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References (76)
-
H. Jonuleit, E. Schmitt, G. Schuler, J. Knop, A. Enk (2000)
Induction of Interleukin 10–Producing, Nonproliferating Cd4+ T Cells with Regulatory Properties by Repetitive Stimulation with Allogeneic Immature Human Dendritic CellsThe Journal of Experimental Medicine, 192
-
C. Ito, A. Kazantsev, A. Baldwin (1994)
Three NF-kappa B sites in the I kappa B-alpha promoter are required for induction of gene expression by TNF alpha.Nucleic acids research, 22 18
-
B. Tian, David Nowak, M. Jamaluddin, Shao-Kai Wang, A. Brasier (2005)
Identification of Direct Genomic Targets Downstream of the Nuclear Factor-κB Transcription Factor Mediating Tumor Necrosis Factor Signaling*Journal of Biological Chemistry, 280
-
U. Senftleben, Y. Cao, G. Xiao, F. Greten, G. Krähn, G. Bonizzi, Y. Chen, Y. Hu, A. Fong, S. Sun, M. Karin (2001)
Activation by IKKalpha of a second, evolutionary conserved, NF-kappa B signaling pathway.Science, 293 5534
-
K. Pilkington, I. Clark‐Lewis, S. McColl (2004)
Inhibition of Generation of Cytotoxic T Lymphocyte Activity by a CCL19/Macrophage Inflammatory Protein (MIP)-3β Antagonist*Journal of Biological Chemistry, 279
-
Kunsch (1993)
NF-kappa B subunit-specific regulation of the interleukin-8 promoterMol. Cell. Biol., 13
-
J. Vissers, F. Hartgers, E. Lindhout, C. Figdor, G. Adema (2001)
BLC (CXCL13) is expressed by different dendritic cell subsets in vitro and in vivoEuropean Journal of Immunology, 31
-
C. Smith, E. Andreakos, J. Crawley, F. Brennan, M. Feldmann, B. Foxwell (2001)
NF-kappaB-inducing kinase is dispensable for activation of NF-kappaB in inflammatory settings but essential for lymphotoxin beta receptor activation of NF-kappaB in primary human fibroblasts.Journal of immunology, 167 10
-
V. Souvannavong, N. Saidji, R. Chaby (2007)
Lipopolysaccharide from Salmonella enterica Activates NF-κB through both Classical and Alternative Pathways in Primary B LymphocytesInfection and Immunity, 75
-
F. Ouaaz, J. Arron, Ye Zheng, Yongwon Choi, A. Beg (2002)
Dendritic cell development and survival require distinct NF-kappaB subunits.Immunity, 16 2
-
N. Cools, P. Ponsaerts, V. Tendeloo, Z. Berneman (2007)
Balancing between immunity and tolerance: an interplay between dendritic cells, regulatory T cells, and effector T cellsJournal of Leukocyte Biology, 82
-
G. Bonizzi, M. Karin (2004)
The two NF-kappaB activation pathways and their role in innate and adaptive immunity.Trends in immunology, 25 6
-
G. Bren, N. Solan, H. Miyoshi, K. Pennington, L. Pobst, C. Payá (2001)
Transcription of the RelB gene is regulated by NF-kappaB.Oncogene, 20 53
-
B. O’Sullivan, K. Macdonald, A. Pettit, Ranjeny Thomas (2000)
RelB nuclear translocation regulates B cell MHC molecule, CD40 expression, and antigen-presenting cell function.Proceedings of the National Academy of Sciences of the United States of America, 97 21
-
P. Dobrzanski, R. Ryseck, R. Bravo (1994)
Differential interactions of Rel‐NF‐kappa B complexes with I kappa B alpha determine pools of constitutive and inducible NF‐kappa B activity.The EMBO Journal, 13
-
S. Malek, De-bin Huang, T. Huxford, S. Ghosh, G. Ghosh (2003)
X-ray Crystal Structure of an IκBβ·NF-κB p65 Homodimer Complex*Journal of Biological Chemistry, 278
