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References (94)
-
Tomohiko Fukuda, Ka Chen, Xiaohua Shi, Chuanyue Wu (2003)
PINCH-1 Is an Obligate Partner of Integrin-linked Kinase (ILK) Functioning in Cell Shape Modulation, Motility, and Survival*Journal of Biological Chemistry, 278
-
D. Crouch, V. Fincham, M. Frame (1996)
Targeted proteolysis of the focal adhesion kinase pp125 FAK during c-MYC-induced apoptosis is suppressed by integrin signalling.Oncogene, 12 12
-
T. Miyazaki, Min Shen, D. Fujikura, N. Tosa, Hyung-Ryong Kim, S. Kon, T. Uede, John Reed (2004)
Functional Role of Death-associated Protein 3 (DAP3) in Anoikis*Journal of Biological Chemistry, 279
-
S. Nikolopoulos, C. Turner (2002)
Molecular Dissection of Actopaxin-Integrin-linked Kinase-Paxillin Interactions and Their Role in Subcellular Localization*The Journal of Biological Chemistry, 277
-
H. Puthalakath, A. Villunger, L. O’Reilly, J. Beaumont, L. Coultas, R. Cheney, D. Huang, A. Strasser (2001)
Bmf: A Proapoptotic BH3-Only Protein Regulated by Interaction with the Myosin V Actin Motor Complex, Activated by AnoikisScience, 293
-
S. Kook, S. Shim, S. Choi, J. Ahnn, J. Kim, S. Eom, Y. Jung, S. Paik, W. Song (2000)
Caspase-mediated cleavage of p130cas in etoposide-induced apoptotic Rat-1 cells.Molecular biology of the cell, 11 3
-
A. Valentijn, A. Gilmore (2004)
Translocation of Full-length Bid to Mitochondria during Anoikis*Journal of Biological Chemistry, 279
-
Tzu-Ling Cheng, M. Symons, T. Jou (2004)
Regulation of anoikis by Cdc42 and Rac1.Experimental cell research, 295 2
-
Y. Jan, M. Matter, J. Pai, Yen-Liang Chen, J. Pilch, M. Komatsu, E. Ong, M. Fukuda, E. Ruoslahti (2004)
A Mitochondrial Protein, Bit1, Mediates Apoptosis Regulated by Integrins and Groucho/TLE CorepressorsCell, 116
-
S. Janes, F. Watt (2004)
Switch from αvβ5 to αvβ6 integrin expression protects squamous cell carcinomas from anoikisThe Journal of Cell Biology, 166
-
M. Reginato, Kenna Mills, J. Paulus, Danielle Lynch, D. Sgroi, Jayanta Debnath, S. Muthuswamy, J. Brugge (2003)
Integrins and EGFR coordinately regulate the pro-apoptotic protein Bim to prevent anoikisNature Cell Biology, 5
-
M. Rytömaa, L. Martins, J. Downward (1999)
Involvement of FADD and caspase-8 signalling in detachment-induced apoptosisCurrent Biology, 9
-
G. Salvesen, J. Abrams (2004)
Caspase activation – stepping on the gas or releasing the brakes? Lessons from humans and fliesOncogene, 23
-
H. Hsu, Jianing Huang, H. Shu, V. Baichwal, D. Goeddel (1996)
TNF-dependent recruitment of the protein kinase RIP to the TNF receptor-1 signaling complex.Immunity, 4 4
-
E. Werner, Z. Werb (2002)
Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPasesThe Journal of Cell Biology, 158
-
M. Pozo, W. Kiosses, Nazilla Alderson, N. Meller, K. Hahn, M. Schwartz (2002)
Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDINature Cell Biology, 4
-
S. Frisch (1999)
Evidence for a function of death-receptor-related, death-domain-containing proteins in anoikisCurrent Biology, 9
-
D. Altieri (2001)
The molecular basis and potential role of survivin in cancer diagnosis and therapy.Trends in molecular medicine, 7 12
-
M. Kroemker, A. Rüdiger, B. Jockusch, M. Rüdiger (1994)
Intramolecular interactions in vinculin control α‐actinin binding to the vinculin headFEBS Letters, 355
-
K. Boatright, G. Salvesen (2003)
Mechanisms of caspase activation.Current opinion in cell biology, 15 6
-
D. Stupack, D. Cheresh (2002)
