Access the full text.
Sign up today, get DeepDyve free for 14 days.
Loading next page...
/lp/springer-journals/somatic-generation-of-antibody-diversity-sCdo0pslJs
References (127)
-
R. Maki, W. Roeder, A. Traunecker, C. Sidman, M. Wabl, W. Raschke, S. Tonegawa (1981)
The role of DNA rearrangement and alternative RNA processing in the expression of immunoglobulin delta genesCell, 24
-
W. Dreyer, J. Bennett (1965)
The molecular basis of antibody formation: a paradox.Proceedings of the National Academy of Sciences of the United States of America, 54 3
-
W. Roeder, R. Maki, A. Traunecker, S. Tonegawa (1981)
Linkage of the four gamma subclass heavy chain genes.Proceedings of the National Academy of Sciences of the United States of America, 78 1
-
J. Höchtl, C. Müller, H. Zachau (1982)
Recombined flanks of the variable and joining segments of immunoglobulin genes.Proceedings of the National Academy of Sciences of the United States of America, 79 5
-
H. Sakano, R. Maki, Y. Kurosawa, W. Roeder, S. Tonegawa (1980)
Two types of somatic recombination are necessary for the generation of complete immunoglobulin heavy-chain genesNature, 286
-
M. Steinmetz, W. Altenburger, H. Zachau (1980)
A rearranged DNA sequence possibly related to the translocation of immunoglobulin gene segments.Nucleic acids research, 8 8
-
M. Potter (1971)
Antigen-binding myeloma proteins in mice.Annals of the New York Academy of Sciences, 190
-
R. Maki, A. Traunecker, H. Sakano, W. Roeder, S. Tonegawa (1980)
Exon shuffling generates an immunoglobulin heavy chain gene.Proceedings of the National Academy of Sciences of the United States of America, 77 4
-
A. Bothwell, M. Paskind, R. Schwartz, G. Sonenshein, M. Gefter, D. Baltimore (1981)
Dual expression of λ genes in the MOPC-315 plasmacytomaNature, 290
-
N. Gough, O. Bernard (1981)
Sequences of the joining region genes for immunoglobulin heavy chains and their role in generation of antibody diversity.Proceedings of the National Academy of Sciences of the United States of America, 78 1
-
D. Baltimore (1981)
Gene conversion: Some implications for immunoglobulin genesCell, 24
-
M. Burnet (1966)
A Possible Genetic Basis for Specific Pattern in AntibodyNature, 210
-
T. Méo, J. Johnson, C. Beechey, S. Andrews, J. Peters, A. Searle (1980)
Linkage analyses of murine immunoglobulin heavy chain and serum prealbumin genes establish their location on chromosome 12 proximal to the T (5;12) 31H breakpoint in band 12F1.Proceedings of the National Academy of Sciences of the United States of America, 77 1
-
N. Jerne (1971)
The somatic generation of immune recognitionEuropean Journal of Immunology, 1
-
E. Max, J. Seidman, H. Miller, P. Leder (1980)
Variation in the crossover point of kappa immunoglobulin gene V-J recombination: Evidence from a cryptic geneCell, 21
-
N. Hilschmann, L. Craig (1965)
Amino acid sequence studies with Bence-Jones proteins.Proceedings of the National Academy of Sciences of the United States of America, 53 6
-
R. Porter (1973)
Structural Studies of ImmunoglobulinsScandinavian Journal of Immunology, 34
-
F. Putnam, C. Easley (1965)
STRUCTURAL STUDIES OF THE IMMUNOGLOBULINS. I. THE TRYPTIC PEPTIDES OF BENCE-JONES PROTEINS.The Journal of biological chemistry, 240
-
P. Early, Henry Huang, Mark Davis, K. Calame, Leroy Hood (1980)
An immunoglobulin heavy chain variable region gene is generated from three segments of DNA: VH, D and JHCell, 19
-
M. Steward (1975)
Staphylococci and Staphylococcal Infections: Recent ProgressImmunology, 28
-
L. Hood, M. Davis, P. Early, K. Calame, S. Kim, S. Crews, H. Huang (1981)
Two types of DNA rearrangements in immunoglobulin genes.Cold Spring Harbor symposia on quantitative biology, 45 Pt 2
-
H. Sakano, K. Hüppi, G. Heinrich, S. Tonegawa (1979)
Sequences at the somatic recombination sites of immunoglobulin light-chain genesNature, 280
-
