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Morphological Investigation of Human Breast Cancer

Morphological Investigation of Human Breast Cancer Summary Twenty-two human breast cancers and two benign breast tumors were studied in the electron microscope. Human breast tumors were found to retain certain characteristics of their tissue of origin. There was some ductal differentiation in all these tumors. Unlike normal epithelial cells of the mammary gland, tumor cells frequently showed intracytoplasmic ductules and numerous cytoplasmic microfibrils identified as tonofibrils. These two cytological features were considered pathognomonic for cancer cells. The significance and nature of the nuclear “inclusions” and of some cytoplasmic structures described are unknown. No structures resembling any known infectious or oncogenic viruses were observed in the human breast material examined. 2 This communication is a tribute to the memory of Hugh F. Hare, M.D., of the Southern California Cancer Center, whose energy and farsightedness led to the formation of the Research Department. This content is only available as a PDF. Author notes 3 Albert Soiland Cancer Foundation Fellow. 4 We acknowledge the valuable cooperation of our surgical colleagues, James F. Nolan, M.D., William J. Oneal, M.D., Julian M. Sether, M.D., of the Los Angeles Tumor Institute, and the attending surgical staff of The California Hospital. We thank Warren L. Bostick, M.D., Dean, College of Medicine, University of California, Irvine, for reviewing this manuscript. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png JNCI: Journal of the National Cancer Institute Oxford University Press

Morphological Investigation of Human Breast Cancer

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Publisher
Oxford University Press
ISSN
0027-8874
eISSN
1460-2105
DOI
10.1093/jnci/40.2.195
Publisher site
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Abstract

Summary Twenty-two human breast cancers and two benign breast tumors were studied in the electron microscope. Human breast tumors were found to retain certain characteristics of their tissue of origin. There was some ductal differentiation in all these tumors. Unlike normal epithelial cells of the mammary gland, tumor cells frequently showed intracytoplasmic ductules and numerous cytoplasmic microfibrils identified as tonofibrils. These two cytological features were considered pathognomonic for cancer cells. The significance and nature of the nuclear “inclusions” and of some cytoplasmic structures described are unknown. No structures resembling any known infectious or oncogenic viruses were observed in the human breast material examined. 2 This communication is a tribute to the memory of Hugh F. Hare, M.D., of the Southern California Cancer Center, whose energy and farsightedness led to the formation of the Research Department. This content is only available as a PDF. Author notes 3 Albert Soiland Cancer Foundation Fellow. 4 We acknowledge the valuable cooperation of our surgical colleagues, James F. Nolan, M.D., William J. Oneal, M.D., Julian M. Sether, M.D., of the Los Angeles Tumor Institute, and the attending surgical staff of The California Hospital. We thank Warren L. Bostick, M.D., Dean, College of Medicine, University of California, Irvine, for reviewing this manuscript.

Journal

JNCI: Journal of the National Cancer Institute – Oxford University Press

Published: Feb 1, 1968

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