Access the full text.
Sign up today, get DeepDyve free for 14 days.
F. Weerkamp, J Dongen, F. Staal (2006)
Notch and Wnt signaling in T-lymphocyte development and acute lymphoblastic leukemiaLeukemia, 20
Tracie DeVries-Seimon, A. Ohm, M. Humphries, M. Reyland (2007)
Induction of Apoptosis Is Driven by Nuclear Retention of Protein Kinase Cδ*Journal of Biological Chemistry, 282
R. Marone, Vladimir Cmiljanović, B. Giese, M. Wymann (2008)
Targeting phosphoinositide 3-kinase: moving towards therapy.Biochimica et biophysica acta, 1784 1
P. Tazzari, G. Tabellini, R. Bortul, V. Papa, C. Evangelisti, T. Grafone, Giovanni Martinelli, J. McCubrey, A. Martelli, A. Martelli (2007)
The insulin-like growth factor-I receptor kinase inhibitor NVP-AEW541 induces apoptosis in acute myeloid leukemia cells exhibiting autocrine insulin-like growth factor-I secretionLeukemia, 21
B. Zhivotovsky, S. Orrenius (2005)
Caspase-2 function in response to DNA damage.Biochemical and biophysical research communications, 331 3
Teresa Palomero, M. Sulis, Maria Cortina, P. Real, Kelly Barnes, M. Ciofani, E. Caparrós, J. Buteau, K. Brown, S. Perkins, G. Bhagat, A. Agarwal, G. Basso, M. Castillo, S. Nagase, C. Cordon-Cardo, R. Parsons, J. Zúñiga-Pflücker, M. Dominguez, A. Ferrando (2007)
Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemiaNature Medicine, 13
J. Markovits, Y. Pommier, D. Kerrigan, J. Covey, E. Tilchen, K. Kohn (1987)
Topoisomerase II-mediated DNA breaks and cytotoxicity in relation to cell proliferation and the cell cycle in NIH 3T3 fibroblasts and L1210 leukemia cells.Cancer research, 47 8
Yan Luo, A. Shoemaker, X. Liu, K. Woods, Sheela Thomas, R. Jong, E. Han, Tongmei Li, V. Stoll, Jessica Powlas, Anatol Oleksijew, M. Mitten, Yan Shi, R. Guan, T. Mcgonigal, V. Klinghofer, Eric Johnson, J. Leverson, J. Bouska, M. Mamo, R. Smith, Emily Gramling-Evans, B. Zinker, Amanda Mika, P. Nguyen, T. Oltersdorf, S. Rosenberg, Qun Li, V. Giranda (2005)
Potent and selective inhibitors of Akt kinases slow the progress of tumors in vivoMolecular Cancer Therapeutics, 4
K. Hagino‐Yamagishi, K. Toyoshima (2019)
[Oncogene].Gan to kagaku ryoho. Cancer & chemotherapy, 10 7
S. Uddin, A. Hussain, K. Al-Hussein, L. Platanias, K. Bhatia (2004)
Inhibition of phosphatidylinositol 3'-kinase induces preferentially killing of PTEN-null T leukemias through AKT pathway.Biochemical and biophysical research communications, 320 3
EK-H Han, J. Leverson, T. Mcgonigal, OJ Shah, KW Woods, T. Hunter, VL Giranda, Y. Luo (2007)
Akt inhibitor A-443654 induces rapid Akt Ser-473 phosphorylation independent of mTORC1 inhibitionOncogene, 26
P. D'Arpa, Chris Beardmore, Leroy Liu (1990)
Involvement of nucleic acid synthesis in cell killing mechanisms of topoisomerase poisons.Cancer research, 50 21
C. Lindsley, S. Barnett, M. Layton, M. Bilodeau (2008)
The PI3K/Akt pathway: recent progress in the development of ATP-competitive and allosteric Akt kinase inhibitors.Current cancer drug targets, 8 1
Shirin Kazemi, Z. Mounir, D. Baltzis, Jennifer Raven, Shuo Wang, J. Krishnamoorthy, O. Pluquet, J. Pelletier, A. Koromilas (2007)
A Novel Function of eIF2α Kinases as Inducers of the Phosphoinositide-3 Kinase Signaling PathwayMolecular Biology of the Cell, 18