Bonnie Blomberg, Andre Traunecker, Herman Eisen, Susumu Tonegawa (1981)
Organization of four mouse lambda light chain immunoglobulin genes.Proceedings of the National Academy of Sciences of the United States of America, 78 6
-
S. Dubiski (1969)
Immunochemistry and genetics of a "new" allotypic specificity Ae14 of rabbit gamma-G immunoglobulins: recombination in somatic cells.Journal of immunology, 103 1
-
S. Crews, J. Griffin, Henry Huang, K. Calame, L. Hood (1981)
A single VH gene segment encodes the immune response to phosphorylcholine: Somatic mutation is correlated with the class of the antibodyCell, 25
-
H. Whitehouse (1967)
Crossover Model of Antibody VariabilityNature, 215
-
Mark Davis, K. Calame, P. Early, D. Livant, R. Joho, I. Weissman, L. Hood (1980)
An immunoglobulin heavy-chain gene is formed by at least two recombinational eventsNature, 283
-
Stuart Kim, Mark Davis, E. Sinn, P. Patten, L. Hood (1981)
Antibody diversity: Somatic hypermutation of rearranged VH genesCell, 27
-
N. Hozumi, C. Brack, V. Pirrotta, R. Lenhard-Schuller, S. Tonegawa (1978)
Characterization of a mouse DNA clone containing an immunoglobulin variable region gene.Nucleic acids research, 5 6
-
R. Perry, D. Kelley, C. Coleclough, J. Kearney (1981)
Organization and expression of immunoglobulin genes in fetal liver hybridomas.Proceedings of the National Academy of Sciences of the United States of America, 78 1
-
N. Gough, S. Cory, Jerry Adams (1979)
Identical 3′ non-coding sequences in five mouse Ig κ chain mRNAs favour a unique Cκ geneNature, 281
-
S. Tonegawa, A. Maxam, R. Tizard, O. Bernard, W. Gilbert (1978)
Sequence of a mouse germ-line gene for a variable region of an immunoglobulin light chain.Proceedings of the National Academy of Sciences of the United States of America, 75 3
-
T. Wu, E. Kabat (1970)
AN ANALYSIS OF THE SEQUENCES OF THE VARIABLE REGIONS OF BENCE JONES PROTEINS AND MYELOMA LIGHT CHAINS AND THEIR IMPLICATIONS FOR ANTIBODY COMPLEMENTARITYThe Journal of Experimental Medicine, 132
-
J. Novotný, R. Bruccoleri, J. Newell, D. Murphy, E. Haber, M. Karplus (1983)
Molecular anatomy of the antibody binding site.The Journal of biological chemistry, 258 23
-
J. Seidman, M. Nau, B. Norman, S. Kwan, M. Scharff, P. Leder (1980)
Immunoglobulin V/J recombination is accompanied by deletion of joining site and variable region segments.Proceedings of the National Academy of Sciences of the United States of America, 77 10
-
K. Okumura, M. Julius, T. Tsu, L. Herzenberg, L. Herzenberg (1976)
Demonstration that IgG memory is carried by IgG‐bearing cellsEuropean Journal of Immunology, 6
-
Jonathan Seidman, P. Leder (1978)
The arrangement and rearrangement of antibody genesNature, 276
-
P. D'EUSTACHIO, Dimitrina Pravtcheva, Kenneth Marcu (1980)
Chromosomal location of the structural gene cluster encoding murine immunoglobulin heavy chainsThe Journal of Experimental Medicine, 151
-
K. Danna, G. Sack, D. Nathans (1973)
Studies of simian virus 40 DNA. VII. A cleavage map of the SV40 genome.Journal of molecular biology, 78 2
-
M. Thomas, R. White, R. Davis (1976)
Hybridization of RNA to double-stranded DNA: formation of R-loops.Proceedings of the National Academy of Sciences of the United States of America, 73 7
-
R. Maki, J. Kearney, C. Paige, S. Tonegawa (1980)
Immunoglobulin gene rearrangement in immature B cells.Science, 209 4463
-
C. Wood, S. Tonegawa (1983)
Diversity and joining segments of mouse immunoglobulin heavy chain genes are closely linked and in the same orientation: implications for the joining mechanism.Proceedings of the National Academy of Sciences of the United States of America, 80 10
-
H. Eisen, G. Siskind (1964)
VARIATIONS IN AFFINITIES OF ANTIBODIES DURING THE IMMUNE RESPONSE.Biochemistry, 3
-
G. Matthyssens, T. Rabbitts (1980)
