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- Publisher
- Springer Journals
- Copyright
- Copyright © 2015 by Nature Publishing Group, a division of Macmillan Publishers Limited. All Rights Reserved.
- Subject
- Biomedicine; Biomedicine, general; Neurosciences; Behavioral Sciences; Biological Techniques; Neurobiology; Animal Genetics and Genomics
- ISSN
- 1097-6256
- eISSN
- 1546-1726
- DOI
- 10.1038/nn.3963
- Publisher site
- See Article on Publisher Site
Abstract
This study utilizes in vivo clonal lineage tracing of adult subependymal zone neural stem cells in mice to reveal frequent stem cells divisions and significant progeny expansion, thus allowing rapid clonal growth. The authors also show that neural stem cells lacked significant long-term self-renewal abilities which led to clonal exhaustion. Olfactory bulb neuronal diversity emerges at the population level, as single stem cells show restricted diversity in neuronal subtype production.
Journal
Nature Neuroscience – Springer Journals
Published: Mar 2, 2015