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- Publisher
- Springer Journals
- Copyright
- Copyright © The Author(s), under exclusive licence to the Japan Antibiotics Research Association 2020
- ISSN
- 0021-8820
- eISSN
- 1881-1469
- DOI
- 10.1038/s41429-020-0281-x
- Publisher site
- See Article on Publisher Site
Abstract
Chaetomium globosum is a filamentous fungus from which we have previously isolated a series of interesting natural products. Here, we isolated a previously unknown natural product from the culture of C. globosum. Through spectroscopic and crystallographic characterization, we determined the compound to be a new dimerized azaphilone-type product which we termed cochliodone J (1). Furthermore, our investigation into the biological activity of the natural product determined that 1 was cytotoxic to human cervix carcinoma HeLa cells with an IC50 of 17.3 µM. Lastly, a plausible biosynthetic mechanism for 1 is suggested based on our previous study on the biosynthesis of a closely related compound, cochliodone A (2).
Journal
The Journal of Antibiotics – Springer Journals
Published: May 5, 2020