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Dentin structure in familial hypophosphatemic rickets: benefits of vitamin D and phosphate treatment

Dentin structure in familial hypophosphatemic rickets: benefits of vitamin D and phosphate treatment Objective: To evaluate the outcome of 1‐(OH) vitamin D and oral phosphate treatment on dentin structure in patients with familial hypophosphatemic rickets, and expression of SIBLINGs (a family of non‐collagenous proteins involved in dentinogenesis) and osteocalcin. Patients and methods: Seven patients with familial hypophosphatemic rickets (age 3–16 years) were studied before or during treatment. Deciduous and permanent teeth were prepared for scanning electron microscopy (SEM) analysis and immunohistochemistry. Results: Untreated or inadequately treated patients had necrotic teeth with impaired dentin mineralization including unmerged calcospherites and accumulation of non‐collagenous proteins in wide interglobular spaces. Most of the primary incisors analyzed displayed fissures linking enamel subsurface to pulp horn. These elements may explain the bacterial penetration and dental abscesses despite the absence of carious lesions. Well‐treated patients had healthy teeth with good dentin mineralization and little evidence of calcospherites. Conclusion: Treatment of hypophosphatemic children with 1‐(OH) vitamin D and oral phosphate insures good dentin development and mineralization, and prevents clinical anomalies such as the dental necrosis classically associated with the disease. Starting treatment during early childhood and good adherence to the therapy are mandatory to observe these beneficial effects. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Oral Diseases Wiley

Dentin structure in familial hypophosphatemic rickets: benefits of vitamin D and phosphate treatment

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References (33)

Publisher
Wiley
Copyright
Copyright © 2007 Wiley Subscription Services, Inc., A Wiley Company
ISSN
1354-523X
eISSN
1601-0825
DOI
10.1111/j.1601-0825.2006.01326.x
pmid
17714351
Publisher site
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Abstract

Objective: To evaluate the outcome of 1‐(OH) vitamin D and oral phosphate treatment on dentin structure in patients with familial hypophosphatemic rickets, and expression of SIBLINGs (a family of non‐collagenous proteins involved in dentinogenesis) and osteocalcin. Patients and methods: Seven patients with familial hypophosphatemic rickets (age 3–16 years) were studied before or during treatment. Deciduous and permanent teeth were prepared for scanning electron microscopy (SEM) analysis and immunohistochemistry. Results: Untreated or inadequately treated patients had necrotic teeth with impaired dentin mineralization including unmerged calcospherites and accumulation of non‐collagenous proteins in wide interglobular spaces. Most of the primary incisors analyzed displayed fissures linking enamel subsurface to pulp horn. These elements may explain the bacterial penetration and dental abscesses despite the absence of carious lesions. Well‐treated patients had healthy teeth with good dentin mineralization and little evidence of calcospherites. Conclusion: Treatment of hypophosphatemic children with 1‐(OH) vitamin D and oral phosphate insures good dentin development and mineralization, and prevents clinical anomalies such as the dental necrosis classically associated with the disease. Starting treatment during early childhood and good adherence to the therapy are mandatory to observe these beneficial effects.

Journal

Oral Diseases – Wiley

Published: Sep 1, 2007

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