-
E. Dejardin, N. Droin, M. Delhase, E. Haas, Yixue Cao, C. Makris, Zhi-wei Li, M. Karin, C. Ware, D. Green (2002)
The Lymphotoxin-β Receptor Induces Different Patterns of Gene Expression via Two NF-κB PathwaysImmunity, 17
-
M. Suhasini, R. Pilz (1999)
Transcriptional elongation of c-myb is regulated by NF-kappaB (p50/RelB).Oncogene, 18 51
-
M. Neumann, H. Fries, C. Scheicher, P. Keikavoussi, A. Kolb-Mäurer, E. Bröcker, E. Serfling, E. Kämpgen (2000)
Differential expression of Rel/NF-κB and octamer factors is a hallmark of the generation and maturation of dendritic cellsBlood, 95
-
S. Hofer, M. Rescigno, F. Granucci, S. Citterio, M. Francolini, P. Ricciardi-Castagnoli (2001)
Differential activation of NF-kappa B subunits in dendritic cells in response to Gram-negative bacteria and to lipopolysaccharide.Microbes and infection, 3 4
-
P. Dobrzanski, R. Ryseck, Rodrigo Bravo (1995)
Specific inhibition of RelB/p52 transcriptional activity by the C-terminal domain of p100.Oncogene, 10 5
-
Thomas Leung, A. Hoffmann, D. Baltimore (2004)
One Nucleotide in a κB Site Can Determine Cofactor Specificity for NF-κB DimersCell, 118
-
G. Bonizzi, M. Bébien, D. Otero, Kirsten Johnson-Vroom, Yixue Cao, D. Vu, A. Jegga, B. Aronow, G. Ghosh, R. Rickert, M. Karin (2004)
Activation of IKKalpha target genes depends on recognition of specific kappaB binding sites by RelB:p52 dimers.The EMBO journal, 23 21
-
S. Saccani, Serafino Pantano, G. Natoli (2003)
Modulation of NF-kappaB activity by exchange of dimers.Molecular cell, 11 6
-
S. Luther, H. Tang, P. Hyman, A. Farr, J. Cyster (2000)
Coexpression of the chemokines ELC and SLC by T zone stromal cells and deletion of the ELC gene in the plt/plt mouse.Proceedings of the National Academy of Sciences of the United States of America, 97 23
-
B. Tian, David Nowak, A. Brasier (2005)
A TNF-induced gene expression program under oscillatory NF-κB controlBMC Genomics, 6
-
A. Kaiser, E. Donnadieu, J. Abastado, A. Trautmann, A. Nardin (2005)
CC Chemokine Ligand 19 Secreted by Mature Dendritic Cells Increases Naive T Cell Scanning Behavior and Their Response to Rare Cognate AntigenThe Journal of Immunology, 175
-
Clive Smith, E. Andreakos, J. Crawley, F. Brennan, M. Feldmann, B. Foxwell (2001)
NF-κB-Inducing Kinase Is Dispensable for Activation of NF-κB in Inflammatory Settings but Essential for Lymphotoxin β Receptor Activation of NF-κB in Primary Human Fibroblasts1The Journal of Immunology, 167
-
Y. Yanagawa, K. Onoé (2002)
CCL19 induces rapid dendritic extension of murine dendritic cells.Blood, 100 6
-
S. Saccani, Serafino Pantano, G. Natoli (2003)
Modulation of NF-κB Activity by Exchange of DimersMolecular Cell, 11
-
Jane Linnell, R. Mott, Simon Field, D. Kwiatkowski, J. Ragoussis, I. Udalova (2004)
Quantitative high-throughput analysis of transcription factor binding specificities.Nucleic acids research, 32 4
-
J. Pomerantz, D. Baltimore (2002)
Two pathways to NF-kappaB.Molecular cell, 10 4
-
D. Carrasco, R. Ryseck, R. Bravo (1993)
Expression of relB transcripts during lymphoid organ development: specific expression in dendritic antigen-presenting cells.Development, 118 4
-
S. Yoshimura, J. Bondeson, B. Foxwell, F. Brennan, M. Feldmann (2001)
