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- Publisher
- Oxford University Press
- Copyright
- © 1981 by The Association of the Journal of Neuropathology and Experimental Neurology Inc.
- ISSN
- 0022-3069
- eISSN
- 1554-6578
- DOI
- 10.1097/00005072-198103000-00007
- Publisher site
- See Article on Publisher Site
Abstract
Abstract The sciatic/tibial/plantar nerve complex of normal aged rats displays striking morphological changes that are most pronounced distally. Nerve fiber abnormalities include: (a) large numbers of axonal glycogenosomes, mitochondria, dense membranous bodies, and decorated particles; (b) adaxonal Schwann cell processes sequestering portions of axoplasm; (c) swollen demyelinated and remyelinated axons, some encircled by supernumerary cellular processes; and (d) collagen pockets, denervated Schwann cell columns, and empty basal laminae. Abnormalities a and b were encountered with increasing frequency on descent through the tibial and plantar nerves. Abnormalities b, c, and d were found in lateral and medial plantar nerves, where they were associated with an enlarged endoneurial space. Found in animals kept in cages with smooth or wire-mesh floors, the incidence of these changes increased with advancing age. They are attributed to trauma and ischemia from chronic pressure on the plantar nerve. This content is only available as a PDF. © 1981 by The Association of the Journal of Neuropathology and Experimental Neurology Inc.
Journal
Journal of Neuropathology & Experimental Neurology – Oxford University Press
Published: Mar 1, 1981