Structure and multiplicity of genes for the human immunoglobulin heavy chain variable region.Proceedings of the National Academy of Sciences of the United States of America, 77 11
-
O. Valbuena, K. Marcu, M. Weigert, R. Perry (1978)
Multiplicity of germline genes specifying a group of related mouse κ chains with implications for the generation of immunoglobulin diversityNature, 276
-
J. Seidman, A. Leder, M. Edgell, F. Polsky, S. Tilghman, D. Tiemeier, P. Leder (1978)
Multiple related immunoglobulin variable-region genes identified by cloning and sequence analysis.Proceedings of the National Academy of Sciences of the United States of America, 75 8
-
R. Dildrop, M. Brüggemann, Andreas Radbruch, K. Rajewsky, K. Beyreuther (1982)
Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes.The EMBO Journal, 1
-
H. Sheppard, G. Gutman (1982)
Rat kappa-chain J-segment genes: Two recent gene duplications separate rat and mouseCell, 29
-
M. Weigert, R. Riblet (1977)
Genetic control of antibody variable regions.Cold Spring Harbor symposia on quantitative biology, 41 Pt 2
-
Jim Miller, E. Selsing, U. Storb (1982)
Structural alterations in J regions of mouse immunoglobulin λ genes are associated with differential gene expressionNature, 295
-
Sydney Brenner, Cesar Milstein (1966)
Origin of Antibody VariationNature, 211
-
D. McKean, K. Huppi, M. Bell, L. Staudt, W. Gerhard, M. Weigert (1984)
Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.Proceedings of the National Academy of Sciences of the United States of America, 81 10
-
H. Gershenfeld, A. Tsukamoto, I. Weissman, R. Joho (1981)
Somatic diversification is required to generate the V kappa genes of MOPC 511 and MOPC 167 myeloma proteins.Proceedings of the National Academy of Sciences of the United States of America, 78 12
-
A. Gelderman, A. Rake, R. Britten (1971)
Transcription of nonrepeated DNA in neonatal and fetal mice.Proceedings of the National Academy of Sciences of the United States of America, 68 1
-
R. Zakut, Justus Cohen, D. Givol (1980)
Cloning and sequence of the cDNA corresponding to the variable region of immunoglobulin heavy chain MPC11Nucleic Acids Research, 8
-
T. Azuma, L. Steiner, H. Eisen (1981)
Identification of a third type of lambda light chain in mouse immunoglobulins.Proceedings of the National Academy of Sciences of the United States of America, 78 1
-
M. Cohn (1970)
Selection under a somatic model.Cellular immunology, 1 5
-
K. Marcu (1982)
Immunoglobulin heavy-chain constant-region genesCell, 29
-
M. Knapp, C. Liu, N. Newell, R. Ward, P. Tucker, S. Strober, F. Blattner (1982)
Simultaneous expression of immunoglobulin mu and delta heavy chains by a cloned B-cell lymphoma: a single copy of the VH gene is shared by two adjacent CH genes.Proceedings of the National Academy of Sciences of the United States of America, 79 9
-
B. Askonas, A. Williamson (1972)
Factors affecting the propagation of a B Cell Clone forming antibody to the 2,4‐dinitrophenyl groupEuropean Journal of Immunology, 2
-
C. Brack, M. Hirama, R. Lenhard-Schuller, S. Tonegawa (1978)
A complete immunoglobulin gene is created by somatic recombinationCell, 15
-
F. Burnet (1959)
The clonal selection theory of acquired immunity -
E. Selsing, U. Storb (1981)
Somatic mutation of immunoglobulin light-chain variable-region genesCell, 25
-
E. Max, J. Seidman, P. Leder (1979)
Sequences of five potential recombination sites encoded close to an immunoglobulin kappa constant region gene.Proceedings of the National Academy of Sciences of the United States of America, 76 7
-
B. Ness, Christopher Coleclough, Robert Perry, Martin Weigert (1982)
DNA between variable and joining gene segments of immunoglobulin kappa light chain is frequently retained in cells that rearrange the kappa locus.Proceedings of the National Academy of Sciences of the United States of America, 79 2
-
K. Moore, J. Rogers, T. Hunkapiller, P. Early, C. Nottenburg, I. Weissman, H. Bazin, R. Wall, L. Hood (1981)
