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Cigarette Smoking and the Incidence of Cervical Intraepithelial Neoplasia, Grade III, and Cancer of the Cervix Uteri

Cigarette Smoking and the Incidence of Cervical Intraepithelial Neoplasia, Grade III, and Cancer... The relation between cigarette smoking and cervical intraepithelial neoplasia, grade III (CIN III), and cervical cancer was examined among a cohort of 6,812 women in Tromsö, Norway, between 1980 and 1989. During the 52,844 person-years of observation, 185 incident cases (177 women with CIN III and eight with cervical cancer) were recorded in the regional pathology registry. The age-adjusted incidence rates of CIN III and cervical cancer were 267/100,000 person-years among women who had never smoked, 183/100,000 person-years among exsmokers, and 476/100,000 person-years among current smokers. A multivariate model containing terms for age, marital status, and frequency of intoxication yielded a relative rate for current smokers compared with nonsmokers of 1.5 (95% confidence interval 1.0–2.2). Statistical trend tests for the number of cigarettes smoked per day (never, 1–14, and ≥15 cigarettes), years of smoking (never, 1–9, and ≥10 years), and age started smoking (<16, 16–18, 19–21, and ≥22 years) all yielded significant results. These findings support the opinion that CIN III and cervical cancer are a smoking-related disease. Am J Epidemiol 1992;135:341–6. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png American Journal of Epidemiology Oxford University Press

Cigarette Smoking and the Incidence of Cervical Intraepithelial Neoplasia, Grade III, and Cancer of the Cervix Uteri

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Publisher
Oxford University Press
Copyright
© Published by Oxford University Press.
ISSN
0002-9262
eISSN
1476-6256
DOI
10.1093/oxfordjournals.aje.a116295
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See Article on Publisher Site

Abstract

The relation between cigarette smoking and cervical intraepithelial neoplasia, grade III (CIN III), and cervical cancer was examined among a cohort of 6,812 women in Tromsö, Norway, between 1980 and 1989. During the 52,844 person-years of observation, 185 incident cases (177 women with CIN III and eight with cervical cancer) were recorded in the regional pathology registry. The age-adjusted incidence rates of CIN III and cervical cancer were 267/100,000 person-years among women who had never smoked, 183/100,000 person-years among exsmokers, and 476/100,000 person-years among current smokers. A multivariate model containing terms for age, marital status, and frequency of intoxication yielded a relative rate for current smokers compared with nonsmokers of 1.5 (95% confidence interval 1.0–2.2). Statistical trend tests for the number of cigarettes smoked per day (never, 1–14, and ≥15 cigarettes), years of smoking (never, 1–9, and ≥10 years), and age started smoking (<16, 16–18, 19–21, and ≥22 years) all yielded significant results. These findings support the opinion that CIN III and cervical cancer are a smoking-related disease. Am J Epidemiol 1992;135:341–6.

Journal

American Journal of Epidemiology – Oxford University Press

Published: Feb 15, 1992

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