Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

The Role of Endothelial Dysfunction in the Pathophysiology and Cerebrovascular Effects of Migraine: A Narrative Review

The Role of Endothelial Dysfunction in the Pathophysiology and Cerebrovascular Effects of... Background and PurposeMigraine is a complex neurovascular disorder whose triggers are not entirely understood. Endothelial dysfunction might play a role in migraine, and there have been numerous reports on endothelium dysfunction and migraine pathophysiology, but their reciprocal cause–effect relationship remains unclear. This review reports the current evidence on endothelium dysfunction, its link with migraine, and its possible consequences for cerebral hemodynamics.MethodsWe performed a systematic literature search of PubMed up to March 2020. We included 115 articles in a narrative review.ResultsSeveral studies have demonstrated that endothelium dysfunction may play an important role in migraine. Despite the lack of specific biomarkers, there is evidence of oxidative stress and inflammation—two of the primary causes of endothelial damage—in migraine. The main consequences of endothelial dysfunction are increased vascular tone, thrombosis, inflammation, and increased vascular permeability. As a consequence of oxidative stress, the activity of endothelin-1 is not counterbalanced by nitric oxide (NO), whose levels decrease to lead to vasoconstriction and a possible contribution to cortical spreading depression. NO is involved in pain perception via the cyclic guanosine monophosphate (cGMP) pathway and the induction of calcitonin gene-related peptide. Oxidative stress may induce a hypercoagulable state that mainly affects platelet function through different mechanisms. Endothelial dysfunction seems to be particularly pronounced in migraine with aura (MA). Endothelial dysfunction in migraine particularly involves intracranial vessels, since flow-mediated dilation cannot detect overt peripheral vascular dysfunction.ConclusionsEndothelial dysfunction is a vascular risk marker. How it impacts migraine, and particularly MA, needs to be understood better by defining its possible role in increasing the stroke risk in migraine patients. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Clinical Neurology (Seoul, Korea) Pubmed Central

The Role of Endothelial Dysfunction in the Pathophysiology and Cerebrovascular Effects of Migraine: A Narrative Review

Paolucci, Matteo; Altamura, Claudia; Vernieri, Fabrizio
Journal of Clinical Neurology (Seoul, Korea) , Volume 17 (2) – Mar 18, 2021
Download PDF
12 pages

Loading next page...
 
/lp/pubmed-central/the-role-of-endothelial-dysfunction-in-the-pathophysiology-and-lnKxwcTUIa

References

References for this paper are not available at this time. We will be adding them shortly, thank you for your patience.

Publisher
Pubmed Central
Copyright
Copyright © 2021 Korean Neurological Association
ISSN
1738-6586
eISSN
2005-5013
DOI
10.3988/jcn.2021.17.2.164
Publisher site
See Article on Publisher Site

Abstract

Background and PurposeMigraine is a complex neurovascular disorder whose triggers are not entirely understood. Endothelial dysfunction might play a role in migraine, and there have been numerous reports on endothelium dysfunction and migraine pathophysiology, but their reciprocal cause–effect relationship remains unclear. This review reports the current evidence on endothelium dysfunction, its link with migraine, and its possible consequences for cerebral hemodynamics.MethodsWe performed a systematic literature search of PubMed up to March 2020. We included 115 articles in a narrative review.ResultsSeveral studies have demonstrated that endothelium dysfunction may play an important role in migraine. Despite the lack of specific biomarkers, there is evidence of oxidative stress and inflammation—two of the primary causes of endothelial damage—in migraine. The main consequences of endothelial dysfunction are increased vascular tone, thrombosis, inflammation, and increased vascular permeability. As a consequence of oxidative stress, the activity of endothelin-1 is not counterbalanced by nitric oxide (NO), whose levels decrease to lead to vasoconstriction and a possible contribution to cortical spreading depression. NO is involved in pain perception via the cyclic guanosine monophosphate (cGMP) pathway and the induction of calcitonin gene-related peptide. Oxidative stress may induce a hypercoagulable state that mainly affects platelet function through different mechanisms. Endothelial dysfunction seems to be particularly pronounced in migraine with aura (MA). Endothelial dysfunction in migraine particularly involves intracranial vessels, since flow-mediated dilation cannot detect overt peripheral vascular dysfunction.ConclusionsEndothelial dysfunction is a vascular risk marker. How it impacts migraine, and particularly MA, needs to be understood better by defining its possible role in increasing the stroke risk in migraine patients.

