: the monkeys Key

Journal

Neuroreport – Wolters Kluwer Health

Published: May 1, 2003

There are no references for this article.