Get a ligand, get a life: integrins, signaling and cell survivalJournal of Cell Science, 115
-
M. Hill, Jianhua Feng, B. Hemmings (2002)
Identification of a Plasma Membrane Raft-Associated PKB Ser473 Kinase Activity that Is Distinct from ILK and PDK1Current Biology, 12
-
K. Nicholson, N. Anderson (2002)
The protein kinase B/Akt signalling pathway in human malignancy.Cellular signalling, 14 5
-
S. Abbi, Guan Jl (2002)
Focal adhesion kinase: protein interactions and cellular functions.Histology and histopathology, 17 4
-
N. Danial, S. Korsmeyer (2004)
Cell death: critical control points.Cell, 116 2
-
Tomohiko Fukuda, Lida Guo, Xiaohua Shi, Chuanyue Wu (2003)
CH-ILKBP regulates cell survival by facilitating the membrane translocation of protein kinase B/AktThe Journal of Cell Biology, 160
-
Stuart Martin, K. Vuori (2004)
Regulation of Bcl-2 proteins during anoikis and amorphosis.Biochimica et biophysica acta, 1692 2-3
-
Robert Johnson, S. Craig (1995)
F-actin binding site masked by the intramolecular association of vinculin head and tail domainsNature, 373
-
Jerry Adams, S. Cory (2002)
Apoptosomes: engines for caspase activation.Current opinion in cell biology, 14 6
-
C. Widmann, S. Gibson, G. Johnson (1998)
Caspase-dependent Cleavage of Signaling Proteins during ApoptosisThe Journal of Biological Chemistry, 273
-
Lin Wei, Yu Yang, Xin Zhang, Qiang Yu (2002)
Anchorage‐independent phosphorylation of p130Cas protects lung adenocarcinoma cells from anoikisJournal of Cellular Biochemistry, 87
-
Lin Wei, Yu Yang, Xing Zhang, Qiang Yu (2004)
Cleavage of p130Cas in anoikisJournal of Cellular Biochemistry, 91
-
M. Oren (2003)
Decision making by p53: life, death and cancerCell Death and Differentiation, 10
-
S. Nikolopoulos, C. Turner (2000)
Actopaxin, a New Focal Adhesion Protein That Binds Paxillin Ld Motifs and Actin and Regulates Cell AdhesionThe Journal of Cell Biology, 151
-
S. Frisch, Hunter Francis (1994)
Disruption of epithelial cell-matrix interactions induces apoptosisThe Journal of Cell Biology, 124
-
G Dufour, MJ Demers, D Gagne, AB Dydensborg, IC Teller, V Bouchard, I Degongre, JF Beaulieu, JQ Cheng, N Fujita, T Tsuruo, K Vallee, PH Vachon (2004)
Human intestinal epithelial cell survival and anoikis: Differentiation state-distinct regulation and roles of protein kinase B/Akt isoformsJ Biol Chem, 279
-
C Widmann, S Gibson, GL Johnson (1998)
Caspase-dependent cleavage of signaling proteins during apoptosis. A turn-off mechanism for anti-apoptotic signalsJ Biol Chem, 273
-
S. Shim, S. Kook, J. Kim, W. Song (2001)
Degradation of focal adhesion proteins paxillin and p130cas by caspases or calpains in apoptotic rat-1 and L929 cells.Biochemical and biophysical research communications, 286 3
-
Yigong Shi (2004)
Caspase Activation Revisiting the Induced Proximity ModelCell, 117
-
M. Matter, E. Ruoslahti (2001)
A Signaling Pathway from the α5β1 and αvβ3 Integrins That Elevatesbcl-2 Transcription*The Journal of Biological Chemistry, 276
-
Z Zhang, K Vuori, JC Reed, E Ruoslahti (1995)
The α5β1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expressionProceedings Of The PNAS Of The United States Of America, 92
-
Yigong Shi (2002)
Mechanisms of caspase activation and inhibition during apoptosis.Molecular cell, 9 3
-
R. Pankov, E. Cukierman, K. Clark, Kazue Matsumoto, Cornelia Hahn, B. Poulin, Kenneth Yamada (2003)
Specific β1 Integrin Site Selectively Regulates Akt/Protein Kinase B Signaling via Local Activation of Protein Phosphatase 2A*The Journal of Biological Chemistry, 278