Journal

Journal of Clinical Neurology (Seoul, Korea) – Pubmed Central

Published: Mar 18, 2021

References

  • Migraine pathophysiology: lessons from mouse models and human genetics
  • Meta-analysis of 375,000 individuals identifies 38 susceptibility loci for migraine
  • Endothelial dysfunction, vascular disease and stroke: the ARTICO study
  • Does the interdependence between oxidative stress and inflammation explain the antioxidant paradox?
  • Paraoxonase 1 gene polymorphisms, paraoxonase/arylesterase activities and oxidized low-density lipoprotein levels in patients with migraine
  • Oxidative stress in migraine with and without aura
  • The migraine attack as a homeostatic, neuroprotective response to brain oxidative stress: preliminary evidence for a theory
  • Investigation of TNFA 308G > A and TNFB 252G > A polymorphisms in genetic susceptibility to migraine
  • Systemic and cerebral endothelial dysfunction in chronic migraine. A case-control study with an active comparator
  • Migraine and subclinical atherosclerosis: endothelial dysfunction biomarkers and carotid intima-media thickness: a case-control study
  • T-cell subsets and expression of integrins in peripheral blood of patients with migraine
  • Platelet-leukocyte interaction and platelet activation in migraine: a link to ischemic stroke?
  • Platelet dysfunction and stroke in the female migraineur
  • High prevalence of antiendothelial cell antibodies in migraine
  • The relationship between homocysteine and genes of folate-related enzymes in migraine patients
  • The levels of circulating proangiogenic factors in migraineurs
  • Endothelial progenitor cells: a new key for endothelial dysfunction in migraine
  • Circulating endothelial progenitor cells, vascular function, and cardiovascular risk
  • Endothelial dysfunction in patients with rheumatoid arthritis is associated with a reduced number and impaired function of endothelial progenitor cells
  • Decreased number and function of endothelial progenitor cells in patients with migraine
  • Analysis of endothelial precursor cells in chronic migraine: a case-control study
  • Stromal cell-derived factor-1 alpha is decreased in women with migraine with aura
  • Circulating microparticles from patients with myocardial infarction cause endothelial dysfunction
  • Circulating endothelial microparticles in female migraineurs with aura
  • Markers of endothelial function in migraine patients: results from a bi-center prospective study
  • Iron deposition in periaqueductal gray matter as a potential biomarker for chronic migraine
  • Pentraxin 3 (PTX3): a molecular marker of endothelial dysfunction in chronic migraine
  • Urinary albumin excretion as a marker of endothelial dysfunction in migraine sufferers: the HUNT Study, Norway
  • Migraine as a systemic vasculopathy
  • Targeted nitric oxide synthase inhibitors for migraine
  • Nitric oxide in primary headaches
  • Nitric oxide and the cerebral vascular function
  • Activation of meningeal 5-HT2B receptors: an early step in the generation of migraine headache?
  • Calcitonin gene-related peptide mediates nitroglycerin and sodium nitroprusside-induced vasodilation in feline cerebral arterioles
  • CGRP and brain functioning: cautions for migraine treatment
  • Nitric oxide synthase inhibitors can antagonize neurogenic and calcitonin gene-related peptide induced dilation of dural meningeal vessels
  • The interaction between endothelin-1 and nitric oxide in the vasculature: new perspectives
  • The role of endothelin in the pathophysiology of migraine-a systematic review
  • Endothelin in migraine patients
  • Endothelial, haemostatic and haemorheological modifications in migraineurs
  • Vascular risk factors, endothelial function, and carotid thickness in patients with migraine: relationship to atherosclerosis
  • Endothelin 1 in migraine and tension-type headache
  • Role of endothelial cells in antihyperalgesia induced by a triptan and β-blocker
  • Endothelin-1 potently induces Leão's cortical spreading depression in vivo in the rat: a model for an endothelial trigger of migrainous aura?
  • Endothelin-1-induced spreading depression in rats is associated with a microarea of selective neuronal necrosis
  • Intravenous endothelin-1 infusion does not induce aura or headache in migraine patients with aura
  • Calcitonin gene-related peptide triggers migraine-like attacks in patients with migraine with aura
  • Glyceryl trinitrate induces attacks of migraine without aura in sufferers of migraine with aura
  • Induction of migraine-like headache, but not aura, by cilostazol in patients with migraine with aura
  • Enhanced nitric oxide release during cortical spreading depression following infusion of glyceryl trinitrate in the anaesthetized cat
  • SB-220453, a potential novel antimigraine agent, inhibits nitric oxide release following induction of cortical spreading depression in the anaesthetized cat
  • Sumatriptan modifies cortical free radical release during cortical spreading depression: a novel antimigraine action for sumatriptan?
  • Nitric oxide synthase inhibition in migraine
  • Nitric oxide synthase inhibition: a new principle in the treatment of migraine attacks
  • Neurogenic dural protein extravasation induced by meta-chlorophenylpiperazine (mCPP) involves nitric oxide and 5-HT2B receptor activation
  • Headache-type adverse effects of NO donors: vasodilation and beyond