A. Tinel, J. Tschopp (2004)
The PIDDosome, a Protein Complex Implicated in Activation of Caspase-2 in Response to Genotoxic StressScience, 304
V. Papa, P. Tazzari, F. Chiarini, A. Cappellini, F. Ricci, A. Billi, C. Evangelisti, E. Ottaviani, G. Martinelli, N. Testoni, J. McCubrey, A. Martelli (2008)
Proapoptotic activity and chemosensitizing effect of the novel Akt inhibitor perifosine in acute myelogenous leukemia cellsLeukemia, 22
A. Tafuri, C. Gregorj, M. Petrucci, M. Ricciardi, M. Mancini, G. Cimino, C. Mecucci, A. Tedeschi, G. Fioritoni, F. Ferrara, F. Raimondo, E. Gallo, V. Liso, F. Fabbiano, N. Cascavilla, G. Pizzolo, A. Camera, F. Pane, F. Lanza, D. Cilloni, L. Annino, A. Vitale, M. Vegna, M. Vignetti, R. Foà, F. Mandelli (2002)
MDR1 protein expression is an independent predictor of complete remission in newly diagnosed adult acute lymphoblastic leukemia.Blood, 100 3
A. Vitale, A. Guarini, C. Ariola, M. Mancini, C. Mecucci, A. Cuneo, F. Pane, G. Saglio, G. Cimino, A. Tafuri, G. Meloni, F. Fabbiano, A. Recchia, M. Kropp, M. Krampera, N. Cascavilla, F. Ferrara, A. Romano, P. Mazza, C. Fozza, F. Paoloni, M. Vignetti, R. Foà (2006)
Adult T-cell acute lymphoblastic leukemia: biologic profile at presentation and correlation with response to induction treatment in patients enrolled in the GIMEMA LAL 0496 protocol.Blood, 107 2
Department of Human Anatomical Sciences
E. Okumura, Takeshi Fukuhara, H. Yoshida, Shin-ichiro Hanada, Rie Kozutsumi, M. Mori, K. Tachibana, T. Kishimoto (2002)
Akt inhibits Myt1 in the signalling pathway that leads to meiotic G2/M-phase transitionNature Cell Biology, 4
C. Grabher, H. Boehmer, A. Look (2006)
Notch 1 activation in the molecular pathogenesis of T-cell acute lymphoblastic leukaemiaNature Reviews Cancer, 6
Amanda Martelli, M. Nyåkern, G. Tabellini, R. Bortul, P. Tazzari, C. Evangelisti, L. Cocco (2006)
Phosphoinositide 3-kinase/Akt signaling pathway and its therapeutical implications for human acute myeloid leukemiaLeukemia, 20
M. Seminario, P. Precht, R. Wersto, M. Gorospe, R. Wange (2003)
PTEN expression in PTEN-null leukaemic T cell lines leads to reduced proliferation via slowed cell cycle progressionOncogene, 22
J. Shelton, W. Blalock, Edmond White, L. Steelman, J. McCubrey (2004)
Ability of the Activated PI3K/Akt Oncoproteins to Synergize with MEK1 and Induce Cell Cycle Progression and Abrogate the Cytokine-Dependence of Hematopoietic CellsCell Cycle, 3
P. Tazzari, A. Cappellini, Francesca Ricci, C. Evangelisti, V. Papa, T. Grafone, Giovanni Martinelli, Roberto Conte, L. Cocco, J. McCubrey, Amanda Martelli, Amanda Martelli (2007)
Multidrug resistance-associated protein 1 expression is under the control of the phosphoinositide 3 kinase/Akt signal transduction network in human acute myelogenous leukemia blastsLeukemia, 21
E. Tokunaga, E. Oki, A. Egashira, N. Sadanaga, M. Morita, Y. Kakeji, Y. Maehara (2008)
Deregulation of the Akt pathway in human cancer.Current cancer drug targets, 8 1
S. Frame, P. Cohen (2001)
GSK3 takes centre stage more than 20 years after its discovery.The Biochemical journal, 359 Pt 1
