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- Publisher
- Springer Journals
- Copyright
- Copyright © 2008 by Springer Science+Business Media, LLC
- Subject
- Biomedicine; Medical Microbiology ; Internal Medicine ; Infectious Diseases; Immunology
- ISSN
- 0271-9142
- eISSN
- 1573-2592
- DOI
- 10.1007/s10875-008-9239-7
- pmid
- 18810613
- Publisher site
- See Article on Publisher Site
Abstract
J Clin Immunol (2008) 28:660–670 DOI 10.1007/s10875-008-9239-7 Amit Awasthi & Gopal Murugaiyan & Vijay K. Kuchroo Received: 17 July 2008 /Accepted: 24 July 2008 /Published online: 23 September 2008 Springer Science + Business Media, LLC 2008 . . . Abstract Keywords Inflammation T helper cells regulatory Tcells Introduction Over two decades ago, T helper cells were autoimmunity Th17 cells classified into its functional subsets. Soon after the classical observation of Mosmann et al., immunologists agreed to Abbreviations accept the Th1/Th2 paradigm of the T helper subsets. Each Th T helper subset is not only characterized by its specific cytokines IL Interleukin pattern and effector functions but also by their properties to IFN-γ Interferon gamma counter regulate each other’s functions. This classification TGF-β Transforming growth factor beta helped to understand the complex principles of T helper cell Tr1 T-regulatory cells type-1 biology and allowed us to comprehend different immune T-regs Regulatory T cells reactions in context of Th1 and Th2 subsets. EAE experimental autoimmune encephalomyelitis Discussion Although Th1 subsets thought to be the crucial MS Multiple sclerosis player for most of the organ-specific autoimmune diseases CIA Collagen induced arthritis like multiple sclerosis and type-1 diabetes but the loss of CNS
Journal
Journal of Clinical Immunology – Springer Journals
Published: Sep 23, 2008