Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits

Jacqueline M Lane; Jingjing Liang; Irma Vlasac; Simon G Anderson; David A Bechtold; Jack Bowden; Richard Emsley; Shubhroz Gill; Max A Little; Annemarie I Luik; Andrew Loudon; Frank A J L Scheer; Shaun M Purcell; Simon D Kyle; Deborah A Lawlor; Xiaofeng Zhu; Susan Redline; David W Ray; Martin K Rutter; Richa Saxena

doi:10.1038/ng.3749

Richa Saxena and colleagues report genome-wide association analyses of sleep disturbance traits in the UK Biobank cohort. They discover loci associated with insomnia symptoms and excessive daytime sleepiness and identify genetic correlations with several neuropsychiatric and metabolic traits.

Loading next page...

References (105)

R. Rosenberg, D. Seiden, Steven Hull, M. Erman, H. Schwartz, C. Anderson, Warren Prosser, W. Shanahan, Matilde Sánchez, E. Chuang, T. Roth (2008)
APD125, a selective serotonin 5-HT(2A) receptor inverse agonist, significantly improves sleep maintenance in primary insomnia.
Sleep, 31 12
S. Ripke, B. Neale, A. Corvin, J. Walters, Kai-How Farh, P. Holmans, Phil Lee, B. Bulik-Sullivan, D. Collier, Hailiang Huang, T. Pers, I. Agartz, E. Agerbo, M. Albus, Madeline Alexander, F. Amin, S. Bacanu, M. Begemann, R. Belliveau, J. Bene, Sarah Bergen, Elizabeth Bevilacqua, T. Bigdeli, D. Black, R. Bruggeman, N. Buccola, R. Buckner, W. Byerley, W. Cahn, Guiqing Cai, D. Campion, R. Cantor, V. Carr, N. Carrera, S. Catts, K. Chambert, R. Chan, Ronald Chan, E. Chen, Wei Cheng, E. Cheung, S. Chong, C. Cloninger, D. Cohen, Nadine Cohen, P. Cormican, N. Craddock, J. Crowley, D. Curtis, M. Davidson, K. Davis, F. Degenhardt, J. Favero, D. Demontis, D. Dikeos, T. Dinan, S. Djurovic, G. Donohoe, Elodie Drapeau, J. Duan, F. Dudbridge, N. Durmishi, P. Eichhammer, J. Eriksson, V. Escott-Price, L. Essioux, A. Fanous, M. Farrell, J. Frank, L. Franke, R. Freedman, N. Freimer, M. Friedl, J. Friedman, M. Fromer, G. Genovese, L. Georgieva, I. Giegling, P. Giusti-Rodríguez, S. Godard, J. Goldstein, V. Golimbet, S. Gopal, J. Gratten, L. Haan, C. Hammer, M. Hamshere, M. Hansen, T. Hansen, V. Haroutunian, A. Hartmann, F. Henskens, S. Herms, J. Hirschhorn, P. Hoffmann, A. Hofman, M. Hollegaard, D. Hougaard, M. Ikeda, I. Joa, A. Julià, R. Kahn, L. Kalaydjieva, Sena Karachanak-Yankova, J. Karjalainen, D. Kavanagh, M. Keller, J. Kennedy, A. Khrunin, Yunjung Kim, J. Kloviņš, J. Knowles, B. Konte, V. Kučinskas, Z. Kučinskienė, Hana Kuzelova-Ptackova, A. Kähler, C. Laurent, Jimmy Lee, S. Lee, S. Legge, B. Lerer, Miaoxin Li, Tao Li, K. Liang, J. Lieberman, S. Limborska, C. Loughland, J. Lubiński, J. Lönnqvist, M. Macek, P. Magnusson, B. Maher, W. Maier, J. Mallet, S. Marsal, M. Mattheisen, M. Mattingsdal, R. McCarley, C. Mcdonald, A. McIntosh, S. Meier, C. Meijer, B. Melegh, I. Melle, R. Mesholam-Gately, A. Metspalu, P. Michie, L. Milani, V. Milanova, Y. Mokrab, D. Morris, O. Mors, K. Murphy, R. Murray, I. Myin‐Germeys, B. Müller-Myhsok, M. Nelis, I. Nenadić, D. Nertney, G. Nestadt, K. Nicodemus, L. Nikitina-Zake, L. Nisenbaum, Annelie Nordin, E. O'callaghan, C. O’Dushlaine, F. O’Neill, Sang-Yun Oh, A. Olincy, L. Olsen, J. os, C. Pantelis, G. Papadimitriou, S. Papiol, E. Parkhomenko, M. Pato, T. Paunio, M. Pejović-Milovančević, D. Perkins, O. Pietiläinen, J. Pimm, A. Pocklington, J. Powell, A. Price, A. Pulver, S. Purcell, D. Quested, H. Rasmussen, A. Reichenberg, M. Reimers, A. Richards, J. Roffman, P. Roussos, D. Ruderfer, V. Salomaa, A. Sanders, U. Schall, C. Schubert, T. Schulze, S. Schwab, E. Scolnick, R. Scott, L. Seidman, Jianxin Shi, E. Sigurdsson, T. Silagadze, J. Silverman, K. Sim, P. Slominsky, J. Smoller, H. So, C. Spencer, E. Stahl, H. Stefánsson, S. Steinberg, E. Stogmann, R. Straub, E. Strengman, J. Strohmaier, T. Stroup, M. Subramaniam, J. Suvisaari, D. Svrakic, J. Szatkiewicz, E. Söderman, S. Thirumalai, D. Toncheva, S. Tosato, J. Veijola, J. Waddington, D. Walsh, Dai Wang, Qiang Wang, B. Webb, M. Weiser, D. Wildenauer, N. Williams, Stephanie Williams, S. Witt, A. Wolen, Emily Wong, B. Wormley, H. Xi, C. Zai, Xue-bin Zheng, F. Zimprich, N. Wray, K. Stefánsson, P. Visscher, R. Adolfsson, O. Andreassen, D. Blackwood, E. Bramon, J. Buxbaum, A. Børglum, S. Cichon, A. Darvasi, E. Domenici, H. Ehrenreich, T. Esko, P. Gejman, M. Gill, H. Gurling, C. Hultman, N. Iwata, A. Jablensky, E. Jönsson, K. Kendler, G. Kirov, J. Knight, T. Lencz, D. Levinson, Qingqin Li, Jianjun Liu, A. Malhotra, S. Mccarroll, A. McQuillin, J. Moran, P. Mortensen, B. Mowry, M. Nöthen, R. Ophoff, M. Owen, A. Palotie, C. Pato, T. Petryshen, D. Posthuma, M. Rietschel, B. Riley, D. Rujescu, P. Sham, P. Sklar, D. Clair, D. Weinberger, J. Wendland, T. Werge, M. Daly, P. Sullivan, M. O’Donovan (2014)
Biological Insights From 108 Schizophrenia-Associated Genetic Loci
Nature, 511
S. Stranges, W. Tigbe, F. Gómez-Olivé, M. Thorogood, N. Kandala (2012)
Sleep problems: an emerging global epidemic? Findings from the INDEPTH WHO-SAGE study among more than 40,000 older adults from 8 countries across Africa and Asia.
Sleep, 35 8
C. Willer, Yun Li, G. Abecasis (2010)
METAL: fast and efficient meta-analysis of genomewide association scans
Bioinformatics, 26
Maeva Patry, R. Teinturier, D. Goehrig, C. Zetu, Doriane Ripoche, In‐San Kim, P. Bertolino, A. Hennino (2015)
βig-h3 Represses T-Cell Activation in Type 1 Diabetes
Diabetes, 64
E. Tasali, R. Leproult, D. Ehrmann, E. Cauter (2008)
Slow-wave sleep and the risk of type 2 diabetes in humans
Proceedings of the National Academy of Sciences, 105
S. Davidson, K. Miller, A. Dowell, A. Gildea, A. MacKenzie (2006)
A remote and highly conserved enhancer supports amygdala specific expression of the gene encoding the anxiogenic neuropeptide substance-P
Molecular Psychiatry, 11
