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- Publisher
- American Psychological Association
- Copyright
- Copyright © 1996 American Psychological Association
- ISSN
- 0012-1649
- eISSN
- 1939-0599
- DOI
- 10.1037/0012-1649.32.3.404
- Publisher site
- See Article on Publisher Site
Abstract
In human teratology, the magnitude of exposures cannot be experimentally controlled. But when dose and response are both measured redundantly, a new statistical approach, Partial Least Squares, can powerfully summarize the data while avoiding familiar inferential pitfalls. Procedures of this class have been exploited in a study of the enduring effects of prenatal alcohol exposure upon neurobehavioral development of some 500 children born in 1975–1976. In the context of that study, this article reviews the new methodology under 4 headings: (a) descriptions of dose and outcome measures jointly by way of new composite scores and their saliences (cross-correlations), (b) covariate adjustments for these summaries and scores, (c) methods for inspecting the dose–response relationship between the composites and the original measures, and (d) methods for studying the emergence or amelioration of deficits across developmental age.
Journal
Developmental Psychology – American Psychological Association
Published: May 1, 1996