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Chemokine control of HIV-1 infection

Chemokine control of HIV-1 infection Chemokines are proinflammatory cytokines that attract and activate specific types of leukocyte 1 . There are two main chemokine families, based on the position of the first two cysteine residues: the CC and the CXC chemokines 1 . Chemokines mediate their effects through interactions with seven-transmembrane-spanning glyco-protein receptors coupled to a G-protein signalling pathway 1 . Chemokine receptors normally undergo a ligand-mediated homodimerization process, which is required for Ca2+ flux and chemotaxis 2 . Here we show that in the chemokine response it is possible for heterodimerization, rather than homodimerization, to occur between a mutant form of the CCR2 receptor (the CCR2V64I receptor), which helps to delay the development of AIDS in HIV-1-infected individuals, and the CCR5 or CXCR4 chemokine receptor, which are used by HIV to gain entry into cells. These results may explain why AIDS takes longer to develop in HIV-1-infected individuals carrying the CCR2V64I mutation 3 . http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Nature Springer Journals

Chemokine control of HIV-1 infection

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References (2)

Publisher
Springer Journals
Copyright
Copyright © 1999 by Macmillan Magazines Ltd.
Subject
Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
ISSN
0028-0836
eISSN
1476-4687
DOI
10.1038/23382
Publisher site
See Article on Publisher Site

Abstract

Chemokines are proinflammatory cytokines that attract and activate specific types of leukocyte 1 . There are two main chemokine families, based on the position of the first two cysteine residues: the CC and the CXC chemokines 1 . Chemokines mediate their effects through interactions with seven-transmembrane-spanning glyco-protein receptors coupled to a G-protein signalling pathway 1 . Chemokine receptors normally undergo a ligand-mediated homodimerization process, which is required for Ca2+ flux and chemotaxis 2 . Here we show that in the chemokine response it is possible for heterodimerization, rather than homodimerization, to occur between a mutant form of the CCR2 receptor (the CCR2V64I receptor), which helps to delay the development of AIDS in HIV-1-infected individuals, and the CCR5 or CXCR4 chemokine receptor, which are used by HIV to gain entry into cells. These results may explain why AIDS takes longer to develop in HIV-1-infected individuals carrying the CCR2V64I mutation 3 .

Journal

Nature – Springer Journals

Published: Aug 19, 1999

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