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Tumour-suppressor genes: evolving definitions in the genomic age

Tumour-suppressor genes: evolving definitions in the genomic age © 1997 Nature Publishing Group http://www.nature.com/naturegenetics ­ ­ . • news views Nramp2 mRNA, with dietary iron defi­ suffer from skin lesions reminiscent of inher­ export process. Similarly, the rat and another ciency bumpin5 up milNA levels of ited disorders of zinc deficiency-acroder­ mouse mutant (hgd) with normal intestinal Nramp2 in all tissues tested. An iron matitis enteropathica in humans and lethal iron uptake and iron export but defective response element (IRE) consensus sequence milk in mice. On the other hand, Nramp2 iron transport within the erythroblast may present within a potential stem loop in the may act as a redundant transporter of these enhance our understanding of intra-cellular 3' untranslated region may confer regula metals. Of the metals known to be trans­ iron transport. tion by an IRE-binding protein (IRE-BP) • ported by Nramp2, only copper is known to In mice, anaemia is in the genes, but what As a mutation in the Hfe results in inap­ have a mammalian uptake protein , of man? Iron-deficiency anaemia is generally propriately high iron uptake in iron-replete although its role in intestinal transport is believed to be environmental-a conse­ individuals, it will be interesting to deter unknown. IfNramp2 serves a http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Genetics Springer Journals

Tumour-suppressor genes: evolving definitions in the genomic age

Haber, Daniel; Harlow, Ed
Nature Genetics , Volume 16 (4) – Aug 1, 1997
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References (8)

Publisher
Springer Journals
Copyright
Copyright © 1997 by Nature Publishing Group
Subject
Biomedicine; Biomedicine, general; Human Genetics; Cancer Research; Agriculture; Gene Function; Animal Genetics and Genomics
ISSN
1061-4036
eISSN
1546-1718
DOI
10.1038/ng0897-320
Publisher site
See Article on Publisher Site

Abstract

© 1997 Nature Publishing Group http://www.nature.com/naturegenetics ­ ­ . • news views Nramp2 mRNA, with dietary iron defi­ suffer from skin lesions reminiscent of inher­ export process. Similarly, the rat and another ciency bumpin5 up milNA levels of ited disorders of zinc deficiency-acroder­ mouse mutant (hgd) with normal intestinal Nramp2 in all tissues tested. An iron matitis enteropathica in humans and lethal iron uptake and iron export but defective response element (IRE) consensus sequence milk in mice. On the other hand, Nramp2 iron transport within the erythroblast may present within a potential stem loop in the may act as a redundant transporter of these enhance our understanding of intra-cellular 3' untranslated region may confer regula metals. Of the metals known to be trans­ iron transport. tion by an IRE-binding protein (IRE-BP) • ported by Nramp2, only copper is known to In mice, anaemia is in the genes, but what As a mutation in the Hfe results in inap­ have a mammalian uptake protein , of man? Iron-deficiency anaemia is generally propriately high iron uptake in iron-replete although its role in intestinal transport is believed to be environmental-a conse­ individuals, it will be interesting to deter unknown. IfNramp2 serves a

Journal

Nature Genetics – Springer Journals

Published: Aug 1, 1997

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