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miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs Downloaded from genesdev.cshlp.org on November 4, 2021 - Published by Cold Spring Harbor Laboratory Press miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs 1,2 1 1 1 3 Zissimos Mourelatos, Jose´ e Dostie, Sergey Paushkin, Anup Sharma, Bernard Charroux, 1 4 4 1,5 Linda Abel, Juri Rappsilber, Matthias Mann, and Gideon Dreyfuss 1 2 Howard Hughes Medical Institute, Department of Biochemistry & Biophysics, and Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6148, USA; Laboratoire de Ge´ne´ tique et Physiologie du De´ veloppement, CNRS—Universite´ de la Mediterrane´ e, Marseille, Cedex 09, France; Protein Interaction Laboratory, University of Southern Denmark, DK-5230 Odense M, Denmark Gemin3 is a DEAD-box RNA helicase that binds to the Survival of Motor Neurons (SMN) protein and is a component of the SMN complex, which also comprises SMN, Gemin2, Gemin4, Gemin5, and Gemin6. Reduction in SMN protein results in Spinal muscular atrophy (SMA), a common neurodegenerative disease. The SMN complex has critical functions in the assembly/restructuring of diverse ribonucleoprotein (RNP) complexes. Here we report that Gemin3 and Gemin4 are also in a separate complex that contains eIF2C2, a member of the Argonaute protein family. This novel complex is a large ∼15S RNP http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes & Development Unpaywall

miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs

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Unpaywall
ISSN
0890-9369
DOI
10.1101/gad.974702
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Abstract

Downloaded from genesdev.cshlp.org on November 4, 2021 - Published by Cold Spring Harbor Laboratory Press miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs 1,2 1 1 1 3 Zissimos Mourelatos, Jose´ e Dostie, Sergey Paushkin, Anup Sharma, Bernard Charroux, 1 4 4 1,5 Linda Abel, Juri Rappsilber, Matthias Mann, and Gideon Dreyfuss 1 2 Howard Hughes Medical Institute, Department of Biochemistry & Biophysics, and Department of Pathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-6148, USA; Laboratoire de Ge´ne´ tique et Physiologie du De´ veloppement, CNRS—Universite´ de la Mediterrane´ e, Marseille, Cedex 09, France; Protein Interaction Laboratory, University of Southern Denmark, DK-5230 Odense M, Denmark Gemin3 is a DEAD-box RNA helicase that binds to the Survival of Motor Neurons (SMN) protein and is a component of the SMN complex, which also comprises SMN, Gemin2, Gemin4, Gemin5, and Gemin6. Reduction in SMN protein results in Spinal muscular atrophy (SMA), a common neurodegenerative disease. The SMN complex has critical functions in the assembly/restructuring of diverse ribonucleoprotein (RNP) complexes. Here we report that Gemin3 and Gemin4 are also in a separate complex that contains eIF2C2, a member of the Argonaute protein family. This novel complex is a large ∼15S RNP

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Genes & Development – Unpaywall

Published: Mar 15, 2002

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