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TGF-β superfamily, molecular signaling and biomimetic features for bone regeneration: historical perspectives and future applications

TGF-β superfamily, molecular signaling and biomimetic features for bone regeneration: historical... Updates Surg (2015) 67:321–323 DOI 10.1007/s13304-015-0297-0 LETTER TO THE EDITOR TGF-b superfamily, molecular signaling and biomimetic features for bone regeneration: historical perspectives and future applications 1 2 3 4 • • • • Alessandro Mangano Alberto Mangano Georgios D. Lianos Monica Picone Gianlorenzo Dionigi Received: 28 March 2015 / Accepted: 4 April 2015 / Published online: 21 April 2015 Italian Society of Surgery (SIC) 2015 Keywords TGF-b  BMPs/OPs  Bone regeneration  effectors are known as Smad proteins. Furthermore, in- Tissue engineering  Scaffold  CAD/CAM hibitory Smads have been described and are responsible for inhibiting the activation of the related receptor [2]. The transduction pathway mainly relies on the trans- The transforming growth factor-b superfamily membrane serine/threonine kinase receptors type I and type and its signaling downstream pathway II. What is more, it is widely accepted that TGF-b ligands bind to the type II receptor, which afterward recruits a type I The transforming growth factor-b (TGF-b) superfamily is a receptor. The creation of a complex between type II and group of secreted polypeptide growth factors that can be type I receptors activates a phosphorylation process that in categorized and divided into three main families: TGF-bs, turns allows http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Updates in Surgery Springer Journals

TGF-β superfamily, molecular signaling and biomimetic features for bone regeneration: historical perspectives and future applications

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References (5)

Publisher
Springer Journals
Copyright
Copyright © 2015 by Italian Society of Surgery (SIC)
Subject
Medicine & Public Health; Surgery
ISSN
2038-131X
eISSN
2038-3312
DOI
10.1007/s13304-015-0297-0
pmid
25895572
Publisher site
See Article on Publisher Site

Abstract

Updates Surg (2015) 67:321–323 DOI 10.1007/s13304-015-0297-0 LETTER TO THE EDITOR TGF-b superfamily, molecular signaling and biomimetic features for bone regeneration: historical perspectives and future applications 1 2 3 4 • • • • Alessandro Mangano Alberto Mangano Georgios D. Lianos Monica Picone Gianlorenzo Dionigi Received: 28 March 2015 / Accepted: 4 April 2015 / Published online: 21 April 2015 Italian Society of Surgery (SIC) 2015 Keywords TGF-b  BMPs/OPs  Bone regeneration  effectors are known as Smad proteins. Furthermore, in- Tissue engineering  Scaffold  CAD/CAM hibitory Smads have been described and are responsible for inhibiting the activation of the related receptor [2]. The transduction pathway mainly relies on the trans- The transforming growth factor-b superfamily membrane serine/threonine kinase receptors type I and type and its signaling downstream pathway II. What is more, it is widely accepted that TGF-b ligands bind to the type II receptor, which afterward recruits a type I The transforming growth factor-b (TGF-b) superfamily is a receptor. The creation of a complex between type II and group of secreted polypeptide growth factors that can be type I receptors activates a phosphorylation process that in categorized and divided into three main families: TGF-bs, turns allows

Journal

Updates in Surgery – Springer Journals

Published: Apr 21, 2015

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