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References (18)
-
M. Calos (1978)
DNA sequence for a low-level promoter of the lac repressor gene and an ‘up’ promoter mutationNature, 274
-
C. Coulondre, Jeffrey Miller (1977)
Genetic studies of the lac repressor. IV. Mutagenic specificity in the lacI gene of Escherichia coli.Journal of molecular biology, 117 3
-
Jeffrey Miller, D. Ganem, P. Lu, A. Schmitz (1977)
Genetic studies of the lac repressor. I. Correlation of mutational sites with specific amino acid residues: construction of a colinear gene-protein map.Journal of molecular biology, 109 2
-
S. Lederberg (1966)
5-Methylcytosine in the host-modified DNA of Escherichia coli and phage lambda.Journal of molecular biology, 17 1
-
J. Drake, R. Baltz (1976)
The biochemistry of mutagenesis.Annual review of biochemistry, 45
-
H. Boyer, L. Chow, A. Dugaiczyk, J. Hedgpeth, H. Goodman (1973)
DNA substrate site for the EcoRII restriction endonuclease and modification methylase.Nature: New biology, 244 132
-
G. Fasman (1976)
Handbook of Biochemistry -
R. Baltz, P. Bingham, J. Drake (1976)
Heat mutagenesis in bacteriophage T4: the transition pathway.Proceedings of the National Academy of Sciences of the United States of America, 73 4
-
M. Osborn, S. Person, S. Phillips, F. Funk (1967)
A determination of mutagen specificity in bacteria using nonsense mutants of bacteriophage T4.Journal of molecular biology, 26 3
-
R. Shapiro, R. Klein (1966)
The deamination of cytidine and cytosine by acidic buffer solutions. Mutagenic implications.Biochemistry, 5 7
-
D. Steege (1977)
5'-Terminal nucleotide sequence of Escherichia coli lactose repressor mRNA: features of translational initiation and reinitiation sites.Proceedings of the National Academy of Sciences of the United States of America, 74 10
-
Jeffrey Miller, C. Coulondre, P. Farabaugh (1978)
Correlation of nonsense sites in the lacI gene with specific codons in the nucleotide sequenceNature, 274
-
C. Coulondre, Jeffrey Miller (1977)
Genetic studies of the lac repressor. III. Additional correlation of mutational sites with specific amino acid residues.Journal of molecular biology, 117 3
-
P. Farabaugh (1978)
Sequence of the lacI geneNature, 274
-
T. Lindahl, S. Ljungquist, W. Siegert, B. Nyberg, B. Sperens (1977)
DNA N-glycosidases: properties of uracil-DNA glycosidase from Escherichia coli.The Journal of biological chemistry, 252 10
-
C. Yanofsky, J. Ito, V. Horn (1966)
Amino acid replacements and the genetic code.Cold Spring Harbor symposia on quantitative biology, 31
-
G. Butcher, G. Mitchell, S. Cohen (1973)
Mechanism of Host Specificity in Malarial InfectionNature, 244
-
S. Benzer (1961)
ON THE TOPOGRAPHY OF THE GENETIC FINE STRUCTURE.Proceedings of the National Academy of Sciences of the United States of America, 47 3
- Publisher
- Springer Journals
- Copyright
- Copyright © 1978 by Nature Publishing Group
- Subject
- Science, Humanities and Social Sciences, multidisciplinary; Science, Humanities and Social Sciences, multidisciplinary; Science, multidisciplinary
- ISSN
- 0028-0836
- eISSN
- 1476-4687
- DOI
- 10.1038/274775a0
- Publisher site
- See Article on Publisher Site
Abstract
In the lacI gene of Escherichia coli spontaneous base substitution hotspots occur at 5-methylcytosine residues. The hotspots disappear when the respective cytosines are not methylated. We suggest that the hotspots may result from the spontaneous deamination of 5-methylcytosine to thymine, which is not excised by the enzyme DNA-uracil glycosidase.
Journal
Nature – Springer Journals
Published: Aug 24, 1978