Effective antigen presentation by dendritic cells is NF-kappaB dependent: coordinate regulation of MHC, co-stimulatory molecules and cytokines.International immunology, 13 5
-
S. Parlato, S. Santini, C. Lapenta, T. Pucchio, M. Logozzi, M. Spada, A. Giammarioli, W. Malorni, S. Fais, F. Belardelli (2001)
Expression of CCR-7, MIP-3beta, and Th-1 chemokines in type I IFN-induced monocyte-derived dendritic cells: importance for the rapid acquisition of potent migratory and functional activities.Blood, 98 10
-
Emmanuel Derudder, E. Dejardin, L. Pritchard, D. Green, M. Korner, V. Baud (2003)
RelB/p50 dimers are differentially regulated by tumor necrosis factor-alpha and lymphotoxin-beta receptor activation: critical roles for p100.The Journal of biological chemistry, 278 26
-
E. Dejardin, N. Droin, M. Delhase, E. Haas, Yixue Cao, C. Makris, Zhi-wei Li, M. Karin, C. Ware, D. Green (2002)
The lymphotoxin-beta receptor induces different patterns of gene expression via two NF-kappaB pathways.Immunity, 17 4
-
J. Lo, S. Basak, E. James, Raechel Quiambo, Marcus Kinsella, M. Alegre, F. Weih, G. Franzoso, A. Hoffmann, yang-xin fu (2006)
Coordination between NF-kappaB family members p50 and p52 is essential for mediating LTbetaR signals in the development and organization of secondary lymphoid tissues.Blood, 107 3
-
C. Ito, A. Kazantsev, A. Baldwin (1994)
Three NF-χB sites in the IχB-α promoter are required for induction of gene expression by TNFαNucleic Acids Research, 22
-
B. Moser, M. Wolf, A. Walz, P. Loetscher (2004)
Chemokines: multiple levels of leukocyte migration control.Trends in immunology, 25 2
-
S. McColl (2002)
Chemokines and dendritic cells: A crucial allianceImmunology and Cell Biology, 80
-
M. Neumann, H.-W. Fries, C. Scheicher, P. Keikavoussi, A. Kolb-Mäurer, E.-B. Bröcker, E. Serfling, E. Kämpgen (2000)
Differential expression of Rel/NF-kappaB and octamer factors is a hallmark of the generation and maturation of dendritic cells.Blood, 95 1
-
K. Speirs, L. Lieberman, J. Caamaño, C. Hunter, P. Scott (2004)
Cutting edge: NF-kappa B2 is a negative regulator of dendritic cell function.Journal of immunology, 172 2
-
M. Suhasini, R. Pilz (1999)
Transcriptional elongation of c-myb is regulated by NF-κB (p50/RelB)Oncogene, 18
-
M. Lutz, G. Schuler (2002)
Immature, semi-mature and fully mature dendritic cells: which signals induce tolerance or immunity?Trends in immunology, 23 9
-
U. Senftleben, Yixue Cao, G. Xiao, F. Greten, G. Krähn, G. Bonizzi, Yi Chen, Yinling Hu, A. Fong, Shao-Cong Sun, M. Karin (2001)
Activation by IKKα of a Second, Evolutionary Conserved, NF-κB Signaling PathwayScience, 293
-
A. Hoffmann, Thomas Leung, D. Baltimore (2003)
Genetic analysis of NF‐κB/Rel transcription factors defines functional specificitiesThe EMBO Journal, 22
-
E. Andreakos, Clive Smith, C. Monaco, F. Brennan, B. Foxwell, M. Feldmann (2003)
Ikappa B kinase 2 but not NF-kappa B-inducing kinase is essential for effective DC antigen presentation in the allogeneic mixed lymphocyte reaction.Blood, 101 3
-
J. Caamaño, J. Alexander, Linden Craig, R. Bravo, C. Hunter (1999)
The NF-kappa B family member RelB is required for innate and adaptive immunity to Toxoplasma gondii.Journal of immunology, 163 8
-
J. Cyster (1999)