Xiaofeng Zhu, Tao Feng, Tao Feng, B. Tayo, Jingjing Liang, J. Young, N. Franceschini, Jennifer Smith, L. Yanek, Yan Sun, T. Edwards, Wei Chen, M. Nalls, Ervin Fox, M. Sale, E. Bottinger, C. Rotimi, Yongmei Liu, B. McKnight, Kiang Liu, D. Arnett, Aravinda Chakravati, R. Cooper, S. Redline (2015)
Meta-analysis of correlated traits via summary statistics from GWASs with an application in hypertension.
American journal of human genetics, 96 1
E. Schulte, M. Kousi, P. Tan, E. Tilch, Franziska Knauf, P. Lichtner, C. Trenkwalder, B. Högl, B. Frauscher, K. Berger, I. Fietze, M. Hornyak, W. Oertel, C. Bachmann, A. Zimprich, A. Peters, C. Gieger, T. Meitinger, B. Müller-Myhsok, N. Katsanis, J. Winkelmann (2014)
Targeted resequencing and systematic in vivo functional testing identifies rare variants in MEIS1 as significant contributors to restless legs syndrome.
American journal of human genetics, 95 1
Hyatt Moore, J. Winkelmann, Ling Lin, L. Finn, P. Peppard, E. Mignot (2014)
Periodic leg movements during sleep are associated with polymorphisms in BTBD9, TOX3/BC034767, MEIS1, MAP2K5/SKOR1, and PTPRD.
Sleep, 37 9
Bryan Howie, P. Donnelly, J. Marchini (2009)
A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies
PLoS Genetics, 5
F. Casares, R. Mann (1998)
Control of antennal versus leg development in Drosophila
Nature, 392
NE Allen, C Sudlow, T Peakman, R Collins (2014)
UK Biobank. UK Biobank data: come and get it
Sci. Transl. Med., 6
C. Marshall, D. Howrigan, D. Merico, B. Thiruvahindrapuram, Wenting Wu, Douglas Greer, Danny Antaki, Aniket Shetty, P. Holmans, D. Pinto, Madhusudan Gujral, W. Brandler, Dheeraj Malholtra, Zhouzhi Wang, Karin Fajarado, S. Ripke, I. Agartz, E. Agerbo, M. Albus, Madeline Alexander, F. Amin, J. Atkins, S. Bacanu, R. Belliveau, Sarah Bergen, Marcelo Bertalan, Elizabeth Bevilacqua, T. Bigdeli, D. Black, R. Bruggeman, N. Buccola, R. Buckner, B. Bulik-Sullivan, W. Byerley, W. Cahn, Guiqing Cai, M. Cairns, D. Campion, R. Cantor, V. Carr, N. Carrera, S. Catts, K. Chambert, Wei Cheng, C. Cloninger, D. Cohen, P. Cormican, N. Craddock, B. Crespo-Facorro, J. Crowley, D. Curtis, M. Davidson, K. Davis, F. Degenhardt, J. Favero, L. DeLisi, D. Demontis, D. Dikeos, T. Dinan, S. Djurovic, G. Donohoe, Elodie Drapeau, J. Duan, F. Dudbridge, P. Eichhammer, J. Eriksson, V. Escott-Price, L. Essioux, A. Fanous, Kai-How Farh, M. Farrell, J. Frank, L. Franke, R. Freedman, N. Freimer, J. Friedman, A. Forstner, M. Fromer, G. Genovese, L. Georgieva, E. Gershon, I. Giegling, P. Giusti-Rodríguez, S. Godard, J. Goldstein, J. Gratten, L. Haan, M. Hamshere, M. Hansen, T. Hansen, V. Haroutunian, A. Hartmann, F. Henskens, S. Herms, J. Hirschhorn, P. Hoffmann, A. Hofman, M. Hollegaard, D. Hougaard, Hailiang Huang, M. Ikeda, I. Joa, A. Kähler, R. Kahn, L. Kalaydjieva, J. Karjalainen, D. Kavanagh, M. Keller, B. Kelly, J. Kennedy, Yunjung Kim, J. Knowles, B. Konte, C. Laurent, Phil Lee, S. Lee, S. Legge, B. Lerer, D. Levy, K. Liang, J. Lieberman, J. Lonnqvist, C. Loughland, P. Magnusson, B. Maher, W. Maier, J. Mallet, M. Mattheisen, M. Mattingsdal, R. McCarley, C. Mcdonald, A. McIntosh, S. Meier, C. Meijer, I. Melle, R. Mesholam-Gately, A. Metspalu, P. Michie, L. Milani, V. Milanova, Y. Mokrab, D. Morris, O. Mors, B. Müller-Myhsok, K. Murphy, R. Murray, I. Myin‐Germeys, I. Nenadić, D. Nertney, G. Nestadt, K. Nicodemus, L. Nisenbaum, Annelie Nordin, E. O'callaghan, C. O’Dushlaine, Sang-Yun Oh, A. Olincy, L. Olsen, F. O’Neill, J. Os, C. Pantelis, G. Papadimitriou, E. Parkhomenko, M. Pato, T. Paunio, D. Perkins, T. Pers, O. Pietiläinen, J. Pimm, A. Pocklington, J. Powell, A. Price, A. Pulver, S. Purcell, D. Quested, H. Rasmussen, A. Reichenberg, M. Reimers, A. Richards, J. Roffman, P. Roussos, D. Ruderfer, V. Salomaa, A. Sanders, A. Savitz, U. Schall, T. Schulze, S. Schwab, E. Scolnick, R. Scott, L. Seidman, Jianxin Shi, J. Silverman, J. Smoller, E. Söderman, C. Spencer, E. Stahl, E. Strengman, J. Strohmaier, T. Stroup, J. Suvisaari, D. Svrakic, J. Szatkiewicz, S. Thirumalai, P. Tooney, J. Veijola, P. Visscher, J. Waddington, D. Walsh, B. Webb, M. Weiser, D. Wildenauer, N. Williams, Stephanie Williams, S. Witt, A. Wolen, B. Wormley, N. Wray, J. Wu, C. Zai, R. Adolfsson, O. Andreassen, D. Blackwood, A. Børglum, E. Bramon, J. Buxbaum, S. Cichon, D. Collier, A. Corvin, M. Daly, A. Darvasi, E. Domenici, T. Esko, P. Gejman, M. Gill, H. Gurling, C. Hultman, N. Iwata, A. Jablensky, E. Jönsson, K. Kendler, G. Kirov, J. Knight, D. Levinson, Qingqin Li, S. Mccarroll, A. McQuillin, J. Moran, P. Mortensen, B. Mowry, M. Nöthen, R. Ophoff, M. Owen, A. Palotie, C. Pato, T. Petryshen, D. Posthuma, M. Rietschel, B. Riley, D. Rujescu, P. Sklar, D. Clair, J. Walters, T. Werge, P. Sullivan, M. O’Donovan, S. Scherer, B. Neale, J. Sebat (2016)
A contribution of novel CNVs to schizophrenia from a genome-wide study of 41,321 subjects: CNV Analysis Group and the Schizophrenia Working Group of the Psychiatric Genomics Consortium
bioRxiv
D. Altshuler, R. Gibbs, L. Peltonen, E. Dermitzakis, S. Schaffner, F. Yu, P. Bonnen, P. Bakker, P. Deloukas, S. Gabriel, R. Gwilliam, S. Hunt, M. Inouye, Xiaoming Jia, A. Palotie, Melissa Parkin, P. Whittaker, K. Chang, A. Hawes, L. Lewis, Yanru Ren, D. Wheeler, D. Muzny, Chris Barnes, K. Darvishi, M. Hurles, Joshua Korn, K. Kristiansson, Charles Lee, Steven McCarrol, J. Nemesh, A. Keinan, S. Montgomery, Samuela Pollack, A. Price, N. Soranzo, C. Gonzaga‐Jauregui, V. Anttila, W. Brodeur, M. Daly, S. Leslie, G. McVean, L. Moutsianas, Huy Nguyen, Qingrun Zhang, Mohammed Ghori, R. McGinnis, W. McLaren, F. Takeuchi, S. Grossman, I. Shlyakhter, E. Hostetter, Pardis Sabeti, C. Adebamowo, M. Foster, D. Gordon, J. Licinio, M. Manca, P. Marshall, I. Matsuda, D. Ngare, V. Wang, Deepa Reddy, C. Rotimi, C. Royal, R. Sharp, Changqing Zeng, L. Brooks, J. Mcewen (2010)
Integrating common and rare genetic variation in diverse human populations
Nature, 467
Enda Byrne, P. Gehrman, M. Trzaskowski, H. Tiemeier, A. Pack (2016)
