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THE EFFECT OF FORMULATION ON THE CLINICAL RESPONSE TO TOPICAL FLUOCINOLONE ACETONIDE.

THE EFFECT OF FORMULATION ON THE CLINICAL RESPONSE TO TOPICAL FLUOCINOLONE ACETONIDE. THE EFFECT OF FORMULATION ON THE CLINICAL RESPONSE TO TOPICAL FLUOCINOLONE ACETONIDE. BENJAMIN PORTNOY. Manchester and Salford Hospital for Skin Diseases, Quay St., Manchester, 3. I N selecting the best bases for topical application of drugs, Williams (1964) has stressed the need for " much clinical study by many investigators over many years ". Penetration, defined by Goldsmith and Hellier (1954) as entry of a drug into the skin from a topically applied medicament, is likely to be different in normal and diseased skins. Kalz and Scott (1956) studied the therapeutic action of hydrocortisone in a variety of bases. They came to the conclusion that the differences they observed were not determined primarily by any specific infiuence of the bases on penetration, but rather depended on the compatibility of the base with the skin disease and its particular location. Jarrett (1961) has suggested that each type of skin disorder probably alters penetration in a different manner thus making a particular medicament from a particular vehicle more or less available to epidermal cells. In a different context, the particle size of the drug itself has been shown to exert a profound infiuence on therapeutic effect. Studies on griseofulvin (Atkinson et http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png British Journal of Dermatology Oxford University Press

THE EFFECT OF FORMULATION ON THE CLINICAL RESPONSE TO TOPICAL FLUOCINOLONE ACETONIDE.

PORTNOY, BENJAMIN
British Journal of Dermatology , Volume 77 (11): 3 – Nov 1, 1965
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References (9)

Publisher
Oxford University Press
Copyright
© 1965 British Association of Dermatologists
ISSN
0007-0963
eISSN
1365-2133
DOI
10.1111/j.1365-2133.1965.tb14579.x
Publisher site
See Article on Publisher Site

Abstract

THE EFFECT OF FORMULATION ON THE CLINICAL RESPONSE TO TOPICAL FLUOCINOLONE ACETONIDE. BENJAMIN PORTNOY. Manchester and Salford Hospital for Skin Diseases, Quay St., Manchester, 3. I N selecting the best bases for topical application of drugs, Williams (1964) has stressed the need for " much clinical study by many investigators over many years ". Penetration, defined by Goldsmith and Hellier (1954) as entry of a drug into the skin from a topically applied medicament, is likely to be different in normal and diseased skins. Kalz and Scott (1956) studied the therapeutic action of hydrocortisone in a variety of bases. They came to the conclusion that the differences they observed were not determined primarily by any specific infiuence of the bases on penetration, but rather depended on the compatibility of the base with the skin disease and its particular location. Jarrett (1961) has suggested that each type of skin disorder probably alters penetration in a different manner thus making a particular medicament from a particular vehicle more or less available to epidermal cells. In a different context, the particle size of the drug itself has been shown to exert a profound infiuence on therapeutic effect. Studies on griseofulvin (Atkinson et

Journal

British Journal of Dermatology – Oxford University Press

Published: Nov 1, 1965

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