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References (45)
-
Shoji Harada, T. Okubo, Takako Nakamura, Chieko Fujii, Fumio Nomura, Susumu Higuchi, Mikihiro Tsutsumi (1999)
A novel polymorphism (-357 G/A) of the ALDH2 gene: linkage disequilibrium and an association with alcoholism.Alcoholism, clinical and experimental research, 23 6
-
M. Daly, J. Rioux, S. Schaffner, T. Hudson, E. Lander (2001)
High-resolution haplotype structure in the human genomeNature Genetics, 29
-
G. Kirov, Nigel Williams, Pak Sham, N. Craddock, M. Owen (2000)
Pooled genotyping of microsatellite markers in parent-offspring trios.Genome research, 10 1
-
J. Endicott, R. Spitzer (1978)
A diagnostic interview: the schedule for affective disorders and schizophrenia.Archives of general psychiatry, 35 7
-
N. Craddock, V. Khodel, P. Eerdewegh, T. Reich (1995)
Mathematical limits of multilocus models: the genetic transmission of bipolar disorder.American journal of human genetics, 57 3
-
M. Baron (2002)
Manic-depression genes and the new millennium: poised for discoveryMolecular Psychiatry, 7
-
(1994)
Diagnostic and statistical manual of mental disorders . WashingtonDC : American Psychiatric Association . BaronM . 2002 . Manic - depression genes and the newmillennium : Poised for discovery -
P. Sham, D. Curtis (1995)
Monte Carlo tests for associations between disease and alleles at highly polymorphic lociAnnals of Human Genetics, 59
-
G. Zubenko, B. Maher, H. Hughes, W. Zubenko, J. Stiffler, B. Kaplan, M. Marazita (2003)
Genome‐wide linkage survey for genetic loci that influence the development of depressive disorders in families with recurrent, early‐onset, major depressionAmerican Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 123B
-
N. Jacobsen, G. Elvidge, E. Franks, M. O’Donovan, N. Craddock, M. Owen (2001)
CUX2, a potential regulator of NCAM expression: genomic characterization and analysis as a positional candidate susceptibility gene for bipolar disorder.American journal of medical genetics, 105 3
-
G. Abecasis, W. Cookson (2000)
GOLD-Graphical Overview of Linkage DisequilibriumBioinformatics, 16 2
-
D. Curtis, G. Kalsi, J. Brynjólfsson, M. McInnis, J. O'Neill, C. Smyth, E. Moloney, P. Murphy, A. McQuillin, H. Pétursson, H. Gurling (2003)
Genome scan of pedigrees multiply affected with bipolar disorder provides further support for the presence of a susceptibility locus on chromosome 12q23‐q24, and suggests the presence of additional loci on 1p and 1qPsychiatric Genetics, 13
-
D. Goldstein (2001)
Islands of linkage disequilibriumNature Genetics, 29
-
S. Gabriel, S. Schaffner, Huy Nguyen, Jamie Moore, J. Roy, B. Blumenstiel, J. Higgins, M. Defelice, Amy Lochner, M. Faggart, S. Liu-Cordero, C. Rotimi, A. Adeyemo, R. Cooper, R. Ward, E. Lander, M. Daly, D. Altshuler (2002)
The Structure of Haplotype Blocks in the Human GenomeScience, 296
-
D. Blackwood, Lin He, Stewart Morris, A. McLean, C. Whitton, M. Thomson, Maura Walker, K. Woodburn, Cliff Sharp, Allan Wright,, Y. Shibasaki, D. Clair, David Poreous, Walter Muir (1996)
A locus for bipolar affective disorder on chromosome 4pNature Genetics, 12
-
A. Musacchio, T. Gibson, P. Rice, J. Thompson, M. Saraste (1993)
The PH domain: a common piece in the structural patchwork of signalling proteins.Trends in biochemical sciences, 18 9
-
J. Ekholm, T. Kieseppä, T. Hiekkalinna, T. Partonen, T. Paunio, M. Perola, J. Ekelund, J. Lönnqvist, Petra Pekkarinen-Ijäs, L. Peltonen (2003)
Evidence of susceptibility loci on 4q32 and 16p12 for bipolar disorder.Human molecular genetics, 12 15
-
J. Zhao, D. Curtis, P. Sham (1999)
Model-Free Analysis and Permutation Tests for Allelic AssociationsHuman Heredity, 50
-
N. Craddock, E. Dawson, Susan Burge, Liz Parfitt, Becky Mant, Queta Roberts, J. Daniels, M. Gill, P. McGuffin, J. Powell, M. Owen, M. Owen (1993)
The gene for Darier's disease maps to chromosome 12q23-q24.1.Human molecular genetics, 2 11
-