Genetic Correlation Analysis Suggests Association between Increased Self-Reported Sleep Duration in Adults and Schizophrenia and Type 2 Diabetes.
Sleep, 39 10
J. Fernandez-Mendoza, A. Vgontzas (2013)
Insomnia and its Impact on Physical and Mental Health
Current Psychiatry Reports, 15
Yuxin Fan, Tera Newman, Elena Linardopoulou, B. Trask (2002)
Gene content and function of the ancestral chromosome fusion site in human chromosome 2q13-2q14.1 and paralogous regions.
Genome research, 12 11
J. Poulin, S. Chouinard, T. Pampoulova, Y. Lecomte, E. Stip, R. Godbout (2010)
Sleep habits in middle-aged, non-hospitalized men and women with schizophrenia: A comparison with healthy controls
Psychiatry Research, 179
S. Peirson, H. Oster, Sarah Jones, M. Leitges, M. Hankins, R. Foster (2007)
Microarray Analysis and Functional Genomics Identify Novel Components of Melanopsin Signaling
Current Biology, 17
K. Wulff, D. Dijk, B. Middleton, R. Foster, E. Joyce (2012)
Sleep and circadian rhythm disruption in schizophrenia†
The British Journal of Psychiatry, 200
Alexis Edwards, F. Aliev, L. Bierut, K. Bucholz, H. Edenberg, V. Hesselbrock, J. Kramer, S. Kuperman, J. Nurnberger, M. Schuckit, B. Porjesz, D. Dick (2012)
Genome-wide association study of comorbid depressive syndrome and alcohol dependence
Psychiatric Genetics, 22
P. Burton, D. Clayton, L. Cardon, N. Craddock, P. Deloukas, A. Duncanson, D. Kwiatkowski, M. McCarthy, W. Ouwehand, N. Samani, J. Todd, P. Donnelly, J. Barrett, D. Davison, D. Easton, David Evans, H. Leung, J. Marchini, A. Morris, C. Spencer, M. Tobin, A. Attwood, J. Boorman, B. Cant, Ursula Everson, Judith Hussey, J. Jolley, A. Knight, K. Koch, Elizabeth Meech, S. Nutland, C. Prowse, H. Stevens, N. Taylor, G. Walters, N. Walker, N. Watkins, T. Winzer, Richard Jones, W. McArdle, S. Ring, D. Strachan, M. Pembrey, G. Breen, D. Clair, S. Caesar, K. Gordon-Smith, L. Jones, C. Fraser, E. Green, D. Grozeva, M. Hamshere, P. Holmans, I. Jones, G. Kirov, V. Moskvina, I. Nikolov, M. O’Donovan, M. Owen, D. Collier, A. Elkin, A. Farmer, R. Williamson, P. McGuffin, A. Young, I. Ferrier, S. Ball, A. Balmforth, J. Barrett, D. Bishop, M. Iles, A. Maqbool, N. Yuldasheva, A. Hall, P. Braund, R. Dixon, M. Mangino, Suzanne Stevens, J. Thompson, F. Bredin, M. Tremelling, M. Parkes, H. Drummond, C. Lees, E. Nimmo, J. Satsangi, S. Fisher, A. Forbes, C. Lewis, Clive Onnie, N. Prescott, J. Sanderson, C. Mathew, J. Barbour, M. Mohiuddin, C. Todhunter, J. Mansfield, T. Ahmad, Fraser Cummings, D. Jewell, J. Webster, Morris Brown, G. Lathrop, J. Connell, A. Dominiczak, C. Marcano, B. Burke, R. Dobson, J. Gungadoo, Kate Lee, P. Munroe, S. Newhouse, Abiodun Onipinla, C. Wallace, M. Xue, M. Caulfield, M. Farrall, A. Barton, I. Bruce, Hannah Donovan, S. Eyre, Paul Gilbert, S. Hider, A. Hinks, S. John, C. Potter, A. Silman, D. Symmons, W. Thomson, Jane Worthington, D. Dunger, B. Widmer, T. Frayling, R. Freathy, H. Lango, J. Perry, B. Shields, M. Weedon, A. Hattersley, G. Hitman, M. Walker, K. Elliott, C. Groves, C. Lindgren, N. Rayner, N. Timpson, E. Zeggini, M. Newport, G. Sirugo, Emily Lyons, F. Vannberg, A. Hill, L. Bradbury, C. Farrar, J. Pointon, Paul Wordsworth, M. Brown, J. Franklyn, J. Heward, M. Simmonds, S. Gough, S. Seal, M. Stratton, N. Rahman, M. Ban, A. Goris, S. Sawcer, Alastair Compston, D. Conway, M. Jallow, K. Rockett, S. Bumpstead, Amy Chaney, K. Downes, Mohammed Ghori, R. Gwilliam, S. Hunt, M. Inouye, A. Keniry, E. King, R. McGinnis, Simon Potter, R. Ravindrarajah, P. Whittaker, Claire Widden, D. Withers, Niall Cardin, T. Ferreira, Joanne Pereira-Gale, Ingileif Hallgrímsdóttir, Bryan Howie, Z. Su, Y. Teo, Damjan Vukcevic, D. Bentley, A. Compston (2007)
Genome-wide association study of 14,000 cases of seven common diseases and 3,000 shared controls
Nature, 447
Enda Byrne, P. Gehrman, S. Medland, D. Nyholt, A. Heath, P. Madden, I. Hickie, C. Duijn, A. Henders, G. Montgomery, N. Martin, N. Wray (2013)
A genome‐wide association study of sleep habits and insomnia
American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 162
Y. Wing, Jihui Zhang, S. Lam, Shirley Li, N. Tang, K. Lai, A. Li (2012)
Familial aggregation and heritability of insomnia in a community-based study.
Sleep medicine, 13 8
E. Bixler, A. Vgontzas, Hung-Mo Lin, S. Calhoun, A. Vela‐bueno, A. Kales (2005)
Excessive daytime sleepiness in a general population sample: the role of sleep apnea, age, obesity, diabetes, and depression.
The Journal of clinical endocrinology and metabolism, 90 8
S. Taheri, E. Mignot (2002)
The genetics of sleep disorders
The Lancet Neurology, 1
A. Nedeltcheva, F. Scheer (2014)
Metabolic effects of sleep disruption, links to obesity and diabetes
Current Opinion in Endocrinology & Diabetes and Obesity, 21
J. Marchini, Bryan Howie, S. Myers, G. McVean, P. Donnelly (2007)
A new multipoint method for genome-wide association studies by imputation of genotypes
Nature Genetics, 39
K. Oh‐hashi, Y. Naruse, F. Amaya, G. Shimosato, Masaki Tanaka (2003)
Cloning and Characterization of a Novel GRP78-binding Protein in the Rat Brain*
The Journal of Biological Chemistry, 278
(2005)
the role of sleep 636 apnea, age, obesity, diabetes, and depression
B. Bulik-Sullivan, H. Finucane, V. Anttila, A. Gusev, F. Day, Po-Ru Loh, L. Duncan, J. Perry, N. Patterson, E. Robinson, M. Daly, A. Price, B. Neale (2015)
An Atlas of Genetic Correlations across Human Diseases and Traits
Nature genetics, 47
Jared O'Connell, K. Sharp, N. Shrine, L. Wain, I. Hall, M. Tobin, J. Zagury, Olivier Delaneau, J. Marchini (2016)
Haplotype estimation for biobank scale datasets
Nature genetics, 48
F. Luyster, P. Strollo, P. Zee, J. Walsh (2012)
Sleep: a health imperative.
Sleep, 35 6
R. Rosenberg (2015)
Clinical assessment of excessive daytime sleepiness in the diagnosis of sleep disorders.
The Journal of clinical psychiatry, 76 12
S. Chouinard, J. Poulin, E. Stip, R. Godbout (2004)
Sleep in untreated patients with schizophrenia: a meta-analysis.