Expression of IgD may use both DNA rearrangement and RNA splicing mechanisms.Proceedings of the National Academy of Sciences of the United States of America, 78 3
-
G. Edelman (1973)
Antibody structure and molecular immunology.Science, 180 4088
-
D. Baltimore (1981)
Somatic mutation gains its place among the generators of diversityCell, 26
-
L. Hood, D. Talmage (1970)
Mechanism of antibody diversity: germ line basis for variability.Science, 168 3929
-
N. Hozumi, G. Wu, H. Murialdo, L. Roberts, D. Vetter, W. Fife, M. Whiteley, P. Sadowski (1981)
RNA splicing mutation in an aberrantly rearranged immunoglobulin lambda I gene.Proceedings of the National Academy of Sciences of the United States of America, 78 11
-
T. Rabbitts, A. Forster (1978)
Evidence for noncontiguous variable and constant region genes in both germ line and myeloma DNACell, 13
-
M. Weigert, Italo Cesari, S. Yonkovich, M. Cohn (1970)
Variability in the Lambda Light Chain Sequences of Mouse AntibodyNature, 228
-
E. Southern (1975)
Detection of specific sequences among DNA fragments separated by gel electrophoresis.Journal of molecular biology, 98 3
-
S. Tonegawa (1976)
Reiteration frequency of immunoglobulin light chain genes: further evidence for somatic generation of antibody diversity.Proceedings of the National Academy of Sciences of the United States of America, 73 1
-
Y. Kurosawa, S. Tonegawa (1982)
Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segmentsThe Journal of Experimental Medicine, 155
-
B. Blomberg, S. Tonegawa (1982)
DNA sequences of the joining regions of mouse lambda light chain immunoglobulin genes.Proceedings of the National Academy of Sciences of the United States of America, 79 2
-
D. Davies, E. Padlan, D. Segal (1975)
Three-dimensional structure of immunoglobulins.Annual review of biochemistry, 44
-
A. Bothwell, M. Paskind, M. Reth, T. Imanishi‐Kari, K. Rajewsky, D. Baltimore (1981)
Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a γ2a variable regionCell, 24
-
S. Tonegawa, C. Brack, N. Hozumi, R. Schuller (1977)
Cloning of an immunoglobulin variable region gene from mouse embryo.Proceedings of the National Academy of Sciences of the United States of America, 74 8
-
Martin Weigert, L. Gatmaitan, E. Loh, J. Schilling, J. Schilling, L. Hood (1978)
Rearrangement of genetic information may produce immunoglobulin diversityNature, 276
-
A. Shimizu, N. Takahashi, Y. Yaoita, T. Honjo (1982)
Organization of the constant-region gene family of the mouse immunoglobulin heavy chainCell, 28
-
D. McKean, M. Bell, M. Potter (1978)
Mechanisms of antibody diversity: multiple genes encode structurally related mouse kappa variable regions.Proceedings of the National Academy of Sciences of the United States of America, 75 8
-
S. Tonegawa, N. Hozumi, G. Matthyssens, R. Schuller (1977)
Somatic changes in the content and context of immunoglobulin genes.Cold Spring Harbor symposia on quantitative biology, 41 Pt 2
-
P. Early, C. Nottenburg, I. Weissman, L. Hood (1982)
Immunoglobulin gene rearrangements in normal mouse B cellsMolecular and Cellular Biology, 2
-
R. Lenhard-Schuller, B. Hohn, C. Brack, M. Hirama, S. Tonegawa (1978)
DNA clones containing mouse immunoglobulin kappa chain genes isolated by in vitro packaging into phage lambda coats.Proceedings of the National Academy of Sciences of the United States of America, 75 10
-
D. Swan, P. D’Eustachio, L. Leinwand, J. Seidman, D. Keithley, F. Ruddle (1979)
Chromosomal assignment of the mouse kappa light chain genes.Proceedings of the National Academy of Sciences of the United States of America, 76 6
-
M. Weigert, R. Perry, D. Kelley, T. Hunkapiller, J. Schilling, L. Hood (1980)
The joining of V and J gene segments creates antibody diversityNature, 283
-
J. Lederberg (1959)
Genes and antibodies.Science, 129 3364
-
