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- Publisher
- Wiley
- Copyright
- "Copyright © 2009 Wiley Subscription Services, Inc., A Wiley Company"
- ISSN
- 0007-1188
- eISSN
- 1476-5381
- DOI
- 10.1111/j.1476-5381.2009.00389.x
- pmid
- 19775282
- Publisher site
- See Article on Publisher Site
Abstract
Background and purpose: γ‐Secretase inhibitors (GSIs) block NOTCH receptor cleavage and pathway activation and have been under clinical evaluation for the treatment of malignancies such as T‐cell acute lymphoblastic leukaemia (T‐ALL). The ability of GSIs to decrease T‐ALL cell viability in vitro is a slow process requiring >8 days, however, such treatment durations are not well tolerated in vivo. Here we study GSI's effect on tumour and normal cellular processes to optimize dosing regimens for anti‐tumour efficacy.
Journal
British Journal of Pharmacology – Wiley
Published: Nov 1, 2009
Keywords: ; ; ; ;