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Figure 1. Comparison with plasma TARC level in healthy volunteers (NORMAL) and the patients with atopic dermatitis (AD), bronchial asthma (BA) and allergic rhinitis (AR) -
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- Publisher
- Wiley
- Copyright
- Copyright © 2002 Wiley Subscription Services, Inc., A Wiley Company
- ISSN
- 0105-4538
- eISSN
- 1398-9995
- DOI
- 10.1034/j.1398-9995.2002.1n3503.x
- Publisher site
- See Article on Publisher Site
Abstract
T hymus activation‐regulated chemokine (TARC/CCL17) is a member of CC chemokine that is transiently expressed in phytohemagglutinin‐stimulated peripheral blood mononuclear cells (PBMC) and constitutively and selectively in the thymus ( 1 ). Recently it has been reported that the TARC receptor CCR4 is selectively expressed in T helper (Th2) cells and that serum TARC level is associated with disease activity in atopic dermatitis ( 2,3 ). This is the first report describing plasma TARC levels in patients with bronchial asthma and allergic rhinitis. Plasma TARC concentration was measured by ELISA (R&D systems, MN, USA) in 50 healthy volunteers who previously showed no allergic symptoms, 30 patients with atopic dermatitis, 64 patients with bronchial asthma, and 22 patients with allergic rhinitis. In this study patients treated with drugs were excluded. The mean concentration of TARC in healthy volunteers was 31.9 pg/ml (SD14.8); significantly higher than in non‐allergic volunteers, and than patients with atopic dermatitis ( p < 0.001), bronchial asthma ( p < 0.001), and allergic rhinitis ( p < 0.001): 325 pg/ml (287), 271 pg/ml (264), and 147 pg/ml (101), respectively, ( Fig. 1 ). IgE levels and numbers of peripheral eosinophils were not necessarily correlated with the
Journal
Allergy – Wiley
Published: Feb 1, 2002