C. Brack, S. Tonegawa (1977)
Variable and constant parts of the immunoglobulin light chain gene of a mouse myeloma cell are 1250 nontranslated bases apart.Proceedings of the National Academy of Sciences of the United States of America, 74 12
-
D. Givol, R. Zakut, K. Effron, G. Rechavi, D. Ram, Justus Cohen (1981)
Diversity of germ-line immunoglobulin VH genesNature, 292
-
M. Pech, J. Höchtl, H. Schnell, H. Zachau (1981)
Differences between germ-line and rearranged immunoglobulin Vκ coding sequences suggest a localized mutation mechanismNature, 291
-
John Bishop (1972)
Molecular hybridization of ribonucleic acid with a large excess of deoxyribonucleic acid.The Biochemical journal, 126 1
-
A. Walfield, E. Selsing, B. Arp, U. Storb (1981)
Misalignment of V and J gene segments resulting in a nonfunctional immunoglobulin gene.Nucleic acids research, 9 5
-
T. Kataoka, T. Miyata, T. Honjo (1981)
Repetitive sequences in class-switch recombination regions of immunoglobulin heavy chain genesCell, 23
-
P. Early, John Rogers, Mark Davis, K. Calame, M. Bond, Randolph Wall, Leroy Hood (1980)
Two mRNAs can be produced from a single immunoglobulin μ gene by alternative RNA processing pathwaysCell, 20
-
H. Hengartner, T. Méo, E. Müller (1978)
Assignment of genes for immunoglobulin kappa and heavy chains to chromosomes 6 and 12 in mouse.Proceedings of the National Academy of Sciences of the United States of America, 75 9
-
W. Altenburger, M. Steinmetz, H. Zachau (1980)
Functional and non-functional joining in immunoglobulin light chain genes of a mouse myelomaNature, 287
-
T. Azuma, V. Igras, E. Reilly, H. Eisen (1984)
Diversity at the variable-joining region boundary of lambda light chains has a pronounced effect on immunoglobulin ligand-binding activity.Proceedings of the National Academy of Sciences of the United States of America, 81 19
-
P. Hieter, S. Korsmeyer, T. Waldmann, P. Leder (1981)
Human immunoglobulin κ light-chain genes are deleted or rearranged in λ-producing B cellsNature, 290
-
S. Lewis, N. Rosenberg, F. Alt, D. Baltimore (1982)
Continuing kappa-gene rearrangement in a cell line transformed by Abelson murine leukemia virusCell, 30
-
E. Selsing, U. Storb (1981)
Mapping of immunoglobulin variable region genes: relationship to the 'deletion' model of immunoglobulin gene rearrangement.Nucleic acids research, 9 21
-
P. D’Eustachio, A. Bothwell, T. Takaro, D. Baltimore, F. Ruddle (1981)
Chromosomal location of structural genes encoding murine immunoglobulin lambda light chains. Genetics of murine lambda light chainsThe Journal of Experimental Medicine, 153
-
P. Early, L. Hood (1981)
Allelic exclusion and nonproductive immunoglobulin gene rearrangementsCell, 24
-
P. Early, Mark Davis, David Kaback, Norman Davidson, Leroy Hood (1979)
Immunoglobulin heavy chain gene organization in mice: analysis of a myeloma genomic clone containing variable and alpha constant regions.Proceedings of the National Academy of Sciences of the United States of America, 76 2
-
J. Gally, Gerald Edelman (1970)
Somatic Translocation of Antibody GenesNature, 227
-
T. Kindt, W. Mandy, C. Todd (1970)
Association of allotypic specificities of group a with allotypic specificities A11 and A12 in rabbit immunoglobulin.Biochemistry, 9 9
-
P. Tucker, C. Liu, J. Mushinski, F. Blattner (1980)
Mouse immunoglobulin D: messenger RNA and genomic DNA sequences.Science, 209 4463
-
H. Sakano, J. Rogers, K. Hüppi, C. Brack, A. Traunecker, R. Maki, R. Wall, S. Tonegawa (1979)
Domains and the hinge region of an immunoglobulin heavy chain are encoded in separate DNA segmentsNature, 277
-
B. Elliott, H. Eisen, L. Steiner (1982)
Unusual association of V, J and C regions in a mouse immunoglobulin λ chainNature, 299
-
John Rogers, P. Early, Carla Carter, K. Calame, M. Bond, L. Hood, Randolph Wall (1980)