Schizophrenia bulletin, 30 4
J. Horwood (2014)
UK Biobank Data: Come and Get It
K. Farh, K. Farh, A. Marson, Jiang Zhu, Markus Kleinewietfeld, Markus Kleinewietfeld, Markus Kleinewietfeld, William Housley, Samantha Beik, N. Shoresh, Holly Whitton, Russell Ryan, Russell Ryan, Alexander Shishkin, Alexander Shishkin, Meital Hatan, M. Carrasco-Alfonso, Dita Mayer, C. Luckey, N. Patsopoulos, N. Patsopoulos, P. Jager, P. Jager, V. Kuchroo, C. Epstein, M. Daly, M. Daly, D. Hafler, D. Hafler, B. Bernstein (2014)
Genetic and Epigenetic Fine-Mapping of Causal Autoimmune Disease Variants
Nature, 518
Christopher Chang, C. Chow, L. Tellier, Shashaank Vattikuti, S. Purcell, James Lee (2014)
Second-generation PLINK: rising to the challenge of larger and richer datasets
GigaScience, 4
J. Dupuis, C. Langenberg, I. Prokopenko, R. Saxena, N. Soranzo, A. Jackson, E. Wheeler, N. Glazer, N. Bouatia-Naji, A. Gloyn, C. Lindgren, R. Mägi, A. Morris, J. Randall, T. Johnson, P. Elliott, Denis Rybin, G. Thorleifsson, V. Steinthorsdottir, P. Henneman, H. Grallert, A. Dehghan, J. Hottenga, C. Franklin, P. Navarro, Kijoung Song, A. Goel, J. Perry, J. Egan, T. Lajunen, N. Grarup, T. Sparsø, A. Doney, B. Voight, H. Stringham, Man Li, S. Kanoni, P. Shrader, Christine Cavalcanti-Proença, M. Kumari, L. Qi, N. Timpson, C. Gieger, C. Zabena, G. Rocheleau, E. Ingelsson, P. An, J. O’Connell, J. Luan, A. Elliott, S. Mccarroll, F. Payne, R. Roccasecca, F. Pattou, P. Sethupathy, K. Ardlie, Y. Ariyurek, B. Balkau, P. Barter, J. Beilby, Y. Ben-Shlomo, R. Benediktsson, A. Bennett, S. Bergmann, M. Bochud, E. Boerwinkle, A. Bonnefond, L. Bonnycastle, K. Borch-Johnsen, Y. Böttcher, E. Brunner, S. Bumpstead, G. Charpentier, Y. Chen, P. Chines, R. Clarke, L. Coin, M. Cooper, M. Cornelis, Gabriel Crawford, L. Crisponi, I. Day, E. Geus, J. Delplanque, C. Dina, M. Erdos, A. Fedson, A. Fischer-Rosinský, N. Forouhi, C. Fox, R. Frants, M. Franzosi, P. Galan, M. Goodarzi, J. Graessler, C. Groves, S. Grundy, R. Gwilliam, U. Gyllensten, S. Hadjadj, G. Hallmans, Naomi Hammond, Xijing Han, A. Hartikainen, N. Hassanali, C. Hayward, S. Heath, S. Hercberg, C. Herder, A. Hicks, D. Hillman, A. Hingorani, A. Hofman, J. Hui, J. Hung, B. Isomaa, P. Johnson, T. Jørgensen, A. Jula, M. Kaakinen, J. Kaprio, Y. Kesaniemi, M. Kivimaki, B. Knight, S. Koskinen, P. Kovacs, K. Kyvik, G. Lathrop, D. Lawlor, O. Bacquer, C. Lecoeur, Yun Li, V. Lyssenko, R. Mahley, M. Mangino, A. Manning, M. Martínez-Larrad, J. Mcateer, L. McCulloch, R. McPherson, C. Meisinger, D. Melzer, D. Meyre, B. Mitchell, M. Morken, S. Mukherjee, S. Naitza, Narisu Narisu, M. Neville, B. Oostra, M. Orrù, R. Pakyz, C. Palmer, G. Paolisso, C. Pattaro, Daniel Pearson, J. Peden, N. Pedersen, M. Perola, A. Pfeiffer, I. Pichler, O. Polašek, D. Posthuma, Simon Potter, A. Pouta, M. Province, B. Psaty, W. Rathmann, N. Rayner, K. Rice, S. Ripatti, F. Rivadeneira, M. Roden, O. Rolandsson, A. Sandbaek, M. Sandhu, S. Sanna, A. Sayer, P. Scheet, L. Scott, U. Seedorf, S. Sharp, B. Shields, G. Sigurðsson, E. Sijbrands, A. Silveira, Laila Simpson, A. Singleton, N. Smith, U. Sovio, A. Swift, H. Syddall, A. Syvänen, Toshiko Tanaka, B. Thorand, J. Tichet, A. Tönjes, T. Tuomi, A. Uitterlinden, K. Dijk, M. Hoek, Dhiraj Varma, S. Visvikis-Siest, V. Vitart, N. Vogelzangs, G. Waeber, Peter Wagner, A. Walley, G. Walters, K. Ward, H. Watkins, M. Weedon, S. Wild, G. Willemsen, J. Witteman, J. Yarnell, E. Zeggini, D. Zélénika, B. Zethelius, G. Zhai, J. Zhao, M. Zillikens, I. Borecki, R. Loos, P. Meneton, P. Magnusson, D. Nathan, G. Williams, A. Hattersley, K. Silander, V. Salomaa, G. Smith, S. Bornstein, P. Schwarz, J. Spranger, F. Karpe, A. Shuldiner, C. Cooper, G. Dedoussis, M. Serrano-Ríos, A. Morris, L. Lind, L. Palmer, F. Hu, P. Franks, S. Ebrahim, M. Marmot, W. Kao, J. Pankow, M. Sampson, J. Kuusisto, M. Laakso, T. Hansen, O. Pedersen, P. Pramstaller, H. Wichmann, T. Illig, I. Rudan, A. Wright, M. Stumvoll, H. Campbell, James Wilson, A. Hamsten, R. Bergman, T. Buchanan, F. Collins, K. Mohlke, J. Tuomilehto, T. Valle, D. Altshuler, J. Rotter, D. Siscovick, B. Penninx, D. Boomsma, P. Deloukas, T. Spector, T. Frayling, L. Ferrucci, A. Kong, U. Thorsteinsdóttir, K. Stefánsson, C. Duijn, Y. Aulchenko, A. Cao, A. Scuteri, D. Schlessinger, M. Uda, A. Ruokonen, M. Jarvelin, D. Waterworth, P. Vollenweider, L. Peltonen, V. Mooser, G. Abecasis, N. Wareham, R. Sladek, P. Froguel, R. Watanabe, J. Meigs, L. Groop, M. Boehnke, M. McCarthy, J. Florez, I. Barroso (2010)
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Nature genetics, 42
A. Ananthakrishnan, H. Khalili, G. Konijeti, L. Higuchi, P. Silva, C. Fuchs, J. Richter, E. Schernhammer, A. Chan (2014)
Sleep duration affects risk for ulcerative colitis: a prospective cohort study.
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association, 12 11
H. Gonnissen, T. Adam, R. Hursel, F. Rutters, S. Verhoef, M. Westerterp-Plantenga (2013)
Sleep duration, sleep quality and body weight: Parallel developments
Physiology & Behavior, 121
E. Kurant, C. Pai, R. Sharf, N. Halachmi, Y. Sun, A. Salzberg (1998)
Dorsotonals/homothorax, the Drosophila homologue of meis1, interacts with extradenticle in patterning of the embryonic PNS.
Development, 125 6
K. Takahama, J. Tomita, T. Ueno, Masako Yamazaki, S. Kume, K. Kume (2012)
Pan-neuronal knockdown of the c-Jun N-terminal Kinase (JNK) results in a reduction in sleep and longevity in Drosophila.
Biochemical and biophysical research communications, 417 2
Rachel Pemberton, Matthew Tyszkiewicz (2016)
Factors contributing to depressive mood states in everyday life: A systematic review.
Journal of affective disorders, 200
D. Gottlieb, George Connor, J. Wilk, T. 'connor
Bmc Medical Genetics Genome-wide Association of Sleep and Circadian Phenotypes
