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Assessment and Hormonal Treatment of the Luteal Phase of In Vitro Fertilization Cycles

Assessment and Hormonal Treatment of the Luteal Phase of In Vitro Fertilization Cycles Summary: Luteal phase lengths and hormonal profiles (progesterone, oestra‐diol‐17 beta, beta HCG and prolactin) have been documented in 77 cases derived from a series of patients undergoing IVF. Nineteen pregnancies were generated during this series and 12 healthy infants have already been delivered. Luteal phase lengths were 14.5pM 0.5 days with 14.3% demonstrating mid‐luteal progesterone levels of less than 31 nmols/1, considered to be low for successful conception. A random study of luteal support regimens comparing HCG or medroxyprogesterone acetate (MPA) with nil therapy was studied in a series of 44 consecutive embryo transfers during which 10 pregnancies were achieved. No difference was noted in the pregnancy rates for the 3 groups but the pregnancy outcome was better in those who had HCG support and this was more apparent in the overall series of 19 pregnancies. A significant luteotrophic effect was noted with HCG support regimens whilst MPA appeared to have a luteal suppressant action. Six pregnancies which aborted with blighted ova were derived from cycles in which the luteal phase progesterone levels were low raising the possibility that a poor hormonal environment may predispose to blighted ova. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Australian and New Zealand Journal of Obstetrics and Gynaecology Wiley

Assessment and Hormonal Treatment of the Luteal Phase of In Vitro Fertilization Cycles

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References (18)

Publisher
Wiley
Copyright
Copyright © 1984 Wiley Subscription Services, Inc., A Wiley Company
ISSN
0004-8666
eISSN
1479-828X
DOI
10.1111/j.1479-828X.1984.tb01472.x
Publisher site
See Article on Publisher Site

Abstract

Summary: Luteal phase lengths and hormonal profiles (progesterone, oestra‐diol‐17 beta, beta HCG and prolactin) have been documented in 77 cases derived from a series of patients undergoing IVF. Nineteen pregnancies were generated during this series and 12 healthy infants have already been delivered. Luteal phase lengths were 14.5pM 0.5 days with 14.3% demonstrating mid‐luteal progesterone levels of less than 31 nmols/1, considered to be low for successful conception. A random study of luteal support regimens comparing HCG or medroxyprogesterone acetate (MPA) with nil therapy was studied in a series of 44 consecutive embryo transfers during which 10 pregnancies were achieved. No difference was noted in the pregnancy rates for the 3 groups but the pregnancy outcome was better in those who had HCG support and this was more apparent in the overall series of 19 pregnancies. A significant luteotrophic effect was noted with HCG support regimens whilst MPA appeared to have a luteal suppressant action. Six pregnancies which aborted with blighted ova were derived from cycles in which the luteal phase progesterone levels were low raising the possibility that a poor hormonal environment may predispose to blighted ova.

Journal

Australian and New Zealand Journal of Obstetrics and Gynaecology – Wiley

Published: May 1, 1984

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