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Arterial ChemoreceptorsSystemic Inhibition of the Na+/H+ Exchanger Type 3 in Intact Rats Activates Brainstem Respiratory Regions

Arterial Chemoreceptors: Systemic Inhibition of the Na+/H+ Exchanger Type 3 in Intact Rats... [Selective inhibition of the Na+/H+ exchanger type 3 (NHE3) increases the firing rate of brainstem ventrolateral CO2/H+ sensitive neurons, resembling the responses evoked by hypercapnic stimuli. In anesthetized animals, NHE3 inhibition has also been shown to stimulate the central chemosensitive drive. We aimed to analyze the respiratory-related brainstem regions affected by NHE3 inhibition in anaesthetized spontaneously-breathing rats with intact peripheral afferents. For that, c-Fos immunopositive cells were counted along the brainstem in rats intravenously infused with the selective NHE3 inhibitor AVE1599. A rostral extension of the ventral respiratory column which includes the pre-Bötzinger complex was activated by the NHE3 inhibitor. In addition, the number of c-Fos positive cells resulted significantly increased in the most rostral extension of the retrotrapezoid nucleus/parapyramidal region. In the pons, the intravenous infusion of AVE1599 activated the lateral parabrachial and Kölliker-Fuse nuclei. Thus, selective NHE3 inhibition in anaesthetized rats activates the respiratory network and evokes a pattern of c-Fos expressing cells similar to that induced by hypercapnia.] http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png

Arterial ChemoreceptorsSystemic Inhibition of the Na+/H+ Exchanger Type 3 in Intact Rats Activates Brainstem Respiratory Regions

Part of the Advances in Experimental Medicine and Biology Book Series (volume 648)
Editors: Gonzalez, Constancio; Nurse, Colin A.; Peers, Chris
Pasaro, R.; Ribas-Salgueiro, J.L.; Matarredona, E.R.; Sarmiento, M.; Ribas, J.
Arterial Chemoreceptors — Jan 1, 2009
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References (24)

Publisher
Springer Netherlands
Copyright
© Springer Netherlands 2009
ISBN
978-90-481-2258-5
Pages
395–401
DOI
10.1007/978-90-481-2259-2_45
Publisher site
See Chapter on Publisher Site

Abstract

[Selective inhibition of the Na+/H+ exchanger type 3 (NHE3) increases the firing rate of brainstem ventrolateral CO2/H+ sensitive neurons, resembling the responses evoked by hypercapnic stimuli. In anesthetized animals, NHE3 inhibition has also been shown to stimulate the central chemosensitive drive. We aimed to analyze the respiratory-related brainstem regions affected by NHE3 inhibition in anaesthetized spontaneously-breathing rats with intact peripheral afferents. For that, c-Fos immunopositive cells were counted along the brainstem in rats intravenously infused with the selective NHE3 inhibitor AVE1599. A rostral extension of the ventral respiratory column which includes the pre-Bötzinger complex was activated by the NHE3 inhibitor. In addition, the number of c-Fos positive cells resulted significantly increased in the most rostral extension of the retrotrapezoid nucleus/parapyramidal region. In the pons, the intravenous infusion of AVE1599 activated the lateral parabrachial and Kölliker-Fuse nuclei. Thus, selective NHE3 inhibition in anaesthetized rats activates the respiratory network and evokes a pattern of c-Fos expressing cells similar to that induced by hypercapnia.]

Published: Jan 1, 2009

Keywords: Central chemoreception; c-Fos immunohistochemistry; Pre-Bötzinger complex; Ventral respiratory column; Retrotrapezoid nucleus; Parapyramidal region; Lateral parabrachial nucleus; Kölliker-Fuse nucleus; Ventral respiratory group

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