B. Cade, D. Gottlieb, D. Lauderdale, D. Bennett, A. Buchman, Sarah Buxbaum, P. Jager, Daniel Evans, T. Fülöp, S. Gharib, W. Johnson, H. Kim, E. Larkin, S. Lee, A. Lim, N. Punjabi, C. Shin, K. Stone, G. Tranah, Jia Weng, K. Yaffe, P. Zee, S. Patel, Xiaofeng Zhu, S. Redline, R. Saxena, R. Saxena (2016)
Common variants in DRD2 are associated with sleep duration: the CARe consortium.
Human molecular genetics, 25 1
Derek Spieler, Maria Kaffe, Franziska Knauf, José Bessa, J. Tena, F. Giesert, B. Schormair, E. Tilch, Heekyoung Lee, M. Horsch, D. Czamara, Nazanin Karbalai, Christine Toerne, M. Waldenberger, C. Gieger, P. Lichtner, M. Claussnitzer, R. Naumann, B. Müller-Myhsok, M. Torres, L. Garrett, J. Rozman, M. Klingenspor, V. Gailus-Durner, H. Fuchs, M. Angelis, J. Beckers, S. Hölter, T. Meitinger, S. Hauck, H. Laumen, W. Wurst, F. Casares, J. Gómez-Skarmeta, J. Winkelmann (2014)
Restless Legs Syndrome-associated intronic common variant in Meis1 alters enhancer function in the developing telencephalon
Genome Research, 24
Ying He, Christopher Jones, N. Fujiki, Ying Xu, Bin Guo, J. Holder, M. Rossner, S. Nishino, Ying-Hui Fu (2009)
The Transcriptional Repressor DEC2 Regulates Sleep Length in Mammals
Science, 325
Jing Wang, Dexter Duncan, Zhiao Shi, Bing Zhang (2013)
WEB-based GEne SeT AnaLysis Toolkit (WebGestalt): update 2013
Nucleic Acids Research, 41
R. Collins (2012)
What makes UK Biobank special?
The Lancet, 379
Daniel Evans, S. Snitker, Shi-Hsuan Wu, Aaloke Mody, O. Njajou, M. Perlis, P. Gehrman, A. Shuldiner, W. Hsueh (2011)
Habitual sleep/wake patterns in the Old Order Amish: heritability and association with non-genetic factors.
Sleep, 34 5
G. Poelmans, J. Buitelaar, D. Pauls, B. Franke (2011)
A theoretical molecular network for dyslexia: integrating available genetic findings
Molecular Psychiatry, 16
A. Heath, K. Kendler, L. Eaves, N. Martin (1990)
Evidence for genetic influences on sleep disturbance and sleep pattern in twins.
Sleep, 13 4
PR Loh (2015)
Efficient Bayesian mixed-model analysis increases association power in large cohorts
Nat. Genet., 47
C. Bécamel, Sophie Gavarini, B. Chanrion, G. Alonso, Nathalie Galéotti, A. Dumuis, J. Bockaert, P. Marin (2004)
The Serotonin 5-HT2A and 5-HT2C Receptors Interact with Specific Sets of PDZ Proteins*
Journal of Biological Chemistry, 279
J. Bradfield, H. Qu, Kai Wang, Haitao Zhang, P. Sleiman, Cecilia Kim, F. Mentch, H. Qiu, J. Glessner, Kelly Thomas, E. Frackelton, R. Chiavacci, M. Imieliński, D. Monos, R. Pandey, M. Bakay, S. Grant, C. Polychronakos, H. Hakonarson (2011)
A Genome-Wide Meta-Analysis of Six Type 1 Diabetes Cohorts Identifies Multiple Associated Loci
PLoS Genetics, 7
A. Heath, L. Eaves, Katherine Kirk, N. Martin (1998)
Effects of lifestyle, personality, symptoms of anxiety and depression, and genetic predisposition on subjective sleep disturbance and sleep pattern
Twin Research, 1
J. Swanson (2012)
The UK Biobank and selection bias
The Lancet, 380
C. Sudlow, J. Gallacher, N. Allen, V. Beral, P. Burton, J. Danesh, P. Downey, P. Elliott, J. Green, M. Landray, Bette Liu, P. Matthews, G. Ong, J. Pell, A. Silman, A. Young, Tim Sprosen, T. Peakman, R. Collins (2015)
UK Biobank: An Open Access Resource for Identifying the Causes of a Wide Range of Complex Diseases of Middle and Old Age
PLoS Medicine, 12
P. Sklar, J. Smoller, J. Fan, M. Ferreira, R. Perlis, K. Chambert, V. Nimgaonkar, M. McQueen, S. Faraone, A. Kirby, P. Bakker, M. Ogdie, M. Thase, G. Sachs, K. Todd-Brown, S. Gabriel, C. Sougnez, C. Gates, B. Blumenstiel, M. Defelice, K. Ardlie, J. Franklin, W. Muir, K. McGhee, D. Macintyre, A. McLean, M. VanBeck, A. McQuillin, N. Bass, M. Robinson, J. Lawrence, A. Anjorin, D. Curtis, E. Scolnick, M. Daly, D. Blackwood, H. Gurling, S. Purcell (2008)
Whole-genome association study of bipolar disorder
Molecular Psychiatry, 13
Samuel Jones, J. Tyrrell, A. Wood, R. Beaumont, K. Ruth, M. Tuke, H. Yaghootkar, Youna Hu, M. Teder-Laving, C. Hayward, T. Roenneberg, James Wilson, Fabiola Greco, A. Hicks, C. Shin, C. Yun, S. Lee, A. Metspalu, Enda Byrne, P. Gehrman, H. Tiemeier, K. Allebrandt, R. Freathy, A. Murray, D. Hinds, T. Frayling, M. Weedon (2016)
Genome-Wide Association Analyses in 128,266 Individuals Identifies New Morningness and Sleep Duration Loci
PLoS Genetics, 12
A. Erhardt, N. Akula, J. Schumacher, D. Czamara, Nazanin Karbalai, B. Müller-Myhsok, O. Mors, A. Børglum, A. Kristensen, D. Woldbye, P. Koefoed, E. Eriksson, E. Maron, E. Maron, A. Metspalu, A. Metspalu, J. Nurnberger, R. Philibert, J. Kennedy, K. Domschke, A. Reif, J. Deckert, Takeshi Otowa, Yukiko Kawamura, H. Kaiya, Y. Okazaki, H. Tanii, K. Tokunaga, Tsukasa Sasaki, J. Ioannidis, F. McMahon, E. Binder (2012)
Replication and meta-analysis of TMEM132D gene variants in panic disorder
Translational Psychiatry, 2
Fergal Connolly, D. Byrne, S. Lydon, C. Walsh, P. O’Connor (2017)
Barriers and facilitators related to the implementation of a physiological track and trigger system: A systematic review of the qualitative evidence
International Journal for Quality in Health Care, 29
J. Castro (2002)
The influence of heredity on self-reported sleep patterns in free-living humans.
Physiology & behavior, 76 4-5
E. Mignot (2004)
Sleep, sleep disorders and hypocretin (orexin).
Sleep medicine, 5 Suppl 1
RP Allen, PB Barker, A Horská, CJ Earley (2013)
Thalamic glutamate/glutamine in restless legs syndrome: increased and related to disturbed sleep
Neurology, 80
B. Shieh, B. Niemeyer (1995)
A novel protein encoded by the inad gene regulates recovery of visual transduction in drosophila
Neuron, 14
J. Lane, Irma Vlasac, S. Anderson, S. Kyle, W. Dixon, D. Bechtold, S. Gill, Max Little, A. Luik, A. Loudon, R. Emsley, F. Scheer, D. Lawlor, S. Redline, D. Ray, M. Rutter, R. Saxena (2016)
Genome-wide association analysis identifies novel loci for chronotype in 100,420 individuals from the UK Biobank
Nature Communications, 7
A. Hattersley, J. Tooke (1999)
