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Michael Soldan, Gerd Nagel, Marga Losekam, Michael Ernst, Edmund Maser (1999)
Interindividual variability in the expression and NNK carbonyl reductase activity of 11beta-hydroxysteroid dehydrogenase 1 in human lung.Cancer letters, 145 1-2
S. Hecht, C. Chen, T. Ohmori, D. Hoffmann (1980)
Comparative carcinogenicity in F344 rats of the tobacco-specific nitrosamines, N'-nitrosonornicotine and 4-(N-methyl-N-nitrosamino)-1-(3-pyridyl)-1-butanone.Cancer research, 40 2
H. Gao, J. Chen, J. Stewart, B. Song, C. Rayappa, W. Whong, T. Ong (1997)
Distribution of p53 and K-ras mutations in human lung cancer tissues.Carcinogenesis, 18 3
E. Maser, E. Richter, J. Friebertshäuser (1996)
The identification of 11 beta-hydroxysteroid dehydrogenase as carbonyl reductase of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.European journal of biochemistry, 238 2
K. Macé, E.D Bowman, P. Vautravers, P.G Shields, C.C Harris, A.M.A Pfeifer (1998)
Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissues.European journal of cancer, 34 6
A. Atalla, U. Breyer‐Pfaff, E. Maser (2000)
Purification and characterization of oxidoreductases-catalyzing carbonyl reduction of the tobacco-specific nitrosamine 4-methylnitrosamino-1-(3-pyridyl)-1-butanone (NNK) in human liver cytosolXenobiotica, 30
R. Doll, R. Peto (1981)
The causes of cancer: quantitative estimates of avoidable risks of cancer in the United States today.Journal of the National Cancer Institute, 66 6
Sharon, E. Murphy, Steven, G., Carmella, Ali, M., Idris, Dietrich, Hoffmann (1994)
Uptake and metabolism of carcinogenic levels of tobacco-specific nitrosamines by Sudanese snuff dippers.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 3 5
J. Schulze, E. Richter, U. Binder, W. Zwickenpflug (1992)
Biliary excretion of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the rat.Carcinogenesis, 13 11
Atalla (1999)
Carbonyl reductase and three aldo-keto reductases responsible for NNK carbonyl reduction in human liver cytosolNaunyn Schmiedebergs Arch. Pharmacol. Suppl., 359
E. Maser, Benno Stinner, Awad Atalla (2000)
Carbonyl reduction of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) by cytosolic enzymes in human liver and lung.Cancer letters, 148 2
S. Carmella, S. Akerkar, J. Richie, S. Hecht (1995)
Intraindividual and interindividual differences in metabolites of the tobacco-specific lung carcinogen 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in smokers' urine.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 4 6
B. Wermuth, K. Bohren, G. Heinemann, J. Wartburg, K. Gabbay (1988)
Human carbonyl reductase. Nucleotide sequence analysis of a cDNA and amino acid sequence of the encoded protein.The Journal of biological chemistry, 263 31
Mace (1998)
Characterisation of xenobiotic-metabolising enzyme expression in human bronchial mucosa and peripheral lung tissuesBiochem. Pharmacol., 34
H. Jörnvall, B. Persson, M. Krook, S. Atrian, R. Gonzàlez-Duarte, J. Jeffery, D. Ghosh (1995)
Short-chain dehydrogenases/reductases (SDR).Biochemistry, 34 18
Edmund Maser (1995)
Xenobiotic carbonyl reduction and physiological steroid oxidoreduction. The pluripotency of several hydroxysteroid dehydrogenases.Biochemical pharmacology, 49 4
E. Maser (1998)
11Beta-hydroxysteroid dehydrogenase responsible for carbonyl reduction of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in mouse lung microsomes.Cancer research, 58 14
S. Hecht, N. Trushin, Cheri Reid-Quinn, E. Burak, Ann Jones, J. Southers, C. Gombar, S. Carmella, L. Anderson, J. Rice (1993)
Metabolism of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in the patas monkey: pharmacokinetics and characterization of glucuronide metabolites.Carcinogenesis, 14 2
Theresa Smith, G. Stoner, Chung Yang (1995)
