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Cerebral Blood Flow in Dementia

Cerebral Blood Flow in Dementia Abstract • Twenty-four patients of comparable age, blood pressure, and degree of dementia were classified by an "Ischemic Score" based on clinical features into "multi-infarct" and "primary degenerative" dementia. Regional cerebral blood flow (CBF) was measured by the intracarotid xenon 133 method. Both groups showed a decreased proportion of rapidly clearing brain tissue (largely gray matter). Cerebral blood flow per 100 gm brain per minute was normal in the primary degenerative group but low in the multi-infarct group. This suggests the blood flow is adequate for metabolic needs of the brain in patients with primary degenerative dementia but inadequate for those with multi-infarct dementia. There was no correlation between degree of dementia and CBF in the primary degenerative group but an inverse relationship existed in the multi-infarct group. Reactivity of blood vessels to reduction of arterial carbon dioxide pressure was normal in both groups. References 1. Kay DWK, Beamish P, Roth M: Old age disorders in Newcastle-upon-Tyne . Br J Psychiatry 110:146-158, 1964.Crossref 2. Freyham FA, Woodford RB, Kety SS: Cerebral blood flow and metabolism in psychosis of senility . J Nerv Ment Dis 113:445-456, 1951. 3. Fazekas JF, Bessman AN, Cotsonas NJ, et al: Cerebral hemodynamics in cerebral arteriosclerosis . J Gerontol 8:137-143, 1953.Crossref 4. Lassen NA, Munck O, Tottery ER: Mental function and cerebral oxygen consumption in organic dementia . Arch Neurol Psychiatry 77:126-133, 1957.Crossref 5. Simard D, Olesen J, Paulson O, et al: Regional cerebral blood flow and its regulation in dementia . Brain 94:273-288, 1971.Crossref 6. Gustafson L, Hagberg B, Ingvar DH: Psychiatric symptoms and psychological test results related to regional cerebral blood flow in dementia with early onset , in Meyer JS, et al (eds): Research on Cerebral Circulation . Springfield, Ill, Charles C Thomas Publisher, 1972, pp 291-300. 7. Rothschild D: Neuropathologic changes with arteriosclerotic psychosis and their psychiatric significance . Arch Neurol Psychiatry 48:417-436, 1942.Crossref 8. Corsellis JAN: Mental Illness and the Ageing Brain . London, Oxford University Press, 1962. 9. Newton RD: The identity of Alzheimer's disease and senile dementia and their relationship to senility . J Ment Sci 94:225-249, 1948. 10. Tomlinson BE, Blessed G, Roth M: Observations on the brains of nondemented old people . J Neurol Sci 7:331-356, 1968.Crossref 11. Tomlinson BE, Blessed G, Roth M: Observations on the brains of demented old people . J Neurol Sci 11:205-242, 1970.Crossref 12. Blessed G, Slater E, Roth M: The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects . Br J Psychiatry 114:797-811, 1968.Crossref 13. Mayer-Gross W, Slater E, Roth M: Clinical Psychiatry , ed 3. London, Bailliere, Tindall & Carssell, 1969. 14. Wilkinson IMS, Browne DRG: The influence of anesthesia and of arterial hypocapnia on regional blood flow in the normal human cerebral hemisphere . Br J Anaesth 42:472-482, 1970.Crossref 15. Wilkinson IMS, Bull JWD, Du Boulay GH, et al: Regional blood flow in the normal cerebral hemisphere . J Neurol Neurosurg Psychiatry 32:367-378, 1969.Crossref 16. Iliff L, Zilkha E, Bull JWD, et al: Effect of changes in cerebral blood flow on proportion of high and low flow tissue in the brain . J Neurol Neurosurg Psychiatry 37:631-635, 1974.Crossref 17. Lassen NA, Feinberg I, Lane MH: Bilateral studies of cerebral oxygen uptake in young and aged normal subjects and in patients with organic dementia . J Clin Invest 39:491-500, 1960.Crossref 18. Kety SS: Human cerebral blood flow and oxygen consumption as related to ageing . Assoc Res Nerve Dis Proc 35:31-45, 1956. 19. Sokoloff L: Cerebral hemodynamics in cerebral arteriosclerosis . J Gerontol 8:137-143, 1953.Crossref 20. Ingvar DH, Obist W, Chirian E, et al: General and regional abnormalities of cerebral blood flow in senile and "presenile" dementia . Scand J Clin Lab Invest , (suppl 102) , pp X11B, 1968. 21. Ingvar DH, Gustafson L: Regional cerebral blood flow in organic dementia with early onset . Acta Neurol Scand 43( (suppl 46) ):42-73, 1970. 22. O'Brien MD, Mallett BL: Cerebral cortex perfusion rates in dementia . J Neurol Neurosurg Psychiatry 33:497-500, 1970.Crossref http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Archives of Neurology American Medical Association

Cerebral Blood Flow in Dementia

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References (24)