The fetal insulin hypothesis: an alternative explanation of the association of low bir thweight with diabetes and vascular disease
The Lancet, 353
PR Gehrman, BT Keenan, EM Byrne, AI Pack (2015)
Genetics of sleep disorders
Psychiatr. Clin. North Am., 38
DJ Gottlieb, GT O'Connor, JB Wilk (2007)
Genome-wide association of sleep and circadian phenotypes
BMC Med. Genet., 8
K. Han, Seung-Il Choi, Tae-im Kim, Yong-Sun Maeng, R. Stulting, Yong Ji, Eung Kim (2016)
Pathogenesis and treatments of TGFBI corneal dystrophies
Progress in Retinal and Eye Research, 50
(2004)
a 622 meta-analysis
J. Winkelmann, D. Czamara, B. Schormair, Franziska Knauf, E. Schulte, C. Trenkwalder, Y. Dauvilliers, O. Polo, B. Högl, K. Berger, A. Fuhs, Nadine Gross, K. Stiasny‐Kolster, W. Oertel, C. Bachmann, W. Paulus, L. Xiong, J. Montplaisir, G. Rouleau, I. Fietze, J. Vâvrovâ, D. Kemlink, K. Šonka, S. Nevšímalová, Siong‐chi Lin, Z. Wszolek, C. Vilariño-Güell, M. Farrer, V. Gschliesser, B. Frauscher, T. Falkenstetter, W. Poewe, R. Allen, C. Earley, W. Ondo, W. Le, Derek Spieler, Maria Kaffe, A. Zimprich, J. Kettunen, M. Perola, K. Silander, I. Cournu-Rebeix, M. Francavilla, Claire Fontenille, B. Fontaine, P. Vodicka, H. Prokisch, P. Lichtner, P. Peppard, J. Faraco, E. Mignot, C. Gieger, T. Illig, H. Wichmann, B. Müller-Myhsok, T. Meitinger (2011)
Genome-Wide Association Study Identifies Novel Restless Legs Syndrome Susceptibility Loci on 2p14 and 16q12.1
PLoS Genetics, 7
B. Han, Hongyu Luo, J. Raelson, Jie Huang, Yun Li, J. Tremblay, Bing Hu, S. Qi, Jiangping Wu (2014)
TGFBI (βIG-H3) is a diabetes-risk gene based on mouse and human genetic studies.
Human molecular genetics, 23 17
M. Thompson, H. Xhaard, T. Sakurai, I. Rainero, J. Kukkonen (2014)
OX1 and OX2 orexin/hypocretin receptor pharmacogenetics
Frontiers in Neuroscience, 8
P. Foral, J. Knezevich, N. Dewan, M. Malesker (2011)
Medication-induced sleep disturbances.
The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists, 26 6
Po-Ru Loh, George Tucker, B. Bulik-Sullivan, B. Vilhjálmsson, H. Finucane, R. Salem, D. Chasman, P. Ridker, B. Neale, B. Berger, N. Patterson, A. Price (2014)
Supplementary Information for “Efficient Bayesian mixed model analysis increases association power in large cohorts”
(2014)
come and get 642 it
A. Sharpley, J. Elliott, M. Attenburrow, P. Cowen (1994)
Slow wave sleep in humans: Role of 5-HT2A and 5-HT2C receptors
Neuropharmacology, 33
N. Allen, C. Sudlow, T. Peakman, R. Collins (2014)
UK Biobank Data: Come and Get It
Science Translational Medicine, 6
L. Xiong, H. Catoire, P. Dion, C. Gaspar, R. Lafreniére, S. Girard, A. Levchenko, J. Rivière, L. Fiori, J. St‐Onge, I. Bachand, Pascale Thibodeau, R. Allen, C. Earley, G. Turecki, J. Montplaisir, G. Rouleau (2009)
MEIS1 intronic risk haplotype associated with restless legs syndrome affects its mRNA and protein expression levels.
Human molecular genetics, 18 6
J. Dalal, J. Roh, S. Maloney, A. Akuffo, Samir Shah, Han Yuan, Brie Wamsley, Wendell Jones, C. Strong, P. Gray, D. Holtzman, N. Heintz, J. Dougherty (2013)
Translational profiling of hypocretin neurons identifies candidate molecules for sleep regulation.
Genes & development, 27 5
R. Allen, P. Barker, A. Horská, C. Earley (2013)
Thalamic glutamate/glutamine in restless legs syndrome
Neurology, 80
H. Finucane, B. Bulik-Sullivan, A. Gusev, G. Trynka, Yakir Reshef, Po-Ru Loh, V. Anttila, Han Xu, C. Zang, K. Farh, S. Ripke, F. Day, S. Purcell, E. Stahl, S. Lindstrom, J. Perry, Y. Okada, S. Raychaudhuri, M. Daly, N. Patterson, B. Neale, A. Price (2015)
Partitioning heritability by functional annotation using genome-wide association summary statistics
Nature genetics, 47
P. Franken, M. Tafti (2003)
Genetics of sleep and sleep disorders.
Frontiers in bioscience : a journal and virtual library, 8
L. Ward, Manolis Kellis (2015)
HaploReg v4: systematic mining of putative causal variants, cell types, regulators and target genes for human complex traits and disease
Nucleic Acids Research, 44
K. Allebrandt, N. Amin, B. Mueller-Myhsok, T. Esko, M. Teder-Laving, R. Azevedo, C. Hayward, J. Mill, N. Vogelzangs, E. Green, Scott Melville, P. Lichtner, H. Wichmann, B. Oostra, A. Janssens, H. Campbell, James Wilson, A. Hicks, P. Pramstaller, Z. Dogas, I. Rudan, I. Rudan, M. Merrow, B. Penninx, C. Kyriacou, A. Metspalu, C. Duijn, T. Meitinger, T. Roenneberg (2011)
A KATP channel gene effect on sleep duration: from genome-wide association studies to function in Drosophila
Molecular Psychiatry, 18
A. Vgontzas, Edward Bixler, T. Tan, Deborah Kantner, Louis Martin, A. Kales (1998)
Obesity without sleep apnea is associated with daytime sleepiness.
Archives of internal medicine, 158 12
M. Partinen, tJaakko Kaprio, tMarkku Koskenvuo, P. Putkonen, H. Langinvainio (1983)
Genetic and environmental determination of human sleep.
Sleep, 6 3
(2015)
the CHARGE Consortium 499 Genome-Wide Association Study
A. Locke, Bratati Kahali, S. Berndt, A. Justice, T. Pers, F. Day, Corey Powell, S. Vedantam, Martin Buchkovich, Jian Yang, Damien Croteau-Chonka, T. Esko, T. Fall, T. Ferreira, S. Gustafsson, Z. Kutalik, J. Luan, R. Mägi, J. Randall, T. Winkler, A. Wood, T. Workalemahu, J. Faul, Jennifer Smith, J. Zhao, Wei Zhao, Jin Chen, R. Fehrmann, Å. Hedman, J. Karjalainen, Ellen Schmidt, D. Absher, N. Amin, Denise Anderson, M. Beekman, J. Bolton, J. Bragg-Gresham, S. Buyske, A. Demirkan, Guohong Deng, G. Ehret, B. Feenstra, M. Feitosa, K. Fischer, A. Goel, Jian Gong, A. Jackson, S. Kanoni, M. Kleber, K. Kristiansson, U. Lim, Vaneet Lotay, M. Mangino, I. Leach, C. Medina-Gomez, S. Medland, M. Nalls, Cameron Palmer, D. Pasko, S. Pechlivanis, M. Peters, I. Prokopenko, D. Shungin, A. Stančáková, R. Strawbridge, Y. Sung, Toshiko Tanaka, A. Teumer, S. Trompet, S. Laan, J. Setten, J. Vliet-Ostaptchouk, Zhaoming Wang, L. Yengo, Weihua Zhang, A. Isaacs, E. Albrecht, J. Ärnlöv, Gillian Arscott, A. Attwood, S. Bandinelli, Amy