Get 20M+ Full-Text Papers For Less Than $1.50/day. Start a 7-Day Trial for You or Your Team.

Learn More →

Mesencephalic control of lateral geniculate nucleus in primates. I. Electrophysiology

Mesencephalic control of lateral geniculate nucleus in primates. I. Electrophysiology 221 18 18 2 2 Robert W. Doty Paul D. Wilson John R. Bartlett Jorge Pecci-Saavedra Center for Brain Research University of Rochester Rochester USA Psychology Department University of California 92502 Riverside California General y Embriologia Instituto de Anatomia Paraguay 2155 Buenos Aires Argentina Summary 1. In squirrel monkeys or macaques under barbiturate anesthesia one or a few electrical pulses applied to the mesencephalic reticular formation or pretectal area alters synaptic transmission through the lateral geniculate nucleus, as tested by magnitude of response in optic radiation to stimulation of optic tract. The effect begins within 5–10 msec after the start of the mesencephalic stimulation and is usually biphasic. Initial inhibition lasts for about 30 msec and is then replaced by facilitation which peaks around 70–120 msec and may endure as much as 1 sec. 2. The major site of the effect is upon the lateral geniculate nucleus, and both magno- and parvocellular elements are involved. Only rarely does the mesencephalic stimulation directly alter excitability of striate cortex. 3. In this respect, as well as in the strong facilitation of photically elicited responses, the effects in primates differ significantly from those in cats. 4. Although the inhibition observed in the lateral geniculate nucleus meets criteria commonly believed to signify a presynaptic origin, several paradoxical facts (see Discussion) must be resolved before this interpretation can be secure. 5. It is hypothesized that the observed effects arise primarily from intrusion into a system normally concerned with the acquisition of visual information by ocular saccades. Saccadic gating of transmission through the lateral geniculate nucleus would distinguish self-generated visual signals from similar, extrinsically initiated signals, and would thus constitute the “corollary discharge”. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Experimental Brain Research Springer Journals

Mesencephalic control of lateral geniculate nucleus in primates. I. Electrophysiology

Download PDF
15 pages

Loading next page...
 
/lp/springer-journals/mesencephalic-control-of-lateral-geniculate-nucleus-in-primates-i-lQ742gPU4j

References (48)

Publisher
Springer Journals
Copyright
Copyright © 1973 by Springer-Verlag
Subject
Biomedicine; Neurosciences; Neurology
ISSN
0014-4819
eISSN
1432-1106
DOI
10.1007/BF00234723
Publisher site
See Article on Publisher Site

Abstract

221 18 18 2 2 Robert W. Doty Paul D. Wilson John R. Bartlett Jorge Pecci-Saavedra Center for Brain Research University of Rochester Rochester USA Psychology Department University of California 92502 Riverside California General y Embriologia Instituto de Anatomia Paraguay 2155 Buenos Aires Argentina Summary 1. In squirrel monkeys or macaques under barbiturate anesthesia one or a few electrical pulses applied to the mesencephalic reticular formation or pretectal area alters synaptic transmission through the lateral geniculate nucleus, as tested by magnitude of response in optic radiation to stimulation of optic tract. The effect begins within 5–10 msec after the start of the mesencephalic stimulation and is usually biphasic. Initial inhibition lasts for about 30 msec and is then replaced by facilitation which peaks around 70–120 msec and may endure as much as 1 sec. 2. The major site of the effect is upon the lateral geniculate nucleus, and both magno- and parvocellular elements are involved. Only rarely does the mesencephalic stimulation directly alter excitability of striate cortex. 3. In this respect, as well as in the strong facilitation of photically elicited responses, the effects in primates differ significantly from those in cats. 4. Although the inhibition observed in the lateral geniculate nucleus meets criteria commonly believed to signify a presynaptic origin, several paradoxical facts (see Discussion) must be resolved before this interpretation can be secure. 5. It is hypothesized that the observed effects arise primarily from intrusion into a system normally concerned with the acquisition of visual information by ocular saccades. Saccadic gating of transmission through the lateral geniculate nucleus would distinguish self-generated visual signals from similar, extrinsically initiated signals, and would thus constitute the “corollary discharge”.

Journal

Experimental Brain Research – Springer Journals

Published: Sep 1, 1973

There are no references for this article.