-
Wook Kim, S. Kook, Dae Kim, C. Teodorof, W. Song (2004)
The 31-kDa Caspase-generated Cleavage Product of p130cas Functions as a Transcriptional Repressor of E2A in Apoptotic Cells*Journal of Biological Chemistry, 279
-
J. Grossmann (2002)
Molecular mechanisms of “detachment-induced apoptosis—Anoikis”Apoptosis, 7
-
A Schulze, K Lehmann, HBJ Jefferies, M McMahon, J Downward (2001)
Analysis of the transcriptional program induced by Raf in epithelial cellsGenes Dev, 15
-
M. Marani, D. Hancock, R. Lopes, T. Tenev, J. Downward, N. Lemoine (2004)
Role of Bim in the survival pathway induced by Raf in epithelial cellsOncogene, 23
-
David Tumbarello, Michael Brown, C. Turner (2002)
The paxillin LD motifsFEBS Letters, 513
-
B. Stanger, P. Leder, Tae Lee, E. Kim, B. Seed (1995)
RIP: A novel protein containing a death domain that interacts with Fas/APO-1 (CD95) in yeast and causes cell deathCell, 81
-
G. O'Neill, E. Golemis (2001)
Proteolysis of the Docking Protein HEF1 and Implications for Focal Adhesion DynamicsMolecular and Cellular Biology, 21
-
M. Fornaro, J. Plescia, S. Chheang, G. Tallini, Yong-ming Zhu, Michael King, D. Altieri, L. Languino (2003)
Fibronectin Protects Prostate Cancer Cells from Tumor Necrosis Factor-α-induced Apoptosis via the AKT/Survivin Pathway*Journal of Biological Chemistry, 278
-
S. Cory, Jerry Adams (2002)
The Bcl2 family: regulators of the cellular life-or-death switchNature Reviews Cancer, 2
-
Tony Truong, Guizhen Sun, Michael Doorly, Jean Wang, M. Schwartz (2003)
Modulation of DNA damage-induced apoptosis by cell adhesion is independently mediated by p53 and c-AblProceedings of the National Academy of Sciences of the United States of America, 100
-
Robert Johnson, Susan Craig (1994)
An intramolecular association between the head and tail domains of vinculin modulates talin binding.The Journal of biological chemistry, 269 17
-
R. Juliano (2002)
Signal transduction by cell adhesion receptors and the cytoskeleton: functions of integrins, cadherins, selectins, and immunoglobulin-superfamily members.Annual review of pharmacology and toxicology, 42
-
M. Subauste, O. Pertz, E. Adamson, C. Turner, Sachiko Junger, K. Hahn (2004)
Vinculin modulation of paxillin–FAK interactions regulates ERK to control survival and motilityThe Journal of Cell Biology, 165
-
MA Schwartz (2001)
2553J Cell Sci, 114
-
F. Giancotti, G. Tarone (2003)
Positional control of cell fate through joint integrin/receptor protein kinase signaling.Annual review of cell and developmental biology, 19
-
Jean Lewis, Tony Truong, M. Schwartz (2002)
Integrins regulate the apoptotic response to DNA damage through modulation of p53Proceedings of the National Academy of Sciences of the United States of America, 99
-
Y. Tu, Yao Huang, Yongjun Zhang, Yun Hua, Chuanyue Wu (2001)
A New Focal Adhesion Protein That Interacts with Integrin-Linked Kinase and Regulates Cell Adhesion and SpreadingThe Journal of Cell Biology, 153
-
S. Cory, D. Huang, Jerry Adams (2003)
The Bcl-2 family: roles in cell survival and oncogenesisOncogene, 22
-
N. Ozören, W. El-Deiry (2003)
Cell surface Death Receptor signaling in normal and cancer cells.Seminars in cancer biology, 13 2
-
M. Rytömaa, K. Lehmann, J. Downward (2000)
Matrix detachment induces caspase-dependent cytochrome c release from mitochondria: inhibition by PKB/Akt but not Raf signallingOncogene, 19
-
