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Interleukin-12 and the regulation of innate resistance and adaptive immunity

Interleukin-12 and the regulation of innate resistance and adaptive immunity Interleukin-12 (IL-12) is a heterodimeric pro-inflammatory cytokine that regulates T-cell and natural killer-cell responses, induces the production of interferon-γ (IFN-γ), favours the differentiation of T helper 1 (TH1) cells and is an important link between innate resistance and adaptive immunity. Although phagocytes were reported originally to be the main cell types that produce IL-12, subsets of dendritic cells (DCs) are the first producers of IL-12 in response to pathogens during infections. The differential production of IL-12 by DC subsets in response to various pathogens is dependent on differences in the regulation of expression of the gene encoding IL-12, patterns of Toll-like receptor (TLR) expression, and cross-regulation between the different subsets, involving cytokines such as IL-10 and type I IFN. Maturation of CD4+ and CD8+ T cells into type-1 cytokine-producing cells is differentially regulated, indicating the different relative roles of IL-12 and other factors in favouring maturation of the two cell types. Recently, it has become evident, however, that TH1 responses might take place in the absence of IL-12 and that IL-12 might be only one of the members of a family of heterodimeric cytokines, also including IL-23 and IL-27, that are involved in the regulation of TH1 responses. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Reviews Immunology Springer Journals

Interleukin-12 and the regulation of innate resistance and adaptive immunity

Trinchieri, Giorgio
Nature Reviews Immunology , Volume 3 (2) – Feb 1, 2003
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References (151)

Publisher
Springer Journals
Copyright
Copyright © 2003 by Nature Publishing Group
Subject
Biomedicine; Biomedicine, general; Immunology
ISSN
1474-1733
eISSN
1474-1741
DOI
10.1038/nri1001
Publisher site
See Article on Publisher Site

Abstract

Interleukin-12 (IL-12) is a heterodimeric pro-inflammatory cytokine that regulates T-cell and natural killer-cell responses, induces the production of interferon-γ (IFN-γ), favours the differentiation of T helper 1 (TH1) cells and is an important link between innate resistance and adaptive immunity. Although phagocytes were reported originally to be the main cell types that produce IL-12, subsets of dendritic cells (DCs) are the first producers of IL-12 in response to pathogens during infections. The differential production of IL-12 by DC subsets in response to various pathogens is dependent on differences in the regulation of expression of the gene encoding IL-12, patterns of Toll-like receptor (TLR) expression, and cross-regulation between the different subsets, involving cytokines such as IL-10 and type I IFN. Maturation of CD4+ and CD8+ T cells into type-1 cytokine-producing cells is differentially regulated, indicating the different relative roles of IL-12 and other factors in favouring maturation of the two cell types. Recently, it has become evident, however, that TH1 responses might take place in the absence of IL-12 and that IL-12 might be only one of the members of a family of heterodimeric cytokines, also including IL-23 and IL-27, that are involved in the regulation of TH1 responses.

Journal

Nature Reviews Immunology – Springer Journals

Published: Feb 1, 2003

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