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An application of methods for clustered binary responses to a cardiovascular study with small sample size

An application of methods for clustered binary responses to a cardiovascular study with small... This paper discusses statistical methods for a cardiovascular study in which each of eight animals had a dichotomous outcome observed for each of several treatments. There were five treatments in all shunt, control, two doses of a test drug for potentially causing an unfavorable car- diovascular event and a combination of the test drug and a counteracting agent. Exact conditional methods were used through LogXact a statistical software for exact logistic regression and an alternative framework for performing a large class of nonparametric tests performed by StatXact. The results agreed reasonably with asymptotic methods even though the sample size was small. http://www.deepdyve.com/assets/images/DeepDyve-Logo-lg.png Journal of Biopharmaceutical Statistics Taylor & Francis

An application of methods for clustered binary responses to a cardiovascular study with small sample size

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References (8)

Publisher
Taylor & Francis
Copyright
Copyright Taylor & Francis Group, LLC
ISSN
1520-5711
eISSN
1054-3406
DOI
10.1080/10543409808835224
pmid
9547429
Publisher site
See Article on Publisher Site

Abstract

This paper discusses statistical methods for a cardiovascular study in which each of eight animals had a dichotomous outcome observed for each of several treatments. There were five treatments in all shunt, control, two doses of a test drug for potentially causing an unfavorable car- diovascular event and a combination of the test drug and a counteracting agent. Exact conditional methods were used through LogXact a statistical software for exact logistic regression and an alternative framework for performing a large class of nonparametric tests performed by StatXact. The results agreed reasonably with asymptotic methods even though the sample size was small.

Journal

Journal of Biopharmaceutical StatisticsTaylor & Francis

Published: Jan 1, 1998

Keywords: Exact logistic regression; Conditional logistic regression; Multiperiod study; Odds ratios; Confidence intervals

There are no references for this article.