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Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain

Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive... Downloaded from genesdev.cshlp.org on October 17, 2021 - Published by Cold Spring Harbor Laboratory Press Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain 1 1 1 2 3 4 Yuan Zhu, Mario I. Romero, Pritam Ghosh, Zhengyi Ye, Patrick Charnay, Elizabeth J. Rushing, 2 1,5 Jamey D. Marth, and Luis F. Parada Center for Developmental Biology and Kent Waldrep Foundation Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9133, USA; Howard Hughes Medical Institute, University of California San Diego, La Jolla, California 92093, USA; Ecole Normale Superieure, Paris, France; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9133, USA Neurofibromatosis type 1 (NF1) is a prevalent genetic disorder that affects growth properties of neural-crest-derived cell populations. In addition, approximately one-half of NF1 patients exhibit learning disabilities. To characterize NF1 function both in vitro and in vivo, we circumvent the embryonic lethality of NF1 null mouse embryos by generating a conditional mutation in the NF1 gene using Cre/loxP technology. Introduction of a Synapsin I promoter driven Cre transgenic mouse strain into the conditional NF1 background has ablated NF1 http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Genes & Development Unpaywall

Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain

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Unpaywall
ISSN
0890-9369
DOI
10.1101/gad.862101
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Abstract

Downloaded from genesdev.cshlp.org on October 17, 2021 - Published by Cold Spring Harbor Laboratory Press Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain 1 1 1 2 3 4 Yuan Zhu, Mario I. Romero, Pritam Ghosh, Zhengyi Ye, Patrick Charnay, Elizabeth J. Rushing, 2 1,5 Jamey D. Marth, and Luis F. Parada Center for Developmental Biology and Kent Waldrep Foundation Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9133, USA; Howard Hughes Medical Institute, University of California San Diego, La Jolla, California 92093, USA; Ecole Normale Superieure, Paris, France; Department of Pathology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9133, USA Neurofibromatosis type 1 (NF1) is a prevalent genetic disorder that affects growth properties of neural-crest-derived cell populations. In addition, approximately one-half of NF1 patients exhibit learning disabilities. To characterize NF1 function both in vitro and in vivo, we circumvent the embryonic lethality of NF1 null mouse embryos by generating a conditional mutation in the NF1 gene using Cre/loxP technology. Introduction of a Synapsin I promoter driven Cre transgenic mouse strain into the conditional NF1 background has ablated NF1

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Genes & Development – Unpaywall

Published: Apr 1, 2001

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