Barrett, Isabelita Bas, C. Bellis, A. Bennett, C. Berne, R. Blagieva, M. Blüher, S. Böhringer, L. Bonnycastle, Y. Böttcher, H. Boyd, M. Bruinenberg, I. Caspersen, Y. Chen, R. Clarke, E. Daw, A. Craen, G. Delgado, M. Dimitriou, A. Doney, N. Eklund, K. Estrada, Elodie Eury, L. Folkersen, Ross Fraser, M. Garcia, F. Geller, V. Giedraitis, B. Gigante, A. Go, A. Golay, A. Goodall, S. Gordon, Mathias Gorski, H. Grabe, H. Grallert, T. Grammer, J. Grässler, H. Grönberg, C. Groves, G. Gusto, J. Haessler, P. Hall, T. Haller, G. Hallmans, C. Hartman, M. Hassinen, C. Hayward, N. Heard-Costa, Q. Helmer, C. Hengstenberg, O. Holmen, J. Hottenga, A. James, J. Jeff, Å. Johansson, J. Jolley, Thorhildur Juliusdottir, L. Kinnunen, W. Koenig, M. Koskenvuo, W. Kratzer, J. Laitinen, C. Lamina, K. Leander, N. Lee, P. Lichtner, L. Lind, J. Lindström, K. Lo, S. Lobbens, R. Lorbeer, Yingchang Lu, F. Mach, P. Magnusson, A. Mahajan, W. McArdle, S. McLachlan, C. Menni, S. Merger, E. Mihailov, L. Milani, A. Moayyeri, K. Monda, M. Morken, A. Mulas, G. Müller, M. Müller-Nurasyid, A. Musk, R. Nagaraja, M. Nöthen, I. Nolte, S. Pilz, N. Rayner, Frida Renstrom, R. Rettig, J. Ried, S. Ripke, N. Robertson, L. Rose, S. Sanna, H. Scharnagl, S. Scholtens, F. Schumacher, W. Scott, T. Seufferlein, Jianxin Shi, A. Smith, Joanna Smolonska, A. Stanton, V. Steinthorsdottir, K. Stirrups, H. Stringham, J. Sundström, M. Swertz, A. Swift, A. Syvänen, S. Tan, B. Tayo, B. Thorand, G. Thorleifsson, J. Tyrer, H. Uh, L. Vandenput, F. Verhulst, S. Vermeulen, N. Verweij, J. Vonk, L. Waite, H. Warren, D. Waterworth, M. Weedon, L. Wilkens, C. Willenborg, T. Wilsgaard, M. Wojczynski, A. Wong, A. Wright, Qunyuan Zhang, E. Brennan, Murim Choi, Z. Dastani, A. Drong, P. Eriksson, A. Franco-Cereceda, J. Gådin, A. Gharavi, M. Goddard, R. Handsaker, Jinyan Huang, F. Karpe, S. Kathiresan, S. Keildson, K. Kiryluk, M. Kubo, Jong-Young Lee, L. Liang, R. Lifton, Baoshan Ma, S. Mccarroll, A. McKnight, J. Min, M. Moffatt, G. Montgomery, J. Murabito, G. Nicholson, D. Nyholt, Y. Okada, J. Perry, R. Dorajoo, E. Reinmaa, R. Salem, N. Sandholm, R. Scott, L. Stolk, A. Takahashi, Toshihiro Tanaka, F. Hooft, Anna Vinkhuyzen, H. Westra, W. Zheng, K. Zondervan, A. Heath, D. Arveiler, S. Bakker, J. Beilby, R. Bergman, J. Blangero, P. Bovet, H. Campbell, M. Caulfield, G. Cesana, A. Chakravarti, D. Chasman, P. Chines, F. Collins, D. Crawford, L. Cupples, D. Cusi, J. Danesh, U. Faire, H. Ruijter, A. Dominiczak, R. Erbel, J. Erdmann, J. Eriksson, M. Farrall, S. Felix, E. Ferrannini, J. Ferrières, I. Ford, N. Forouhi, T. Forrester, O. Franco, R. Gansevoort, P. Gejman, C. Gieger, O. Gottesman, V. Gudnason, U. Gyllensten, A. Hall, T. Harris, A. Hattersley, A. Hicks, L. Hindorff, A. Hingorani, A. Hofman, G. Homuth, G. Hovingh, S. Humphries, S. Hunt, E. Hyppönen, T. Illig, K. Jacobs, M. Jarvelin, K. Jöckel, B. Johansen, P. Jousilahti, J. Jukema, A. Jula, J. Kaprio, J. Kastelein, S. Keinanen-Kiukaanniemi, L. Kiemeney, P. Knekt, J. Kooner, C. Kooperberg, P. Kovacs, A. Kraja, M. Kumari, J. Kuusisto, T. Lakka, C. Langenberg, L. Marchand, T. Lehtimäki, V. Lyssenko, S. Männistö, A. Marette, T. Matise, C. McKenzie, B. McKnight, F. Moll, A. Morris, A. Morris, J. Murray, M. Nelis, C. Ohlsson, A. Oldehinkel, K. Ong, P. Madden, G. Pasterkamp, J. Peden, A. Peters, D. Postma, P. Pramstaller, J. Price, L. Qi, O. Raitakari, T. Rankinen, D. Rao, T. Rice, P. Ridker, J. Rioux, M. Ritchie, I. Rudan, V. Salomaa, N. Samani, J. Saramies, M. Sarzynski, H. Schunkert, P. Schwarz, P. Sever, A. Shuldiner, J. Sinisalo, R. Stolk, K. Strauch, A. Tönjes, D. Trégouët, A. Tremblay, E. Tremoli, J. Virtamo, M. Vohl, U. Völker, G. Waeber, G. Willemsen, J. Witteman, M. Zillikens, L. Adair, P. Amouyel, F. Asselbergs, T. Assimes, M. Bochud, B. Boehm, E. Boerwinkle, S. Bornstein, E. Bottinger, C. Bouchard, S. Cauchi, J. Chambers, S. Chanock, R. Cooper, P. Bakker, G. Dedoussis, L. Ferrucci, P. Franks, P. Froguel, L. Groop, C. Haiman, A. Hamsten, J. Hui, D. Hunter, K. Hveem, R. Kaplan, M. Kivimaki, D. Kuh, M. Laakso, Yongmei Liu, N. Martin, W. März, M. Melbye, A. Metspalu, S. Moebus, P. Munroe, I. Njølstad, B. Oostra, C. Palmer, N. Pedersen, M. Perola, L. Pérusse, U. Peters, C. Power, T. Quertermous, R. Rauramaa, F. Rivadeneira, T. Saaristo, D. Saleheen, N. Sattar, E. Schadt, D. Schlessinger, P. Slagboom, H. Snieder, T. Spector, U. Thorsteinsdóttir, M. Stumvoll, J. Tuomilehto, A. Uitterlinden, M. Uusitupa, P. Harst, M. Walker, H. Wallaschofski, N. Wareham, H. Watkins, D. Weir, H. Wichmann, James Wilson, P. Zanen, I. Borecki, P. Deloukas, C. Fox, I. Heid, J. O’Connell, D. Strachan, K. Stefánsson, C. Duijn, G. Abecasis, L. Franke, T. Frayling, M. McCarthy, P. Visscher, A. Scherag, C. Willer, M. Boehnke, K. Mohlke, C. Lindgren, J. Beckmann, I. Barroso, K. North, E. Ingelsson, J. Hirschhorn, R. Loos, Elizabeth Speliotes (2015)
Genetic studies of body mass index yield new insights for obesity biology
Nature, 518
F. Hamdan, H. Daoud, D. Rochefort, A. Piton, J. Gauthier, Mathieu Langlois, Gila Foomani, Sylvia Dobrzeniecka, M. Krebs, R. Joober, R. Lafreniére, J. Lacaille, L. Mottron, P. Drapeau, M. Beauchamp, M. Phillips, E. Fombonne, G. Rouleau, J. Michaud (2010)
De novo mutations in FOXP1 in cases with intellectual disability, autism, and language impairment.
American journal of human genetics, 87 5
Youna Hu, A. Shmygelska, D. Tran, N. Eriksson, J. Tung, D. Hinds (2016)
GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person
Nature Communications, 7
W. Herring, K. Connor, N. Ivgy-may, E. Snyder, Kenneth Liu, D. Snavely, A. Krystal, J. Walsh, R. Benca, R. Rosenberg, R. Sangal, Kerry Budd, J. Hutzelmann, H. Leibensperger, S. Froman, C. Lines, T. Roth, D. Michelson (2016)
Suvorexant in Patients With Insomnia: Results From Two 3-Month Randomized Controlled Clinical Trials
Biological Psychiatry, 79
