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- Publisher
- Wiley
- Copyright
- Copyright © 2006 Journal of Heterocyclic Chemistry
- ISSN
- 0022-152X
- eISSN
- 1943-5193
- DOI
- 10.1002/jhet.5570430208
- Publisher site
- See Article on Publisher Site
Abstract
The reaction of 6‐aminopyrimidin‐4‐ones 1 with benzaldehydes 2 and β‐aminocrotononitrile 3 or benzoylacetonitrile 4 under microwave irradiation in dry media yields the 6‐cyano‐5,8‐dihydropyrido(2,3‐d)‐pyrimidinones 5a‐t. The structure of the synthesized compounds was determined on the basis of nmr measurements, especially by 1H,1H−, 1H,13C COSY, DEPT and NOESY experiments. In contrast with other pyrido‐(2,3‐d)pyrimidine derivatives, these compounds did not show any antifungal in vitro activity up to 250 μg/mL.
Journal
Journal of Heterocyclic Chemistry – Wiley
Published: Mar 1, 2006