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- Publisher
- Springer Journals
- Copyright
- Copyright © 2017 by Macmillan Publishers Limited, part of Springer Nature. All rights reserved.
- Subject
- Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- DOI
- 10.1038/nature21405
- Publisher site
- See Article on Publisher Site
Abstract
Introducing chimeric antigen receptors into the endogenous T-cell receptor locus reduces tonic signalling, averts accelerated T-cell differentiation and delays T-cell exhaustion, leading to enhanced function and anti-tumour efficacy compared to random integrations.
Journal
Nature – Springer Journals
Published: Feb 22, 2017