T. Hisa, S. Spence, R. Rachel, Masami Fujita, Takuro Nakamura, J. Ward, Deborah Devor-Henneman, Y. Saiki, H. Kutsuna, L. Tessarollo, N. Jenkins, N. Copeland (2004)
Hematopoietic, angiogenic and eye defects in Meis1 mutant animals
The EMBO Journal, 23
Po-Ru Loh, P. Palamara, A. Price (2015)
Fast and accurate long-range phasing in a UK Biobank cohort
Nature genetics, 48
D. Gottlieb, K. Hek, Ting-hsu Chen, N. Watson, G. Eiriksdottir, Enda Byrne, M. Cornelis, S. Warby, S. Bandinelli, L. Cherkas, Daniel Evans, H. Grabe, J. Lahti, Man Li, T. Lehtimäki, T. Lumley, K. Marciante, L. Pérusse, B. Psaty, J. Robbins, G. Tranah, J. Vink, J. Wilk, J. Stafford, C. Bellis, R. Biffar, C. Bouchard, B. Cade, G. Curhan, J. Eriksson, R. Ewert, L. Ferrucci, T. Fülöp, P. Gehrman, Robert Goodloe, T. Harris, A. Heath, D. Hernandez, A. Hofman, J. Hottenga, D. Hunter, M. Jensen, Andrew Johnson, M. Kähönen, L. Kao, P. Kraft, E. Larkin, D. Lauderdale, A. Luik, M. Medici, G. Montgomery, A. Palotie, S. Patel, G. Pistis, E. Porcu, L. Quaye, O. Raitakari, S. Redline, E. Rimm, J. Rotter, A. Smith, T. Spector, A. Teumer, A. Uitterlinden, M. Vohl, E. Widén, G. Willemsen, T. Young, Xiaoling Zhang, Yongmei Liu, J. Blangero, D. Boomsma, V. Gudnason, F. Hu, M. Mangino, N. Martin, G. O'Connor, K. Stone, Toshiko Tanaka, J. Viikari, S. Gharib, N. Punjabi, K. Räikkönen, H. Völzke, E. Mignot, H. Tiemeier (2014)
Novel Loci Associated with Usual Sleep Duration: The CHARGE Consortium Genome-Wide Association Study
Molecular psychiatry, 20
Yuxin Fan, Elena Linardopoulou, C. Friedman, E. Williams, B. Trask (2002)
Genomic structure and evolution of the ancestral chromosome fusion site in 2q13-2q14.1 and paralogous regions on other human chromosomes.
Genome research, 12 11
M. Mackiewicz, K. Shockley, Micah Romer, R. Galante, J. Zimmerman, N. Naidoo, D. Baldwin, S. Jensen, G. Churchill, A. Pack (2007)
Macromolecule biosynthesis: a key function of sleep.
Physiological genomics, 31 3
Laura Yelin-Bekerman, Idan Elbaz, Alex Diber, Dvir Dahary, L. Gibbs-Bar, Shahar Alon, T. Lerer-Goldshtein, L. Appelbaum (2015)
Hypocretin neuron-specific transcriptome profiling identifies the sleep modulator Kcnh4a
eLife, 4
J. Winkelmann, B. Schormair, P. Lichtner, S. Ripke, L. Xiong, S. Jalilzadeh, S. Fulda, B. Pütz, G. Eckstein, S. Hauk, C. Trenkwalder, A. Zimprich, K. Stiasny‐Kolster, W. Oertel, C. Bachmann, W. Paulus, I. Peglau, I. Eisensehr, J. Montplaisir, G. Turecki, G. Rouleau, C. Gieger, T. Illig, H. Wichmann, F. Holsboer, B. Müller-Myhsok, T. Meitinger (2007)
Genome-wide association study of restless legs syndrome identifies common variants in three genomic regions
Nature Genetics, 39
B. Bulik-Sullivan, Po-Ru Loh, H. Finucane, S. Ripke, Jian Yang, N. Patterson, M. Daly, A. Price, B. Neale (2014)
LD Score regression distinguishes confounding from polygenicity in genome-wide association studies
Nature Genetics, 47
M. Horikoshi, H. Yaghootkar, Dennis Mook-Kanamori, D. Mook-Kanamori, U. Sovio, U. Sovio, H. Taal, B. Hennig, J. Bradfield, B. Pourcain, David Evans, P. Charoen, P. Charoen, M. Kaakinen, D. Cousminer, T. Lehtimäki, Eskil Kreiner-Møller, N. Warrington, M. Bustamante, B. Feenstra, D. Berry, E. Thiering, T. Pfab, T. Pfab, S. Barton, B. Shields, M. Kerkhof, E. Leeuwen, A. Fulford, Z. Kutalik, Z. Kutalik, Jinghua Zhao, M. Hoed, A. Mahajan, V. Lindi, Liang Goh, J. Hottenga, Ying Wu, O. Raitakari, M. Harder, A. Meirhaeghe, A. Meirhaeghe, A. Meirhaeghe, I. Ntalla, R. Salem, R. Salem, K. Jameson, K. Zhou, D. Monies, V. Lagou, M. Kirin, Jani Heikkinen, L. Adair, F. Alkuraya, A. Al-odaib, P. Amouyel, P. Amouyel, P. Amouyel, E. Andersson, A. Bennett, A. Blakemore, J. Buxton, Jean Dallongeville, Jean Dallongeville, Jean Dallongeville, Shikta Das, E. Geus, Xavier Estivill, Xavier Estivill, C. Flexeder, P. Froguel, P. Froguel, P. Froguel, F. Geller, K. Godfrey, F. Gottrand, C. Groves, T. Hansen, Torben Hansen, J. Hirschhorn, J. Hirschhorn, A. Hofman, M. Hollegaard, D. Hougaard, E. Hyppönen, H. Inskip, A. Isaacs, A. Isaacs, T. Jørgensen, C. Kanaka-Gantenbein, J. Kemp, W. Kiess, Tuomas Kilpeläinen, Tuomas Kilpeläinen, N. Klopp, B. Knight, C. Kuzawa, George Mcmahon, J. Newnham, H. Niinikoski, B. Oostra, L. Pedersen, D. Postma, S. Ring, F. Rivadeneira, N. Robertson, Sylvain Sebert, Sylvain Sebert, O. Simell, T. Slowinski, Carla Tiesler, A. Tönjes, Allan Vaag, Allan Vaag, J. Viikari, J. Vink, N. Vissing, N. Wareham, G. Willemsen, D. Witte, Haitao Zhang, Jianhua Zhao, James Wilson, M. Stumvoll, A. Prentice, B. Meyer, E. Pearson, C. Boreham, C. Cooper, M. Gillman, G. Dedoussis, L. Moreno, Oluf Pedersen, Oluf Pedersen, Oluf Pedersen, M. Saarinen, K. Mohlke, D. Boomsma, S. Saw, S. Saw, T. Lakka, A. Körner, R. Loos, K. Ong, P. Vollenweider, C. Duijn, G. Koppelman, A. Hattersley, J. Holloway, B. Hocher, J. Heinrich, C. Power, M. Melbye, M. Guxens, M. Guxens, C. Pennell, K. Bønnelykke, H. Bisgaard, J. Eriksson, E. Widén, H. Hakonarson, A. Uitterlinden, A. Pouta, A. Pouta, D. Lawlor, G. Smith, T. Frayling, M. McCarthy, Mark McCarthy, S. Grant, V. Jaddoe, M. Järvelin, N. Timpson, I. Prokopenko, R. Freathy, R. Freathy (2012)
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism
Nature genetics, 45

Publisher: Springer Journals
Subject: Biomedicine; Biomedicine, general; Human Genetics; Cancer Research; Agriculture; Gene Function; Animal Genetics and Genomics
ISSN: 1061-4036
eISSN: 1546-1718
DOI: 10.1038/ng.3749
Publisher site: See Article on Publisher Site

Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits

Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits

Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits

Genome-wide association analyses of sleep disturbance traits identify new loci and highlight shared genetics with neuropsychiatric and metabolic traits

References (105)

Abstract

Journal

Recommended Articles

There are no references for this article.

Our policy towards the use of cookies