  • Mechanisms mediating nitroglycerin-induced delayed-onset hyperalgesia in the rat
  • Urinary nitric oxide metabolites and lipid peroxidation byproducts in migraine
  • Asymmetric dimethylarginine and nitric oxide levels in migraine during the interictal period
  • Endothelial function in patients with migraine during the interictal period
  • Vascular smooth muscle cell dysfunction in patients with migraine
  • Endothelial function in migraine: a cross-sectional study
  • Migraine attack restores the response of vascular smooth muscle cells to nitric oxide but not to norepinephrine
  • Migraine and biomarkers of endothelial activation in young women
  • Increased asymmetric dimethylarginine and nitric oxide levels in patients with migraine
  • Serum L-arginine and dimethylarginine levels in migraine patients with brain white matter lesions
  • Endothelial function in migraine with aura - a systematic review
  • Altered arterial function in migraine of recent onset
  • Patients with migraine with aura have increased flow mediated dilation
  • Associations between cerebral and systemic endothelial function in migraine patients: a post-hoc study
  • Increased dilator response to nitrate and decreased flow-mediated dilatation in migraineurs
  • Endothelial function in patients with migraine without aura during the interictal period
  • Endothelial dysfunction state in migraine headache and neutrally mediated syncope in children and young adults
  • Endothelial and autonomic functions in patients with migraine
  • Interictal cerebral and systemic endothelial dysfunction in patients with migraine: a case-control study
  • Migraine and endothelial function: the HUNT3 Study
  • Peripheral endothelial function and arterial stiffness in women with migraine with aura: a case-control study
  • The effect of prophylactic migraine treatment on arterial stiffness
  • Peripheral endothelial function and arterial stiffness in patients with chronic migraine: a case-control study
  • Serotonin and the vascular system. Role in health and disease, and implications for therapy
  • Endothelial expression of the 5-hydroxytryptamine1B antimigraine drug receptor in rat and human brain microvessels
  • Contractile 5-HT1B receptors in human cerebral arteries: pharmacological characterization and localization with immunocytochemistry
  • Vascular effects of 5-HT1B/1D-receptor agonists in patients with migraine headaches
  • Putative role of 5-HT2B receptors in migraine pathophysiology
  • The 5-hydroxytryptamine-nitric oxide connection: the key link in the initiation of migraine?
  • The role of purinergic signaling in the etiology of migraine and novel antimigraine treatment
  • Purinergic signaling in the cardiovascular system
  • Cerebral endothelial cells are a major source of adrenomedullin
  • Shear stress-induced endothelial adrenomedullin signaling regulates vascular tone and blood pressure
  • Mechanisms of adrenomedullin-induced dilatation of cerebral arterioles
  • Adrenomedullin: an important participant in neurological diseases
  • Effect of adrenomedullin on the cerebral circulation: relevance to primary headache disorders
  • The differential effects of oestrogens and progestins on vascular tone
  • Ovarian hormones and migraine headache: understanding mechanisms and pathogenesis--part I
  • Functional TCD: regulation of cerebral hemodynamics--cerebral autoregulation, vasomotor reactivity, and neurovascular coupling
  • Outcome of carotid artery occlusion is predicted by cerebrovascular reactivity
  • Increased cerebral vasomotor reactivity in migraine with aura: an autoregulation disorder? A transcranial doppler and near-infrared spectroscopy study
  • Cerebrovascular CO2 reactivity in migraine with aura and without aura. A transcranial Doppler study
  • Basilar and middle cerebral artery reactivity in patients with migraine
  • Paradoxical association between age and cerebrovascular reactivity in migraine: a cross-sectional study
  • Right-to-left shunts and hormonal therapy influence cerebral vasomotor reactivity in patients with migraine with aura
  • Is migraine associated with right-to-left shunt a separate disease? Results of the SAM study
  • Erenumab does not alter cerebral hemodynamics and endothelial function in migraine without aura
  • Cerebrovascular reactivity to L-arginine in the anterior and posterior cerebral circulation in migraine patients
  • Profiling cerebrovascular function in migraine: a systematic review and meta-analysis
  • Confounding of cerebral blood flow velocity by blood pressure during breath holding or hyperventilation in transient ischemic attack or stroke
  • Migraine and vascular disease biomarkers: a population-based case-control study
  • Serum levels of endocan, claudin-5 and cytokines in migraine
  • Increased von Willebrand factor in migraine
  • Increased levels of plasma von Willebrand factor in migraine crisis
  • Altered hemostasis in migraineurs studied with a dynamic flow system
  • Association of von Willebrand factor activity with ACE I/D and MTHFR C677T polymorphisms in migraine
  • A possible role of amyloidogenic blood clotting in the evolving haemodynamics of female migraine-with-aura: results from a pilot study
  • Neurogenic inflammation and migraine: implications for the therapeutics
  • Vascular contributions to migraine: time to revisit?