Two mRNAs with different 3′ ends encode membrane-bound and secreted forms of immunoglobulin μ chainCell, 20
-
H. Sakano, Y. Kurosawa, M. Weigert, S. Tonegawa (1981)
Identification and nucleotide sequence of a diversity DNA segment (D) of immunoglobulin heavy-chain genesNature, 290
-
J. Schilling, B. Clevinger, Joseph Davie, L. Hood (1980)
Amino acid sequence of homogeneous antibodies to dextran and DNA rearrangments in heavy chain V-region gene segmentsNature, 283
-
O. Bernard, N. Hozumi, S. Tonegawa (1978)
Sequences of mouse immunoglobulin light chain genes before and after somatic changesCell, 15
-
T. Honjo, T. Kataoka, Y. Yaoita, A. Shimizu, N. Takahashi, Y. Yamawaki‐Kataoka, T. Nikaido, S. Nakai, M. Obata, T. Kawakami, Y. Nishida (1981)
Organization and reorganization of immunoglobulin heavy-chain genes.Cold Spring Harbor symposia on quantitative biology, 45 Pt 2
-
M. Obata, T. Kataoka, S. Nakai, H. Yamagishi, N. Takahashi, Y. Yamawaki‐Kataoka, T. Nikaido, A. Shimizu, T. Honjo (1981)
Structure of a rearranged gamma 1 chain gene and its implication to immunoglobulin class-switch mechanism.Proceedings of the National Academy of Sciences of the United States of America, 78 4
-
S. Tosi, S. Dubiski, R. Mage (1970)
Distribution of allotypic specificities A1, A2, A14, and A15 among immunoglobulin G molecules.Journal of immunology, 104 3
-
N. Jerne (1955)
THE NATURAL-SELECTION THEORY OF ANTIBODY FORMATION.Proceedings of the National Academy of Sciences of the United States of America, 41 11
-
P. Gearhart, N. Johnson, R. Douglas, L. Hood (1981)
IgG antibodies to phosphorylcholine exhibit more diversity than their IgM counterpartsNature, 291
-
P. Schreier, A. Bothwell, B. Mueller-Hill, D. Baltimore (1981)
Multiple differences between the nucleic acid sequences of the IgG2aa and IgG2ab alleles of the mouse.Proceedings of the National Academy of Sciences of the United States of America, 78 7
-
T. Rabbitts, G. Matthyssens, P. Hamlyn (1980)
Contribution of immunoglobulin heavy-chain variable-region genes to antibody diversityNature, 284
-
Y. Kurosawa, H. Boehmer, W. Haas, H. Sakano, André Trauneker, S. Tonegawa (1981)
Identification of D segments of immunoglobulin heavy-chain genes and their rearrangement in T lymphocytesNature, 290
-
F. Alt, A. Bothwell, Michael Knapp, E. Siden, E. Mather, M. Koshland, D. Baltimore (1980)
Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3′ endsCell, 20
-
E. Dugan, R. Bradshaw, E. Simms, H. Eisen (1973)
Amino acid sequence of the light chain of a mouse myeloma protein (MOPC-315).Biochemistry, 12 26
-
O. Smithies (1967)
Antibody VariabilityScience, 157
-
R. Mage, R. Lieberman, M. Potter, W. Terry (1973)
CHAPTER 4 – Immunoglobulin Allotypes -
J. Höchtl, H. Zachau (1983)
A novel type of aberrant recombination in immunoglobulin genes and its implications for V–J joining mechanismNature, 302
-
F. Alt, D. Baltimore (1982)
Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions.Proceedings of the National Academy of Sciences of the United States of America, 79 13
- Publisher
- Springer Journals
- Copyright
- Copyright © 1983 by Nature Publishing Group
- Subject
- Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- DOI
- 10.1038/302575a0
- Publisher site
- See Article on Publisher Site
Abstract
In the genome of a germ-line cell, the genetic information for an immunoglobulin polypeptide chain is contained in multiple gene segments scattered along a chromosome. During the development of bone marrow-derived lymphocytes, these gene segments are assembled by recombination which leads to the formation of a complete gene. In addition, mutations are somatically introduced at a high rate into the amino-terminal region. Both somatic recombination and mutation contribute greatly to an increase in the diversity of antibody synthesized by a single organism.
Journal
Nature – Springer Journals
Published: Apr 14, 1983