Activation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in human lung microsomes by cytochromes P450, lipoxygenase, and hydroperoxides.Cancer research, 55 23
S. Hecht (1994)
Metabolic activation and detoxification of tobacco-specific nitrosamines--a model for cancer prevention strategies.Drug metabolism reviews, 26 1-2
Awad Atalla, E. Maser (1999)
Carbonyl reduction of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in cytosol of mouse liver and lung.Toxicology, 139 1-2
S. Belinsky, D. Swafford, G. Finch, C. Mitchell, G. Kelly, F. Hahn, Marshall Anderson, Kristen Nikula (1997)
Alterations in the K-ras and p53 genes in rat lung tumors.Environmental Health Perspectives, 105
Theresa Smith, Anita Liao, Yuan Liu, Butler Jones, L. Anderson, C. Yang (1997)
Enzymes involved in the bioactivation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in patas monkey lung and liver microsomes.Carcinogenesis, 18 8
C. Crespi, B. Penman, H. Gelboin, F. Gonzalez (1991)
A tobacco smoke-derived nitrosamine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, is activated by multiple human cytochrome P450s including the polymorphic human cytochrome P4502D6.Carcinogenesis, 12 7
A. Blum, H. Martin, E. Maser (2000)
Human 11β-hydroxysteroid dehydrogenase 1/carbonyl reductase : recombinant expression in the yeast Pichia pastoris and Escherichia coliToxicology, 144
G. Bowden, V. McGovern, N. Ossanna, H. Rosenthal (1982)
Concentration dependent alterations of DNA replication initiation and elongation by benzo[a]pyrene diol epoxide.Carcinogenesis, 3 5
S. Carmella, A. Borukhova, S. Akerkar, S. Hecht (1997)
Analysis of human urine for pyridine-N-oxide metabolites of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, a tobacco-specific lung carcinogen.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, 6 2
S. Hecht, S. Carmella, S. Murphy, S. Akerkar, K. Brunnemann, D. Hoffmann (1993)
A tobacco-specific lung carcinogen in the urine of men exposed to cigarette smoke.The New England journal of medicine, 329 21
M. Bradford (1976)
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding.Analytical biochemistry, 72
Maser (1997)
Stress, hormonal changes, alcohol, food constituents and drugs: factors that advance the incidence of tobacco smoke-related cancer?Trends Pharmacol. Sci., 18
A. Castonguay, A. Castonguay, D. Lin, D. Lin, G. Stoner, G. Stoner, P. Radok, P. Radok, K. Furuya, S. Hecht, H. Schut, J. Klaunig (1983)
Comparative carcinogenicity in A/J mice and metabolism by cultured mouse peripheral lung of N'-nitrosonornicotine, 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone, and their analogues.Cancer research, 43 3
S. Carmella, S. Akerkar, S. Hecht (1993)
Metabolites of the tobacco-specific nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in smokers' urine.Cancer research, 53 4
Edmund Maser (1997)
Stress, hormonal changes, alcohol, food constituents and drugs: factors that advance the incidence of tobacco smoke-related cancer?Trends in pharmacological sciences, 18 8
Theresa Smith, Zuyu Guo, F. Gonzalez, F. Guengerich, G. Stoner, C. Yang (1992)
Metabolism of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in human lung and liver microsomes and cytochromes P-450 expressed in hepatoma cells.Cancer research, 52 7
A. Wu, E. Fontham, P. Reynolds, R. Greenberg, P. Buffler, J. Liff, P. Boyd, P. Correa (1996)
Family history of cancer and risk of lung cancer among lifetime nonsmoking women in the United States.American journal of epidemiology, 143 6
S. London, A. Daly, J. Leathart, W. Navidi, C. Carpenter, J. Idle (1997)
Genetic polymorphism of CYP2D6 and lung cancer risk in African-Americans and Caucasians in Los Angeles County.Carcinogenesis, 18 6
Chemico-Biological Interactions – Pubmed
Published: May 10, 2001
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