G. Johnson, L. Esposito, B. Barratt, Annabel Smith, J. Heward, G. Genova, H. Ueda, H. Cordell, I. Eaves, F. Dudbridge, R. Twells, F. Payne, Wil Hughes, S. Nutland, H. Stevens, Phill Carr, E. Tuomilehto-Wolf, J. Tuomilehto, S. Gough, D. Clayton, J. Todd (2001)
Haplotype tagging for the identification of common disease genesNature Genetics, 29
-
E. Green, G. Elvidge, N. Jacobsen, B. Glaser, I. Jones, M. O’Donovan, G. Kirov, M. Owen, N. Craddock (2005)
Localization of bipolar susceptibility locus by molecular genetic analysis of the chromosome 12q23-q24 region in two pedigrees with bipolar disorder and Darier's disease.The American journal of psychiatry, 162 1
-
M. Vawter, J. Hemperly, T. Hyde, S. Bachus, D. Vanderputten, Allyson Howard, H. Cannon-Spoor, M. McCoy, M. Webster, J. Kleinman, W. Freed (1998)
VASE-Containing N-CAM Isoforms Are Increased in the Hippocampus in Bipolar Disorder but Not SchizophreniaExperimental Neurology, 154
-
F. Ringpfeil, A. Raus, J. DiGiovanna, B. Korge, W. Harth, C. Mazzanti, J. Uitto, S. Bale, G. Richard (2001)
Darier disease – novel mutations in ATP2A2 and genotype–phenotype correlationExperimental Dermatology, 10
-
E. Dawson, E. Parfitt, Queta Roberts, J. Daniels, Lionel Lim, Pak Sham, M. Nöthen, P. Propping, M. Lanczik, Wolfgang Maier, Ulrike Reuner, Jean Weissenbach, Michael Gill, John Powell, P. McGuffin, M. Owen, N. Craddock, N. Craddock (1995)
Linkage studies of bipolar disorder in the region of the Darier's disease gene on chromosome 12q23-24.1.American journal of medical genetics, 60 2
-
H. Ewald, T. Flint, T. Kruse, O. Mors (2002)
A genome-wide scan shows significant linkage between bipolar disorder and chromosome 12q24.3 and suggestive linkage to chromosomes 1p22–21, 4p16, 6q14–22, 10q26 and 16p13.3Molecular Psychiatry, 7
-
J. Morissette, A. Villeneuve, Lise Bordeleau, Denis Rochette, C. Laberge, B. Gagné, C. Laprise, G. Bouchard, M. Plante, L. Gobeil, E. Shink, J. Weissenbach, N. Barden (1999)
Genome-wide search for linkage of bipolar affective disorders in a very large pedigree derived from a homogeneous population in quebec points to a locus of major effect on chromosome 12q23-q24.American journal of medical genetics, 88 5
-
T. Schulze, Yu-Sheng Chen, N. Akula, K. Hennessy, J. Badner, M. McInnis, J. DePaulo, J. Schumacher, S. Cichon, P. Propping, W. Maier, M. Rietschel, M. Nöthen, F. McMahon (2002)
Can long-range microsatellite data be used to predict short-range linkage disequilibrium?Human molecular genetics, 11 12
-
N. Craddock, M. Owen, S. Burge, Bobby Kurian, Phil Thomas, P. McGuffin (1994)
Familial Cosegregation of Major Affective Disorder and Darier's Disease (Keratosis Follicularis)British Journal of Psychiatry, 164
-
V. Abkevich, N. Camp, C. Hensel, C. Neff, Deanna Russell, Dana Hughes, Agnes Plenk, M. Lowry, R. Richards, C. Carter, G. Frech, S. Stone, K. Rowe, C. Chau, Kathleen Cortado, Angelene Hunt, Karanina Luce, G. O'Neil, J. Poarch, J. Potter, Gregg Poulsen, H. Saxton, Michelle Bernat-Sestak, Victor Thompson, A. Gutin, M. Skolnick, D. Shattuck, L. Cannon-Albright (2003)
Predisposition locus for major depression at chromosome 12q22-12q23.2.American journal of human genetics, 73 6
-
J. Rioux, M. Daly, M. Silverberg, K. Lindblad, H. Steinhart, Z. Cohen, T. Delmonte, Kerry Kocher, Katie Miller, Sheila Guschwan, E. Kulbokas, Sinead O'Leary, E. Winchester, K. Dewar, Todd Green, Valerie Stone, C. Chow, A. Cohen, Diane Langelier, Gilles Lapointe, D. Gaudet, J. Faith, Nancy Branco, S. Bull, R. McLeod, A. Griffiths, A. Bitton, G. Greenberg, E. Lander, K. Siminovitch, T. Hudson (2001)
Genetic variation in the 5q31 cytokine gene cluster confers susceptibility to Crohn diseaseNature Genetics, 29
-
Ian Jones, N. Jacobsen, E. Green, G. Elvidge, M. Owen, N. Craddock (2002)
Evidence for familial cosegregation of major affective disorder and genetic markers flanking the gene for Darier's diseaseMolecular Psychiatry, 7
-
N. Jacobsen, E. Franks, G. Elvidge, Ian Jones, F. McCandless, M. O’Donovan, M. Owen, N. Craddock (2001)
Exclusion of the Darier's disease gene, ATP2A2, as a common susceptibility gene for bipolar disorderMolecular Psychiatry, 6