L. Neri, P. Borgatti, P. Tazzari, R. Bortul, A. Cappellini, G. Tabellini, A. Bellacosa, S. Capitani, A. Martelli (2003)
The phosphoinositide 3-kinase/AKT1 pathway involvement in drug and all-trans-retinoic acid resistance of leukemia cells.Molecular cancer research : MCR, 1 3
Q. Fan, Z. Knight, David Goldenberg, Wei Yu, K. Mostov, D. Stokoe, K. Shokat, W. Weiss (2006)
A dual PI3 kinase/mTOR inhibitor reveals emergent efficacy in glioma.Cancer cell, 9 5
J. LoPiccolo, G. Blumenthal, W. Bernstein, P. Dennis (2008)
Targeting the PI3K/Akt/mTOR pathway: effective combinations and clinical considerations.Drug resistance updates : reviews and commentaries in antimicrobial and anticancer chemotherapy, 11 1-2
J. Bain, Lorna Plater, M. Elliott, N. Shpiro, J. Hastie, Hilary, Mclauchlan, Iva Klevernic, Simon Arthur, D. Alessi, P. Cohen (2007)
The selectivity of protein kinase inhibitors: a further update.The Biochemical journal, 408 3
K. Katayama, N. Fujita, T. Tsuruo (2005)
Akt/Protein Kinase B-Dependent Phosphorylation and Inactivation of WEE1Hu Promote Cell Cycle Progression at G2/M TransitionMolecular and Cellular Biology, 25
E. Sale, G. Sale (2007)
Protein kinase B: signalling roles and therapeutic targetingCellular and Molecular Life Sciences, 65
I. Mantovani, A. Cappellini, P. Tazzari, V. Papa, L. Cocco, A. Martelli (2006)
Caspase‐dependent cleavage of 170‐kDa P‐glycoprotein during apoptosis of human T‐lymphoblastoid CEM cellsJournal of Cellular Physiology, 207
W. Blalock, W. Blalock, P. Navolanic, L. Steelman, J. Shelton, P. Moye, John Lee, R. Franklin, A. Mirza, M. McMahon, M. White, J. McCubrey (2003)
Requirement for the PI3K/Akt pathway in MEK1-mediated growth and prevention of apoptosis: identification of an Achilles heel in leukemiaLeukemia, 17
Steven Chan, A. Weng, R. Tibshirani, J. Aster, P. Utz (2007)
Notch signals positively regulate activity of the mTOR pathway in T-cell acute lymphoblastic leukemia.Blood, 110 1
T. Eagar, Q. Tang, M. Wolfe, Yiping He, W. Pear, J. Bluestone (2004)
Notch 1 signaling regulates peripheral T cell activation.Immunity, 20 4
A. Vitale, A. Guarini, S. Chiaretti, R. Foà (2006)
The changing scene of adult acute lymphoblastic leukemiaCurrent Opinion in Oncology, 18
M. Nyåkern, A. Cappellini, I. Mantovani, A. Martelli (2006)
Synergistic induction of apoptosis in human leukemia T cells by the Akt inhibitor perifosine and etoposide through activation of intrinsic and Fas-mediated extrinsic cell death pathwaysMolecular Cancer Therapeutics, 5
Molecular Pharmacology – Unpaywall
Published: Jun 25, 2008
Read and print from thousands of top scholarly journals.
Already have an account? Log in
Bookmark this article. You can see your Bookmarks on your DeepDyve Library.
To save an article, log in first, or sign up for a DeepDyve account if you don’t already have one.
Copy and paste the desired citation format or use the link below to download a file formatted for EndNote
Access the full text.
Sign up today, get DeepDyve free for 14 days.
All DeepDyve websites use cookies to improve your online experience. They were placed on your computer when you launched this website. You can change your cookie settings through your browser.