M. Gall, J. Chambard, J. Breittmayer, D. Grall, J. Pouysségur, E. Obberghen-Schilling (2000)
The p42/p44 MAP kinase pathway prevents apoptosis induced by anchorage and serum removal.Molecular biology of the cell, 11 3
-
J. Coll, A. Ben-Ze'ev, R. Ezzell, J. Fernandez, H. Baribault, R. Oshima, E. Adamson (1995)
Targeted disruption of vinculin genes in F9 and embryonic stem cells changes cell morphology, adhesion, and locomotion.Proceedings of the National Academy of Sciences of the United States of America, 92 20
-
A Schulze (2001)
981Genes Dev, 15
-
E. Kurenova, Li‐hui Xu, Xihui Yang, A. Baldwin, R. Craven, S. Hanks, Zheng-Gang Liu, W. Cance (2004)
Focal Adhesion Kinase Suppresses Apoptosis by Binding to the Death Domain of Receptor-Interacting ProteinMolecular and Cellular Biology, 24
-
Z. Zhang, K. Vuori, John Reed, E. Ruoslahti (1995)
The alpha 5 beta 1 integrin supports survival of cells on fibronectin and up-regulates Bcl-2 expression.Proceedings of the National Academy of Sciences of the United States of America, 92 13
-
S. Biswas, L. Greene (2002)
Nerve Growth Factor (NGF) Down-regulates the Bcl-2 Homology 3 (BH3) Domain-only Protein Bim and Suppresses Its Proapoptotic Activity by Phosphorylation*The Journal of Biological Chemistry, 277
-
A. Schulze, K. Lehmann, Harold Jefferies, M. McMahon, J. Downward (2001)
Analysis of the transcriptional program induced by Raf in epithelial cellsNature Genetics, 27 Suppl 1
-
LB Eckert, GA Repasky, AS Ulku, A McFall, H Zhou, CI Sartor, CJ Der (2004)
Involvement of ras activation in human breast cancer cell signaling, invasion, and anoikisCancer Res, 64
-
Pengbo Wang, A. Gilmore, C. Streuli (2004)
Bim Is an Apoptosis Sensor That Responds to Loss of Survival Signals Delivered by Epidermal Growth Factor but Not Those Provided by Integrins*Journal of Biological Chemistry, 279
-
M. Pozo, L. Price, Nazilla Alderson, X. Ren, M. Schwartz (2000)
Adhesion to the extracellular matrix regulates the coupling of the small GTPase Rac to its effector PAKThe EMBO Journal, 19
-
R. Ley, Katherine Ewings, K. Hadfield, E. Howes, K. Balmanno, S. Cook (2004)
Extracellular Signal-regulated Kinases 1/2 Are Serum-stimulated “BimEL Kinases” That Bind to the BH3-only Protein BimEL Causing Its Phosphorylation and Turnover*Journal of Biological Chemistry, 279
-
Ian Zachary (1997)
Focal adhesion kinase.The international journal of biochemistry & cell biology, 29 7
-
V. Weaver, S. Lelièvre, J. Lakins, M. Chrenek, Jonathan Jones, F. Giancotti, Z. Werb, M. Bissell (2002)
beta4 integrin-dependent formation of polarized three-dimensional architecture confers resistance to apoptosis in normal and malignant mammary epithelium.Cancer cell, 2 3
-
Sirith Douma, Theo Laar, J. Zevenhoven, R. Meuwissen, E. Garderen, D. Peeper (2004)
Suppression of anoikis and induction of metastasis by the neurotrophic receptor TrkBNature, 430
-
Pengbo Wang, A. Valentijn, A. Gilmore, C. Streuli (2003)
Early Events in the Anoikis Program Occur in the Absence of Caspase Activation*Journal of Biological Chemistry, 278
-
A. Valentijn, A. Metcalfe, Jane Kott, C. Streuli, A. Gilmore (2003)
Spatial and temporal changes in Bax subcellular localization during anoikisThe Journal of Cell Biology, 162
-
B. Vogelstein, D. Lane, A. Levine (2000)
Surfing the p53 networkNature, 408
-
A. Gilmore, A. Metcalfe, L. Romer, C. Streuli (2000)
Integrin-Mediated Survival Signals Regulate the Apoptotic Function of Bax through Its Conformation and Subcellular LocalizationThe Journal of Cell Biology, 149
