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Cell Damage in the Brain: A Speculative Synthesis:

Cell Damage in the Brain: A Speculative Synthesis: Journal af Cerebral Blood FloH' and Metabolism 1:155-185 © 1981 Raven Press. New York Review Bo K. Siesjo Lahoratory (�f' Experimental Brain Research, University Hospital, Lund, SII'eden All cells in living org anisms have a limited life NEURONAL CELL DAMAGE IN THE BRAIN span, and when the time set by their biologica l clocks has run out, they will die, their highly orga­ Occurrence nized macro molec ular structu re will disintegrate, 1, Severe hypoxia, e,g., low Pao2 combined with some and the low-molec ular degradation products be­ reduction in cerebral perfusion pressure, 2, Severe ischemia with reduction in CBF to less than co me part of the disorder of the surroundings. In 50% of control, thermodyna mic terms, this series of events consti­ 3, Repeated or sustained epileptic seizures, tutes what has been ca lled the entropic doom. We 4, Severe hypoglycemia with loss of spontaneous or know little about those molec ular mecha nisms that evoked electrical activity. limit the life span of cells in the absence of disease. Localization For the clinicia n, therefore, the important task is to Cerebral cortex (pyramidal cells in layers 3 and 5 -6) pr event or treat diseases that jeopardize http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Cerebral Blood Flow & Metabolism SAGE

Cell Damage in the Brain: A Speculative Synthesis:

Siesjö, Bo K.
Journal of Cerebral Blood Flow & Metabolism , Volume 1 (2): 31 – Jun 29, 2016
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References (280)

Publisher
SAGE
Copyright
Copyright © 2022 by International Society for Cerebral Blood Flow and Metabolism
ISSN
0271-678X
eISSN
1559-7016
DOI
10.1038/jcbfm.1981.18
Publisher site
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Abstract

Journal af Cerebral Blood FloH' and Metabolism 1:155-185 © 1981 Raven Press. New York Review Bo K. Siesjo Lahoratory (�f' Experimental Brain Research, University Hospital, Lund, SII'eden All cells in living org anisms have a limited life NEURONAL CELL DAMAGE IN THE BRAIN span, and when the time set by their biologica l clocks has run out, they will die, their highly orga­ Occurrence nized macro molec ular structu re will disintegrate, 1, Severe hypoxia, e,g., low Pao2 combined with some and the low-molec ular degradation products be­ reduction in cerebral perfusion pressure, 2, Severe ischemia with reduction in CBF to less than co me part of the disorder of the surroundings. In 50% of control, thermodyna mic terms, this series of events consti­ 3, Repeated or sustained epileptic seizures, tutes what has been ca lled the entropic doom. We 4, Severe hypoglycemia with loss of spontaneous or know little about those molec ular mecha nisms that evoked electrical activity. limit the life span of cells in the absence of disease. Localization For the clinicia n, therefore, the important task is to Cerebral cortex (pyramidal cells in layers 3 and 5 -6) pr event or treat diseases that jeopardize

Journal

Journal of Cerebral Blood Flow & Metabolism – SAGE

Published: Jun 29, 2016

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