-
S. Detera-Wadleigh (1999)
Chromosomes 12 and 16 workshop.American journal of medical genetics, 88 3
-
W. Ellerbroek (1971)
The Diagnostic InterviewJAMA, 217
-
N. Jacobsen, Ita Lyons, B. Hoogendoorn, S. Burge, Pui-Yan Kwok, M. O’Donovan, N. Craddock, M. Owen (1999)
ATP2A2 mutations in Darier's disease and their relationship to neuropsychiatric phenotypes.Human molecular genetics, 8 9
-
S. Quaggin, G. Heuvel, K. Golden, R. Bodmer, P. Igarashi (1996)
Primary Structure, Neural-specific Expression, and Chromosomal Localization of Cux-2, a Second Murine Homeobox Gene Related to Drosophila cut*The Journal of Biological Chemistry, 271
-
M. Baron (1994)
Seminars in Psychiatric GeneticsBMJ, 309
-
P. McGuffin, F. Rijsdijk, M. Andrew, P. Sham, R. Katz, A. Cardno (2003)
The heritability of bipolar affective disorder and the genetic relationship to unipolar depression.Archives of general psychiatry, 60 5
-
J. Potash, J Jr (2000)
Searching high and low: a review of the genetics of bipolar disorder.Bipolar disorders, 2 1
-
Q. Hu, Bethany Cool, Baiping Wang, M. Hearn, G. Martin (2002)
A candidate molecular mechanism for the association of an intronic polymorphism of FE65 with resistance to very late onset dementia of the Alzheimer type.Human molecular genetics, 11 4
-
J. Wing, T. Babor, T. Brugha, J. Burke, J. Cooper, R. Giel, A. Jablenski, D. Regier, N. Sartorius (1990)
SCAN. Schedules for Clinical Assessment in Neuropsychiatry.Archives of general psychiatry, 47 6
-
R. Spielman, R. McGinnis, Warren Ewenst (1993)
Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM).American journal of human genetics, 52 3
-
K. Kendler (1996)
Seminars in Psychiatric GeneticsAmerican Journal of Psychiatry, 153
-
A. Sakuntabhai, V. Ruiz-Perez, S. Carter, N. Jacobsen, S. Burge, S. Monk, Melanie Smith, C. Munro, M. O’Donovan, N. Craddock, R. Kucherlapati, J. Rees, M. Owen, G. Lathrop, A. Monaco, T. Strachan, A. Hovnanian (1999)
Mutations in ATP2A2, encoding a Ca2+ pump, cause Darier diseaseNature Genetics, 21
-
R. Bashir, C. Munro, S. Mason, A. Stephenson, J. Rees, T. Strachan (1993)
Localisation of a gene for Darier's disease.Human molecular genetics, 2 11
- Publisher
- Wiley
- Copyright
- Copyright © 2005 Wiley‐Liss, Inc., A Wiley Company
- ISSN
- 1552-4841
- eISSN
- 1552-485X
- DOI
- 10.1002/ajmg.b.30081
- pmid
- 15389760
- Publisher site
- See Article on Publisher Site
Abstract
Chromosome 12q23‐q24 has been implicated by several linkage studies as harboring a gene for bipolar affective disorder. We performed linkage disequilibrium (LD) mapping with 17 microsatellite markers across a 1.6 Mb‐wide segment forming the central part of our narrowest linkage region. A significant signal (P = 0.0016) was identified for one microsatellite marker in our UK Caucasian case‐control sample (347 cases, 374 controls). Genes, including regulatory elements, around this marker were screened for mutations and the LD structure of the region determined by genotyping 22 SNPs and insertion/deletion polymorphisms in 94 individuals. A set of 11 haplotype tagging (ht) SNPs was genotyped in our sample using a two‐stage procedure. Two SNPs (rs3847953 and rs933399) and an insertion/deletion with putative functional relevance (which are in high LD with each other and with the microsatellite marker) showed significant or nearly significant association with bipolar disorder after Bonferroni‐correction (reaching nominal P values from P = 0.002 to P = 0.005). In a sample of 110 UK Caucasian parent–offspring trios there was a trend for an over transmission in the same direction that failed to meet conventional levels of statistical significance. Our data provide evidence for association between bipolar mood disorder and markers on chromosome 12q23‐q24 but need replication in independent samples. © 2004 Wiley‐Liss, Inc.
Journal
American Journal of Medical Genetics part B – Wiley
Published: Jan 5, 2005
Keywords: bipolar affective disorder; chromosome 12; association; Darrier's disease; haplotype