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First‐trimester antihistamine exposure and risk of spontaneous abortion or preterm birth

First‐trimester antihistamine exposure and risk of spontaneous abortion or preterm birth ABSTRACT Purpose We tested whether antihistamine exposure during early pregnancy is associated with spontaneous abortion (SAB) or preterm birth (PTB). Methods Women were enrolled in Right from the Start (2004–2010), a prospective pregnancy cohort. Data about first‐trimester antihistamine use were obtained from screening and first‐trimester interviews. Self‐reported outcomes included SAB and PTB and were verified by medical records. Cox proportional hazards models were used to test for an association between antihistamine use and each outcome, both performed adjusting for confounders. Results Among the 2685 pregnancies analyzed, 14% (n = 377) reported use of antihistamines. Among antihistamine users, 12% (n = 44) experienced SABs, and 6% (n = 21) had PTBs. Antihistamine exposure was not associated with SAB (adjusted hazard ratio (aHR) = 0.88, 95% confidence interval (CI) 0.64, 1.21) or PTB, which was modified by maternal race (aHR = 1.03, 95%CI 0.61, 1.72 among White women and aHR = 0.43, 95%CI 0.14, 1.34 among Black women). Conclusions Despite the biologic plausibility that antihistamine use may influence pregnancy outcomes, we did not detect evidence of an association with SAB or PTB. These data demonstrate the utility of large prospective cohorts for evaluating drug safety in pregnancy when concerns are raised from animal models. Copyright © 2014 John Wiley & Sons, Ltd. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Pharmacoepidemiology and Drug Safety Wiley

First‐trimester antihistamine exposure and risk of spontaneous abortion or preterm birth

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References (20)

Publisher
Wiley
Copyright
Copyright © 2014 John Wiley & Sons, Ltd.
ISSN
1053-8569
eISSN
1099-1557
DOI
10.1002/pds.3637
pmid
24789281
Publisher site
See Article on Publisher Site

Abstract

ABSTRACT Purpose We tested whether antihistamine exposure during early pregnancy is associated with spontaneous abortion (SAB) or preterm birth (PTB). Methods Women were enrolled in Right from the Start (2004–2010), a prospective pregnancy cohort. Data about first‐trimester antihistamine use were obtained from screening and first‐trimester interviews. Self‐reported outcomes included SAB and PTB and were verified by medical records. Cox proportional hazards models were used to test for an association between antihistamine use and each outcome, both performed adjusting for confounders. Results Among the 2685 pregnancies analyzed, 14% (n = 377) reported use of antihistamines. Among antihistamine users, 12% (n = 44) experienced SABs, and 6% (n = 21) had PTBs. Antihistamine exposure was not associated with SAB (adjusted hazard ratio (aHR) = 0.88, 95% confidence interval (CI) 0.64, 1.21) or PTB, which was modified by maternal race (aHR = 1.03, 95%CI 0.61, 1.72 among White women and aHR = 0.43, 95%CI 0.14, 1.34 among Black women). Conclusions Despite the biologic plausibility that antihistamine use may influence pregnancy outcomes, we did not detect evidence of an association with SAB or PTB. These data demonstrate the utility of large prospective cohorts for evaluating drug safety in pregnancy when concerns are raised from animal models. Copyright © 2014 John Wiley & Sons, Ltd.

Journal

Pharmacoepidemiology and Drug Safety – Wiley

Published: Jan 1, 2014

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