Chemokines and cell migration in secondary lymphoid organs.Science, 286 5447
-
G. Clark, S. Gunningham, A. Troy, S. Vuckovic, D. Hart (1999)
Expression of the RelB transcription factor correlates with the activation of human dendritic cellsImmunology, 98
-
G. Bonizzi, M. Karin (2004)
The two NF-κB activation pathways and their role in innate and adaptive immunityTrends in Immunology, 25
-
A. Pettit, C. Quinn, K. Macdonald, L. Cavanagh, G. Thomas, W. Townsend, Malcolm Handel, Ranjeny Thomas (1997)
Nuclear localization of RelB is associated with effective antigen-presenting cell function.Journal of immunology, 159 8
-
R. Förster, A. Schubel, D. Breitfeld, E. Kremmer, I. Renner-Müller, E. Wolf, M. Lipp (1999)
CCR7 Coordinates the Primary Immune Response by Establishing Functional Microenvironments in Secondary Lymphoid OrgansCell, 99
-
C. Caux, B. Vanbervliet, C. Massacrier, S. Ait-Yahia, Céline Vaure, K. Chemin, M. Dieu-Nosjean, A. Vicari (2002)
REGULATION OF DENDRITIC CELL RECRUITMENT BY CHEMOKINESTransplantation, 73
-
C. Ammon, Krishna Mondal, Reinhard Andreesen, Stefan Krause (2000)
Differential expression of the transcription factor NF-kappaB during human mononuclear phagocyte differentiation to macrophages and dendritic cells.Biochemical and biophysical research communications, 268 1
-
Dobrzanski (1993)
Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motifMol. Cell. Biol., 13
-
F. Katou, H. Ohtani, T. Nakayama, H. Nagura, O. Yoshie, K. Motegi (2003)
Differential expression of CCL19 by DC‐Lamp+ mature dendritic cells in human lymph node versus chronically inflamed skinThe Journal of Pathology, 199
-
P. Dobrzanski, R. Ryseck, R. Bravo (1993)
Both N- and C-terminal domains of RelB are required for full transactivation: role of the N-terminal leucine zipper-like motifMolecular and Cellular Biology, 13
-
I. Baltathakis, O. Alcantara, D. Boldt (2001)
Expression of different NF‐κB pathway genes in dendritic cells (DCs) or macrophages assessed by gene expression profilingJournal of Cellular Biochemistry, 83
-
T. Pietilä, V. Veckman, A. Lehtonen, R. Lin, J. Hiscott, I. Julkunen (2007)
Multiple NF-κB and IFN Regulatory Factor Family Transcription Factors Regulate CCL19 Gene Expression in Human Monocyte-Derived Dendritic Cells1The Journal of Immunology, 178
-
Thomas Leung, A. Hoffmann, D. Baltimore (2004)
One nucleotide in a kappaB site can determine cofactor specificity for NF-kappaB dimers.Cell, 118 4
-
Emmanuel Derudder, E. Dejardin, L. Pritchard, D. Green, M. Körner, V. Baud (2003)
RelB/p50 dimers are differentially regulated by TNF-α and lymphotoxin-β receptor activation: critical roles for p100Journal of Biological Chemistry
-
C. Kunsch, C. Rosen (1993)
NF-kappa B subunit-specific regulation of the interleukin-8 promoterMolecular and Cellular Biology, 13
-
F. Ouaaz, J. Arron, Ye Zheng, Yongwon Choi, A. Beg (2002)
Dendritic Cell Development and Survival Require Distinct NF-κB SubunitsImmunity, 16
-
J. Pomerantz, D. Baltimore (2002)
Two Pathways to NF-κBMolecular Cell, 10
-
H. Tang, J. Cyster (1999)
Chemokine Up-regulation and activated T cell attraction by maturing dendritic cells.Science, 284 5415
-
R. Ten, C. Payá, N. Israël, O. Bail, M. Mattei, J. Virelizier, P. Kourilsky, A. Israël (1992)