-
H. Puthalakath, D. Huang, L. O’Reilly, S. King, A. Strasser (1999)
The proapoptotic activity of the Bcl-2 family member Bim is regulated by interaction with the dynein motor complex.Molecular cell, 3 3
-
Salvatore Coniglio, T. Jou, M. Symons (2001)
Rac1 Protects Epithelial Cells against Anoikis*The Journal of Biological Chemistry, 276
-
(2001)
Integrin-linked kinase (ILK) and its interactors: A new paradigm for the coupling of extracellular matrix to actin cytoskeleton and signaling complexes -
S. Alahari, P. Reddig, R. Juliano (2002)
Biological aspects of signal transduction by cell adhesion receptors.International review of cytology, 220
-
L. Eckert, G. Repasky, Aylin Ülkü, Aidan McFall, Hong Zhou, Carolyn Sartor, C. Der (2004)
Signaling , Invasion , and Anoikis Involvement of Ras Activation in Human Breast Cancer Cell -
G. Dufour, M. Demers, D. Gagné, A. Dydensborg, I. Teller, V. Bouchard, I. Degongre, J. Beaulieu, J. Cheng, N. Fujita, T. Tsuruo, K. Vallée, P. Vachon (2004)
Human Intestinal Epithelial Cell Survival and AnoikisJournal of Biological Chemistry, 279
-
A. Troussard, Nasrin Mawji, C. Ong, A. Mui, R. St-Arnaud, S. Dedhar (2003)
Conditional Knock-out of Integrin-linked Kinase Demonstrates an Essential Role in Protein Kinase B/Akt Activation*Journal of Biological Chemistry, 278
-
M. Schwartz, R. Assoian (2001)
Integrins and cell proliferation: regulation of cyclin-dependent kinases via cytoplasmic signaling pathways.Journal of cell science, 114 Pt 14
-
A. Howe, A. Aplin, R. Juliano (2002)
Anchorage-dependent ERK signaling--mechanisms and consequences.Current opinion in genetics & development, 12 1
-
M. Pozo, W. Kiosses, Nazilla Alderson, N. Meller, K. Hahn, M. Schwartz (2002)
Integrins regulate GTP-Rac localized effector interactions through dissociation of Rho-GDI.Nature Reviews Molecular Cell Biology, 3
-
D. Green, G. Kroemer (2004)
The Pathophysiology of Mitochondrial Cell DeathScience, 305
-
K. Burridge, P. Mangeat (1984)
An interaction between vinculin and talinNature, 308
-
S. Law, G. O'Neill, S. Fashena, M. Einarson, E. Golemis (2000)
The Docking Protein HEF1 Is an Apoptotic Mediator at Focal Adhesion SitesMolecular and Cellular Biology, 20
- Publisher
- Springer Journals
- Copyright
- Copyright © 2005 by Springer Science + Business Media, Inc.
- Subject
- Medicine & Public Health; Cancer Research; Oncology
- ISSN
- 0167-7659
- eISSN
- 1573-7233
- DOI
- 10.1007/s10555-005-5134-3
- pmid
- 16258730
- Publisher site
- See Article on Publisher Site
Abstract
Cell to matrix adhesion regulates cellular homeostasis in multiple ways. Integrin attachment to the extracellular matrix mediates this regulation through direct and indirect connections to the actin cytoskeleton, growth factor receptors, and intracellular signal transduction cascades. Disruption of this connection to the extracellular matrix has deleterious effects on cell survival. It leads to a specific type of apoptosis known as anoikis in most non-transformed cell types. Anchorage independent growth is a critical step in the tumorigenic transformation of cells. Thus, breaching the anoikis barrier disrupts the cell's defenses against transformation. This review examines recent investigations into the molecular mechanisms of anoikis to illustrate current understanding of this important process.
Journal
Cancer and Metastasis Reviews – Springer Journals
Published: Jan 1, 2005