Publisher
American Medical Association
Copyright
Copyright © 1975 American Medical Association. All Rights Reserved.
ISSN
0003-9942
eISSN
1538-3687
DOI
10.1001/archneur.1975.00490510088009
Publisher site
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Abstract

Abstract • Twenty-four patients of comparable age, blood pressure, and degree of dementia were classified by an "Ischemic Score" based on clinical features into "multi-infarct" and "primary degenerative" dementia. Regional cerebral blood flow (CBF) was measured by the intracarotid xenon 133 method. Both groups showed a decreased proportion of rapidly clearing brain tissue (largely gray matter). Cerebral blood flow per 100 gm brain per minute was normal in the primary degenerative group but low in the multi-infarct group. This suggests the blood flow is adequate for metabolic needs of the brain in patients with primary degenerative dementia but inadequate for those with multi-infarct dementia. There was no correlation between degree of dementia and CBF in the primary degenerative group but an inverse relationship existed in the multi-infarct group. Reactivity of blood vessels to reduction of arterial carbon dioxide pressure was normal in both groups. References 1. Kay DWK, Beamish P, Roth M: Old age disorders in Newcastle-upon-Tyne . Br J Psychiatry 110:146-158, 1964.Crossref 2. Freyham FA, Woodford RB, Kety SS: Cerebral blood flow and metabolism in psychosis of senility . J Nerv Ment Dis 113:445-456, 1951. 3. Fazekas JF, Bessman AN, Cotsonas NJ, et al: Cerebral hemodynamics in cerebral arteriosclerosis . J Gerontol 8:137-143, 1953.Crossref 4. Lassen NA, Munck O, Tottery ER: Mental function and cerebral oxygen consumption in organic dementia . Arch Neurol Psychiatry 77:126-133, 1957.Crossref 5. Simard D, Olesen J, Paulson O, et al: Regional cerebral blood flow and its regulation in dementia . Brain 94:273-288, 1971.Crossref 6. Gustafson L, Hagberg B, Ingvar DH: Psychiatric symptoms and psychological test results related to regional cerebral blood flow in dementia with early onset , in Meyer JS, et al (eds): Research on Cerebral Circulation . Springfield, Ill, Charles C Thomas Publisher, 1972, pp 291-300. 7. Rothschild D: Neuropathologic changes with arteriosclerotic psychosis and their psychiatric significance . Arch Neurol Psychiatry 48:417-436, 1942.Crossref 8. Corsellis JAN: Mental Illness and the Ageing Brain . London, Oxford University Press, 1962. 9. Newton RD: The identity of Alzheimer's disease and senile dementia and their relationship to senility . J Ment Sci 94:225-249, 1948. 10. Tomlinson BE, Blessed G, Roth M: Observations on the brains of nondemented old people . J Neurol Sci 7:331-356, 1968.Crossref 11. Tomlinson BE, Blessed G, Roth M: Observations on the brains of demented old people . J Neurol Sci 11:205-242, 1970.Crossref 12. Blessed G, Slater E, Roth M: The association between quantitative measures of dementia and of senile change in the cerebral grey matter of elderly subjects . Br J Psychiatry 114:797-811, 1968.Crossref 13. Mayer-Gross W, Slater E, Roth M: Clinical Psychiatry , ed 3. London, Bailliere, Tindall & Carssell, 1969. 14. Wilkinson IMS, Browne DRG: The influence of anesthesia and of arterial hypocapnia on regional blood flow in the normal human cerebral hemisphere . Br J Anaesth 42:472-482, 1970.Crossref 15. Wilkinson IMS, Bull JWD, Du Boulay GH, et al: Regional blood flow in the normal cerebral hemisphere . J Neurol Neurosurg Psychiatry 32:367-378, 1969.Crossref 16. Iliff L, Zilkha E, Bull JWD, et al: Effect of changes in cerebral blood flow on proportion of high and low flow tissue in the brain . J Neurol Neurosurg Psychiatry 37:631-635, 1974.Crossref 17. Lassen NA, Feinberg I, Lane MH: Bilateral studies of cerebral oxygen uptake in young and aged normal subjects and in patients with organic dementia . J Clin Invest 39:491-500, 1960.Crossref 18. Kety SS: Human cerebral blood flow and oxygen consumption as related to ageing . Assoc Res Nerve Dis Proc 35:31-45, 1956. 19. Sokoloff L: Cerebral hemodynamics in cerebral arteriosclerosis . J Gerontol 8:137-143, 1953.Crossref 20. Ingvar DH, Obist W, Chirian E, et al: General and regional abnormalities of cerebral blood flow in senile and "presenile" dementia . Scand J Clin Lab Invest , (suppl 102) , pp X11B, 1968. 21. Ingvar DH, Gustafson L: Regional cerebral blood flow in organic dementia with early onset . Acta Neurol Scand 43( (suppl 46) ):42-73, 1970. 22. O'Brien MD, Mallett BL: Cerebral cortex perfusion rates in dementia . J Neurol Neurosurg Psychiatry 33:497-500, 1970.Crossref

Journal

Archives of Neurology – American Medical Association

Published: Sep 1, 1975

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