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The effect of slaframine on salivary output and subacute and acute acidosis in growing beef steers

The effect of slaframine on salivary output and subacute and acute acidosis in growing beef steers Abstract Experiments were conducted to determine 1) the effect of injecting slaframine (SF) on salivary output in growing beef steers and 2) whether increased salivary output after SF injection would inhibit the decrease in ruminal pH that occurs after experimentally induced subacute and acute ruminal acidosis. In Exp. 1 and 2, we measured ruminal pH and salivary output in ruminally and esophageally cannulated beef steers fed an 88% concentrate diet. Injections of 66 or 100 µg of SF/kg BW increased salivary flow approximately 50% compared with controls. Those doses were tested in subacute and acute acidosis models using ruminally cannulated beef steers in Exp. 3 and 4, respectively. In these experiments, salivation was assessed indirectly using a visual scoring system. In the subacute acidosis model, SF reduced (P < .10) the decrease in ruminal pH (1.1, .7, and .6 pH units for control, 66, and 100 µg of SF/kg BW doses, respectively), and excessive salivation was observed in all SF-injected steers. In the acute acidosis model, there were no differences (P > .10) in ruminal pH at 12 h after injection between control and SF-treated steers. Mean ruminal lactate concentrations for all treatment groups were between 87 and 112 mM. Although treatment with 66 µg of SF/kg BW reduced (P < .10) ruminal lactate concentrations, all ruminal lactate concentrations were indicative of acute acidosis. These results indicate that SF will reduce the decrease in ruminal pH associated with subacute acidosis in growing beef steers, but SF does not attenuate acute ruminal acidosis. This content is only available as a PDF. Author notes 2 The authors are grateful to R. L. Bell for animal support, K. Barsuhn, M. M. Johnson, A. R. Cazers, J. L. Nappier, and G. A. Hoffman for laboratory support, V. P. Marshall for fermentation work, W. J. Smolenski for data capture, K. J. Dame for data handling, and L. Munyakazi for statistical support. 4 Present address: A. L. Laboratories, One Executive Dr., Fort Lee, NJ 07024. 5 Dept. of Anim. Sci. and Poult. Sci., North Carolina State Univ., Raleigh 27695. Copyright © 1995 by American Society of Animal Science http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Animal Science Oxford University Press

The effect of slaframine on salivary output and subacute and acute acidosis in growing beef steers

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References (15)

Copyright
Copyright © 1995 by American Society of Animal Science
ISSN
0021-8812
eISSN
1525-3163
DOI
10.2527/1995.732516x
Publisher site
See Article on Publisher Site

Abstract

Abstract Experiments were conducted to determine 1) the effect of injecting slaframine (SF) on salivary output in growing beef steers and 2) whether increased salivary output after SF injection would inhibit the decrease in ruminal pH that occurs after experimentally induced subacute and acute ruminal acidosis. In Exp. 1 and 2, we measured ruminal pH and salivary output in ruminally and esophageally cannulated beef steers fed an 88% concentrate diet. Injections of 66 or 100 µg of SF/kg BW increased salivary flow approximately 50% compared with controls. Those doses were tested in subacute and acute acidosis models using ruminally cannulated beef steers in Exp. 3 and 4, respectively. In these experiments, salivation was assessed indirectly using a visual scoring system. In the subacute acidosis model, SF reduced (P < .10) the decrease in ruminal pH (1.1, .7, and .6 pH units for control, 66, and 100 µg of SF/kg BW doses, respectively), and excessive salivation was observed in all SF-injected steers. In the acute acidosis model, there were no differences (P > .10) in ruminal pH at 12 h after injection between control and SF-treated steers. Mean ruminal lactate concentrations for all treatment groups were between 87 and 112 mM. Although treatment with 66 µg of SF/kg BW reduced (P < .10) ruminal lactate concentrations, all ruminal lactate concentrations were indicative of acute acidosis. These results indicate that SF will reduce the decrease in ruminal pH associated with subacute acidosis in growing beef steers, but SF does not attenuate acute ruminal acidosis. This content is only available as a PDF. Author notes 2 The authors are grateful to R. L. Bell for animal support, K. Barsuhn, M. M. Johnson, A. R. Cazers, J. L. Nappier, and G. A. Hoffman for laboratory support, V. P. Marshall for fermentation work, W. J. Smolenski for data capture, K. J. Dame for data handling, and L. Munyakazi for statistical support. 4 Present address: A. L. Laboratories, One Executive Dr., Fort Lee, NJ 07024. 5 Dept. of Anim. Sci. and Poult. Sci., North Carolina State Univ., Raleigh 27695. Copyright © 1995 by American Society of Animal Science

Journal

Journal of Animal Science – Oxford University Press

Published: Feb 1, 1995

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