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Helicobacter species and in vivo models of gastrointestinal cancer

Helicobacter species and in vivo models of gastrointestinal cancer SUMMARY Although gastric cancer is an uncommon spontaneous neoplasm of laboratory animal species, rodents, and to a lesser extent other animals, have been used in chemically induced gastric carcinogenesis studies for decades. The role of diet in preventing or promoting gastric cancer has also been addressed in animal models. With the discovery of Helicobacter pylori and its causative role in gastric disease in humans, several animal models have been described for Helicobacter spp.induced gastric disease, and in selected models, development of gastric and hepatic cancer. This review has attempted to highlight salient features of Helicobacter models and how these observations may be interpreted in light of data obtained from chemical carcinogenesis and nutritional studies. Further insight into mechanisms of Helicobacter-induced cancer should evolve by combining and comparing relevant features of these in vivo models. INTRODUCTION Gastric carcinoma remains an important malignancy of the gastrointestinal tract and a significant cause of cancer deaths in humans worldwide, even though gastric cancer rates have been declining in developed countries in recent decades.1,2 The incidence of gastric carcinoma varies widely in different populations and even within subpopulations of the same geographical area and by some estimations continues to increase in developing countries http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Alimentary Pharmacology & Therapeutics Wiley

Helicobacter species and in vivo models of gastrointestinal cancer

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References (185)

Publisher
Wiley
Copyright
Copyright © 1998 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0269-2813
eISSN
1365-2036
DOI
10.1111/j.1365-2036.1998.00008.x
Publisher site
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Abstract

SUMMARY Although gastric cancer is an uncommon spontaneous neoplasm of laboratory animal species, rodents, and to a lesser extent other animals, have been used in chemically induced gastric carcinogenesis studies for decades. The role of diet in preventing or promoting gastric cancer has also been addressed in animal models. With the discovery of Helicobacter pylori and its causative role in gastric disease in humans, several animal models have been described for Helicobacter spp.induced gastric disease, and in selected models, development of gastric and hepatic cancer. This review has attempted to highlight salient features of Helicobacter models and how these observations may be interpreted in light of data obtained from chemical carcinogenesis and nutritional studies. Further insight into mechanisms of Helicobacter-induced cancer should evolve by combining and comparing relevant features of these in vivo models. INTRODUCTION Gastric carcinoma remains an important malignancy of the gastrointestinal tract and a significant cause of cancer deaths in humans worldwide, even though gastric cancer rates have been declining in developed countries in recent decades.1,2 The incidence of gastric carcinoma varies widely in different populations and even within subpopulations of the same geographical area and by some estimations continues to increase in developing countries

Journal

Alimentary Pharmacology & Therapeutics – Wiley

Published: Feb 1, 1998

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