The characterization of the promoter of the gene encoding the p50 subunit of NF‐kappa B indicates that it participates in its own regulation.The EMBO Journal, 11
-
W. Weninger, U. Andrian (2003)
Chemokine regulation of naïve T cell traffic in health and disease.Seminars in immunology, 15 5
-
T. Pietilä, V. Veckman, A. Lehtonen, R. Lin, J. Hiscott, I. Julkunen (2007)
Multiple NF-kappaB and IFN regulatory factor family transcription factors regulate CCL19 gene expression in human monocyte-derived dendritic cells.Journal of immunology, 178 1
-
T.-C. He, S. Zhou, L. Costa, J. Yu, K. Kinzler, B. Vogelstein (1998)
A simplified system for generating recombinant adenoviruses.Proceedings of the National Academy of Sciences of the United States of America, 95 5
-
K. Speirs, L. Lieberman, J. Caamaño, C. Hunter, P. Scott (2004)
Cutting Edge: NF-κB2 Is a Negative Regulator of Dendritic Cell Function1The Journal of Immunology, 172
-
A. Moorthy, De-bin Huang, V. Wang, D. Vu, G. Ghosh (2007)
X-ray structure of a NF-kappaB p50/RelB/DNA complex reveals assembly of multiple dimers on tandem kappaB sites.Journal of molecular biology, 373 3
-
G. Bonizzi, M. Bébien, D. Otero, Kirsten Johnson-Vroom, Yixue Cao, D. Vu, A. Jegga, B. Aronow, G. Ghosh, R. Rickert, M. Karin (2004)
Activation of IKKα target genes depends on recognition of specific κB binding sites by RelB:p52 dimersThe EMBO Journal, 23
-
V. Ngo, H. Tang, J. Cyster (1998)
Epstein-Barr Virus–induced Molecule 1 Ligand Chemokine Is Expressed by Dendritic Cells in Lymphoid Tissues and Strongly Attracts Naive T Cells and Activated B CellsThe Journal of Experimental Medicine, 188
-
Ryuuta Yoshida, M. Nagira, Motoji Kitaura, N. Imagawa, T. Imai, O. Yoshie (1998)
Secondary Lymphoid-tissue Chemokine Is a Functional Ligand for the CC Chemokine Receptor CCR7*The Journal of Biological Chemistry, 273
- Publisher
- Wiley
- Copyright
- Copyright © 2009 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim
- ISSN
- 0014-2980
- eISSN
- 1521-4141
- DOI
- 10.1002/eji.200939209
- pmid
- 19655301
- Publisher site
- See Article on Publisher Site
Abstract
DC, when fully matured are the APC best able to activate naïve T cells. Recently, we demonstrated using adenoviruses overexpressing IκBα and proteosome inhibitors that NF‐κB is involved in DC activation, but the role of the individual subunits is still not clear. We investigated the role of the NF‐κB subunits RelB and p50 in human DC activation using adenoviral vectors expressing RelB or p50. Nuclear RelB, in the form of RelB/p50, was active only in DC infected with both viruses, this induced the production of the soluble homeostatic chemokine CCL19, but not other homeostatic chemokines, particularly in LPS‐matured DC. However, RelB/p50 did not affect the expression of costimulatory and antigen‐presenting molecules, and increased the allogeneic mixed lymphocyte reaction only in LPS‐matured DC. This enhanced mixed lymphocyte reaction is most likely due to enhanced CCL19 production, which sustains the interaction between mature DC and naïve T cells. In conclusion, we demonstrated that RelB/p50 was active only in DC expressing both RelB and p50, and induced CCL19 production, but not DC maturation.
Journal
European Journal of Immunology – Wiley
Published: Aug 1, 2009