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Reference Values of Urinary 3,5,6-Trichloro-2-Pyridinol in the Italian Population—Validation of Analytical Method and Preliminary Results (Multicentric Study)

Reference Values of Urinary 3,5,6-Trichloro-2-Pyridinol in the Italian Population—Validation of... Abstract The interlaboratory validation of analytical procedures for the assay of urinary 3,5,6-trichloro-2-pyridinol (TCP) in the general Italian population is reported. The determinations were performed by high-resolution gas chromatography (HRGS) with electron capture detection and HRGS with mass spectrometry (MS) in 2 laboratories. The urine samples were from 42 participants from 3 regions of Italy. The results were evaluated by interlaboratory quality control. Urinary TCP concentrations were above the detection limit (1.2 (μg/L) in 88% of the population, with a mean detectable concentration [GM (GSD)] of 2.8 (1.9) (μg/g creatinine (creat). (GM, geometric mean; GSD, geometric standard deviation.) The Mann-Whitney U test showed that wine consumption was a statistically significant variable (p < 0.05) for urinary concentrations of TCP. Analysis of variance of the logarithm of urinary TCP versus wine consumption and diet showed a statistically significant fit. The model used explained 30% of the total variance: wine consumption and diet accounted for 37 and 17% respectively of the explained variance. This content is only available as a PDF. © Journal of AOAC International This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) © Journal of AOAC International http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of AOAC INTERNATIONAL Oxford University Press

Reference Values of Urinary 3,5,6-Trichloro-2-Pyridinol in the Italian Population—Validation of Analytical Method and Preliminary Results (Multicentric Study)

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Publisher
Oxford University Press
Copyright
Copyright © 2022 AOAC INTERNATIONAL
ISSN
1060-3271
eISSN
1944-7922
DOI
10.1093/jaoac/82.2.305
Publisher site
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Abstract

Abstract The interlaboratory validation of analytical procedures for the assay of urinary 3,5,6-trichloro-2-pyridinol (TCP) in the general Italian population is reported. The determinations were performed by high-resolution gas chromatography (HRGS) with electron capture detection and HRGS with mass spectrometry (MS) in 2 laboratories. The urine samples were from 42 participants from 3 regions of Italy. The results were evaluated by interlaboratory quality control. Urinary TCP concentrations were above the detection limit (1.2 (μg/L) in 88% of the population, with a mean detectable concentration [GM (GSD)] of 2.8 (1.9) (μg/g creatinine (creat). (GM, geometric mean; GSD, geometric standard deviation.) The Mann-Whitney U test showed that wine consumption was a statistically significant variable (p < 0.05) for urinary concentrations of TCP. Analysis of variance of the logarithm of urinary TCP versus wine consumption and diet showed a statistically significant fit. The model used explained 30% of the total variance: wine consumption and diet accounted for 37 and 17% respectively of the explained variance. This content is only available as a PDF. © Journal of AOAC International This article is published and distributed under the terms of the Oxford University Press, Standard Journals Publication Model (https://academic.oup.com/journals/pages/open_access/funder_policies/chorus/standard_publication_model) © Journal of AOAC International

Journal

Journal of AOAC INTERNATIONAL – Oxford University Press

Published: Mar 1, 1999

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